A5072947784- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Stroke Rehabilitation and Recovery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal pain and rehabilitation
- Spinal Cord Injury Research
- Telemedicine and Telehealth Implementation
- Pain Management and Treatment
- Pain Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Heart Rate Variability and Autonomic Control
- Inflammasome and immune disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Cancer-related cognitive impairment studies
- Traumatic Brain Injury Research
- Botulinum Toxin and Related Neurological Disorders
- Respiratory Support and Mechanisms
- Management of metastatic bone disease
- Transcranial Magnetic Stimulation Studies
- Balance, Gait, and Falls Prevention
Icahn School of Medicine at Mount Sinai
2020-2025
The Mount
2020
Abstract Post-acute infection syndromes may develop after acute viral disease 1 . Infection with SARS-CoV-2 can result in the development of a post-acute syndrome known as long COVID. Individuals COVID frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions 2–4 However, biological processes that are associated persistence these symptoms unclear. Here 275 individuals or without were enrolled cross-sectional study included multidimensional...
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection found white-matter-selective in mice humans. Following mild mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, myelin loss were evident together with...
SARS-CoV-2 infection can result in the development of a constellation persistent sequelae following acute disease called post-acute COVID-19 (PASC) or Long COVID 1-3 . Individuals diagnosed with frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions ; however, basic biological mechanisms responsible for these debilitating symptoms are unclear. Here, 215 individuals were included an exploratory, cross-sectional study to perform...
This report describes persistent symptoms associated with post-acute COVID-19 syndrome (PACS) and the impact of these on physical function, cognitive health-related quality life, participation.This study used a cross-sectional observational design. Patients attending Mount Sinai's clinic completed surveys containing patient-reported outcomes.A total 156 patients survey, at median (range) time 351 days (82-457 days) after infection. All were prevaccination. The most common reported fatigue (n...
Determine the characteristics of postintensive care syndrome in cognitive, physical, and psychiatric domains coronavirus disease 2019 ICU survivors.Single-center descriptive cohort study from April 21, to July 7, 2020.Critical recovery clinic at The Mount Sinai Hospital New York City.Adults who had critical illness due requiring an stay 7 days or more agreed a telehealth follow-up 1-month post hospital discharge.None.Patient-reported outcome measures assessing physical were collected...
Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed information processing and memory. This long-COVID cognitive syndrome shares many features with the cancer therapy-related (CRCI). Neuroinflammation, particularly microglial reactivity consequent dysregulation hippocampal neurogenesis oligodendrocyte lineage cells, is central to CRCI. We hypothesized...
Summary Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present LC after acute SARS-CoV-2 infection 1–7 . However, whether immunological traits underlying differ between sexes, such explain differential symptomology is currently unknown. Here, we performed sex-based multi-dimensional immune-endocrine profiling 165 individuals 8 without an exploratory, cross-sectional study identify key...
Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified AAB targets LC patients that correlated their symptoms. Elevated AABs to proteins nervous system were neurocognitive neurological Purified Immunoglobulin G (IgG) samples from these reacted pons tissue cross-reactive mouse sciatic nerves,...
Background: Coronavirus disease 2019 (COVID-19) poses a global public health emergency, overwhelming systems worldwide and forcing rapid adoption of telemedicine strategies.
People with disabilities are at higher risk of severe illness from COVID-19. They may also suffer lack accessible emergency preparedness plans, communication and healthcare. Protective measures for people should be endorsed prioritized a community level to adjust social distancing. Repositories local resources outreach in this time crucial. Telemedicine offers an innovative safe way health providers care access many critical services without placing themselves or their caregivers increased...
Abstract Introduction One of the noted features COVID-19 is spectrum expressivity in symptoms among those with disease, ranging from no or mild that may last a small number days, to severe and/or longer lasting symptoms. It emerging many patients have long symptoms, several months after initial infection COVID-19. The aim this research was characterize post-acute syndrome (PACS). Methods This retrospective cross-sectional observational study. Participants were recovering infection, enrolled...
