A5062935656- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Protease and Inhibitor Mechanisms
- Bacteriophages and microbial interactions
Yale University
2022-2024
Mayo Clinic in Florida
2019
Abstract Post-acute infection syndromes may develop after acute viral disease 1 . Infection with SARS-CoV-2 can result in the development of a post-acute syndrome known as long COVID. Individuals COVID frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions 2–4 However, biological processes that are associated persistence these symptoms unclear. Here 275 individuals or without were enrolled cross-sectional study included multidimensional...
SARS-CoV-2 infection can result in the development of a constellation persistent sequelae following acute disease called post-acute COVID-19 (PASC) or Long COVID 1-3 . Individuals diagnosed with frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions ; however, basic biological mechanisms responsible for these debilitating symptoms are unclear. Here, 215 individuals were included an exploratory, cross-sectional study to perform...
Summary Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present LC after acute SARS-CoV-2 infection 1–7 . However, whether immunological traits underlying differ between sexes, such explain differential symptomology is currently unknown. Here, we performed sex-based multi-dimensional immune-endocrine profiling 165 individuals 8 without an exploratory, cross-sectional study identify key...
COVID-19 vaccines have prevented millions of deaths. Yet, a small fraction the population reports chronic debilitating condition after vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in Yale LISTEN study. Compared controls, exhibited differences immune profiles, including reduced circulating...
Abstract Epitope-based vaccines are promising therapeutic modalities for infectious diseases and cancer, but identifying immunogenic epitopes is challenging. The vast majority of prediction methods sequence-based, do not incorporate wide-scale structure data biochemical properties across each peptide-MHC (pMHC) complex. We present ImmunoStruct, a deep-learning model that integrates sequence, structural, information to predict multi-allele class-I pMHC immunogenicity. By leveraging multimodal...