A5065059780- Stroke Rehabilitation and Recovery
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Cerebral Palsy and Movement Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Traumatic Brain Injury Research
- Vagus Nerve Stimulation Research
- Hemodynamic Monitoring and Therapy
- Cancer-related cognitive impairment studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Takotsubo Cardiomyopathy and Associated Phenomena
- Healthcare Technology and Patient Monitoring
- Family and Patient Care in Intensive Care Units
- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Balance, Gait, and Falls Prevention
- Advanced Neuroimaging Techniques and Applications
- Thermal Regulation in Medicine
- Prosthetics and Rehabilitation Robotics
- Pain Management and Treatment
Icahn School of Medicine at Mount Sinai
2021-2025
Mount Sinai Health System
2024
Anna Needs Neuroblastoma Answers
2024
Abstract Post-acute infection syndromes may develop after acute viral disease 1 . Infection with SARS-CoV-2 can result in the development of a post-acute syndrome known as long COVID. Individuals COVID frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions 2–4 However, biological processes that are associated persistence these symptoms unclear. Here 275 individuals or without were enrolled cross-sectional study included multidimensional...
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection found white-matter-selective in mice humans. Following mild mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, myelin loss were evident together with...
SARS-CoV-2 infection can result in the development of a constellation persistent sequelae following acute disease called post-acute COVID-19 (PASC) or Long COVID 1-3 . Individuals diagnosed with frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions ; however, basic biological mechanisms responsible for these debilitating symptoms are unclear. Here, 215 individuals were included an exploratory, cross-sectional study to perform...
This report describes persistent symptoms associated with post-acute COVID-19 syndrome (PACS) and the impact of these on physical function, cognitive health-related quality life, participation.This study used a cross-sectional observational design. Patients attending Mount Sinai's clinic completed surveys containing patient-reported outcomes.A total 156 patients survey, at median (range) time 351 days (82-457 days) after infection. All were prevaccination. The most common reported fatigue (n...
Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed information processing and memory. This long-COVID cognitive syndrome shares many features with the cancer therapy-related (CRCI). Neuroinflammation, particularly microglial reactivity consequent dysregulation hippocampal neurogenesis oligodendrocyte lineage cells, is central to CRCI. We hypothesized...
BACKGROUND Randomized controlled trial (RCT) evidence has revealed the efficacy of vagus nerve stimulation (VNS) paired with rehabilitation therapy, over therapy alone, for upper-limb functional recovery after ischemic stroke. However, this technique not yet been described chronic motor deficits hemorrhagic OBSERVATIONS Three years left putaminal intracerebral stroke deficits, a patient was treated VNS enhanced recovery. 6 weeks in-clinic physical resulting in improvement 14 points on...
Introduction: Upper extremity motor impairment and hemiparesis are prevalent following stroke, can impact independence, ability to perform activities of daily living overall quality life.1 While the majority recovery post stroke occurs within initial 3 months, gains continue through chronic stages.2 Evidence has identified vagus nerve stimulation (VNS) paired with intensive rehabilitation as an effective intervention for improving upper (UE) function in persons stroke.3 Utilization...
Introduction: Telehealth was frequently used in the provision of care and remote patient monitoring (RPM) during COVID-19 pandemic. The Precision Recovery Program (PRP) remotely monitored supported patients with their home environment. Materials Methods: This a single-center retrospective cohort study reviewing data acquired from PRP clinical initiative. Results: Of 679 enrolled PRP, 156 were screened by clinician following deterioration symptoms vital signs on total 240 occasions, included...
Abstract N/A - Letter to the Editor
Abstract Post-acute COVID-19 syndrome (PACS) is a collection of persistent and debilitating symptoms lasting weeks to months after acute infection, with fatigue most commonly reported. There controversy surrounding the role exercise programs for this condition, due concerns over potential worsen fatigue. We developed novel physical therapy program known as Autonomic Conditioning Therapy (ACT) PACS, report on preliminary patient-reported outcome (PRO) data from individuals who completed ACT...
Despite the prevalence of dysautonomia in people with Long COVID, it is currently unknown whether COVID routinely accompanied by structural or functional cardiac alterations. In this retrospective observational study, presence echocardiographic abnormalities was assessed. Left ventricular (LV) chamber sizes were correlated to diagnostic categories and symptoms via standardized patient-reported outcome (PRO) questionnaires. A total 203 individuals without pre-existing disease available...
Strict blood pressure (BP) control is a universally accepted therapeutic intervention in the prevention of secondary stroke, yet this remains difficult when patients return home postinjury. This study aimed to investigate application remote patient monitoring (RPM) BP after or who were at immediate risk and subsequent outcomes relating triage escalation care.This was single-center proof-of-concept study. Participants aged 18 years older with diagnosis stroke stroke. Patients enrolled into...
Background and Purpose: Sport-specific training may improve postural control, while repetitive head acceleration events (RHAEs) compromise it. Understanding the neural mechanisms underlying control contextualize changes due to RHAE. The goal of this study was determine whether sway during Balance Error Scoring System (BESS) is related white matter organization (WMO) in collegiate athletes. Methods: Collegiate soccer ( N = 33) non-soccer athletes 44) completed BESS diffusion tensor imaging....
Abstract Introduction Long COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken traditional autonomic rehabilitation to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing exercises require less exertion can potentially improve function. The objective this work was report on the impact a resonant program self-reported symptoms wellbeing in people COVID. Methods A retrospective analysis...
Accumulating evidence and medical guidelines recommend high-dose neurorehabilitation for recovery after stroke. Unfortunately, most patients receive a fraction of this dose, with therapist availability costs delivery being major implementational barriers. To explore potential solution, we conducted retrospective analysis real-world enhanced clinical service that used gamified self-training technologies at home under remote supervision. Data from 17 who completed 12-18 week full-body, program...
BACKGROUND: Advanced technologies are increasingly used to address impaired mobility after neurological insults, with growing evidence of their benefits for various populations. However, certain robotic devices have not been extensively investigated in specific conditions, limiting knowledge about optimal application healthcare. OBJECTIVE: To compare effectiveness conventional gait training exoskeleton-assisted walking non-traumatic brain injury during early stage rehabilitation. METHODS:...
There are 3.8 million sports-related concussions reported annually. Although there is a growing number of concussions, lack evidence-based methods to evaluate, treat, predict, and monitor recovery in athletes. Today, clinically diagnosed using self-reported symptoms by examining posture, neurocognition, ocular/vestibular control, various imaging techniques. The Sport Concussion Assessment Tool (SCAT) widely used on the sideline along with other diagnose concussion. However, current studies...