A5012806330- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Calcium signaling and nucleotide metabolism
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
Stanford University
2022
National Institute of Neurological Disorders and Stroke
2021-2022
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection found white-matter-selective in mice humans. Following mild mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, myelin loss were evident together with...
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function the organelle and generated by action V-type H + ATPase, but other pathways ion movement are required to dissipate voltage this process. ClC-7, Cl - /H antiporter responsible lysosomal permeability, candidate contribute acidification process as part ‘counterion pathway’ signaling lipid PI(3,5)P2 modulates dynamics, including regulating channels, raising possibility that it could...
ABSTRACT The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function the organelle and generated by action V-type H + ATPase, but other pathways ion movement are required to dissipate voltage this process. ClC-7, Cl - /H antiporter responsible lysosomal permeability, candidate contribute acidification process as part “counterion pathway”. signaling lipid PI(3,5)P2 modulates dynamics, including regulating channels, raising possibility that...