Abstract Objective The Neuropathic Pain Symptom Inventory (NPSI) is commonly used assessment in (NP) trials, yet a Minimal Clinically Important Difference (MCID) has not been established. A MCID would enhance the interpretability of NPSI scores, guiding clinicians and researchers assessing clinically important improvements NP symptoms. aim this study was to calculate an from available scientific research that NPSI. Methods We conducted systematic review meta-analysis trials reporting Three...
COVID-19 vaccines have prevented millions of deaths. Yet, a small fraction the population reports chronic debilitating condition after vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in Yale LISTEN study. Compared controls, exhibited differences immune profiles, including reduced circulating...
Introduction Long COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken rehabilitation for autonomic dysfunction to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing (breathing slowly at a defined rate breaths per minute) requires less exertion can potentially improve function. The objective this work was report on the impact resonant program self-reported symptoms wellbeing in people COVID....
Purpose: Long COVID (LC) is an ongoing public health crisis due to the persistent and debilitating symptoms that many individuals develop after surviving acute SARS-CoV-2 infection. Neurocognitive impairments associated with LC are prevalent difficult treat. This study describes clinical characteristics outcomes from a cohort of patients examines how cognitive dysfunction related various other domains such as function, neuropsychiatric issues, quality life. Methods: Retrospective...
Introduction: People with Spinal Cord Injury (SCI) are at risk of feeling socially disconnected. Competitive esports present an opportunity for people SCI to remotely engage in a community. The aim this study is discuss barriers participation SCI, adaptive solutions these problems, and analyze self-reported changes social connection. Materials Methods: We presented descriptive data collected the process quality improvement initiative Mount Sinai Hospital. In 2019, seven individuals cervical...
Introduction: Telehealth was frequently used in the provision of care and remote patient monitoring (RPM) during COVID-19 pandemic. The Precision Recovery Program (PRP) remotely monitored supported patients with their home environment. Materials Methods: This a single-center retrospective cohort study reviewing data acquired from PRP clinical initiative. Results: Of 679 enrolled PRP, 156 were screened by clinician following deterioration symptoms vital signs on total 240 occasions, included...
Abstract Introduction: Neuropathic pain (NP) poses significant challenges for individuals with spinal cord injury (SCI), often inadequately managed by current interventions. Immersive virtual reality (IVR) has emerged as a promising approach modulation, yet robust evidence is lacking. Objectives: This pilot study investigated the analgesic effects of different IVR environments (scenic, somatic) compared control environment, and explored psychomotor properties influencing attenuation....
Abstract N/A - Letter to the Editor
Emerging literature suggests that virtual reality (VR) may be a viable therapy for neuropathic pain (NP). This pilot study aimed to investigate the immediate effect of VR in reducing NP people with spinal cord injury (SCI). Eight individuals chronic after SCI were recruited and underwent consecutive exposure scenery somatic environments (VE). The numeric rating scale (NRS) was used assess before each VE. Immersive Tendencies Questionnaire (ITQ) Presence (UQO-PQ) interaction between reported...
Abstract Post-acute COVID-19 syndrome (PACS) is a collection of persistent and debilitating symptoms lasting weeks to months after acute infection, with fatigue most commonly reported. There controversy surrounding the role exercise programs for this condition, due concerns over potential worsen fatigue. We developed novel physical therapy program known as Autonomic Conditioning Therapy (ACT) PACS, report on preliminary patient-reported outcome (PRO) data from individuals who completed ACT...
Background: Resting tremor is a cardinal symptom of Parkinson’s disease (PD) that contributes to the physical, emotional, and economic burden disease. Objective: The goal this study was investigate safety, tolerability, preliminary effectiveness novel wearable vibrotactile stimulation device on resting in individuals with PD. Methods: Using randomized cross-over design, subjects received two different paradigms (high amplitude patterned low continuous) separate laboratory visits. On each...