- Zebrafish Biomedical Research Applications
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Water Treatment and Disinfection
- Neuroscience and Neuropharmacology Research
- Fish Ecology and Management Studies
- Forensic Toxicology and Drug Analysis
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Digital Imaging for Blood Diseases
- Animal testing and alternatives
- Traumatic Brain Injury and Neurovascular Disturbances
- Environmental Chemistry and Analysis
- Helminth infection and control
- Neural dynamics and brain function
- Effects and risks of endocrine disrupting chemicals
- Pregnancy and preeclampsia studies
- Prenatal Substance Exposure Effects
- Aortic Disease and Treatment Approaches
- Domain Adaptation and Few-Shot Learning
- Biochemical Acid Research Studies
- Synthesis of β-Lactam Compounds
- Agricultural safety and regulations
- Psychedelics and Drug Studies
Universitat de Barcelona
2013-2025
Helmholtz Centre for Environmental Research
2016-2022
Universitat Autònoma de Barcelona
2015-2017
Universidade de São Paulo
2015
Detection of developmental phenotypes in zebrafish embryos typically involves a visual assessment and scoring morphological features by an individual researcher. Subjective could impact results be particular concern when phenotypic effect patterns are also used as diagnostic tool to classify compounds. Here we introduce quantitative morphometric approach based on image analysis embryos. A software called FishInspector was developed detect from images collected using automated system position...
Abstract Textile manufacturing is one of the most polluting industrial sectors because release potentially toxic compounds, such as synthetic dyes, into environment. Depending on class their loss in wastewaters can range from 2% to 50% original dye concentration. Consequently, uncontrolled use dyes negatively affect human health and ecological balance. The present study assessed toxicity textile Direct Black 38 (DB38), Reactive Blue 15 (RB15), Orange 16 (RO16), Vat Green 3 (VG3) using...
The antioxidant activity of food compounds is one the properties generating most interest, due to its health benefits and correlation with prevention chronic disease. This usually measured using in vitro assays, which cannot predict vivo effects or mechanisms action. objective this study was evaluate protective six phenolic (naringenin, apigenin, rutin, oleuropein, chlorogenic acid, curcumin) three carotenoids (lycopene B, β-carotene, astaxanthin) naturally present foods a zebrafish embryo...
Disinfection by-products are contaminants produced during drinking water disinfection. Several DBPs have been implicated in a variety of toxic effects, mainly carcinogenic and genotoxic effects. Moreover, exposure has also associated with an increased risk developmental In this study, the toxicity genotoxicity 10 (four trihalomethanes [THMs], five haloacetic acids [HAAs] sodium bromate) zebrafish embryo model were evaluated. Embryos exposed for 72 hours observed different endpoints such as...
Malaria during pregnancy implies a high risk for the mother and developing child. However, therapeutic options pregnant women have historically been very limited, especially first trimester of due to potential adverse effects on embryo-fetal development. Recently, there has great controversy regarding these because results rodent studies were not in accordance with clinical data available, finally WHO changed recommendations uncomplicated P. falciparum malaria treatment...
Background/Objectives: Anticancer research remains a permanent and evolving field of investigation, due to the complexity adaptability cancer. Methods: In this work, we investigated 10 3,3-dichlorolactams for their hemolytic behavior cytotoxic properties against tumor A431 fibroblast 3T3 cells, with focus on selective toxicity. Results: The results demonstrated that all lactams were hemocompatible, cytotoxicity influenced mainly by structure tested concentration. Among different candidates,...
Abstract Reported off‐target effects of antihistamines in humans draw interest ecotoxicity testing first‐ and second‐generation antihistamines, the latter which have fewer reported side humans. Because are ionizable compounds, pH influences uptake toxicity thus is highly relevant when conducting experiments. Zebrafish embryo tests were performed with 3 first‐generation ketotifen, doxylamine, dimethindene 2 cetirizine levocabastine at 5.5, 7.0, 8.0. We detected on survival, phenotype,...
A central element of high throughput screens for chemical effect assessment using zebrafish is the and quantification phenotypic changes. By application an automated more unbiased analysis these changes image analysis, patterns phenotypes may be associated with mode action (MoA) exposure chemical. The aim our study was to explore what extent compounds can grouped according their anticipated toxicological or pharmacological quantitative multi-endpoint test. Chemical-response signatures 30...
The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed embryos to PCB126 or several redox-modulating chemicals study their ability modulate dysmorphogenesis produced PCB126. concentration-dependent induction pericardial edema...
Neuroactive substances are the largest group of chemicals detected in European surface waters. Mixtures neuroactive occurring at low concentrations can induce adverse neurological effects humans and organisms environment. Therefore, there is a need to develop new screening tools detect these chemicals. Measurement behavior or motor rodents fish usually performed assess potential neurotoxicity for risk assessment. However, due pain stress inflicted on animals, scientific community advocating...
The recreational use of MDMA (ecstasy) by pregnant women is associated with impaired neuromotor function in infants, but the Adverse Outcome Pathway behind this effect not clear yet. We present for first time evaluation developmental neurotoxic (DNT) effects zebrafish embryos. aim study was to determine whether model reproduces adverse outcome occurring humans. have studied DNT within a range 5-250 μM performing different behavioural tests: spontaneous tail-coiling and light-dark locomotor...
Chinese herbal medicine (CHM) is used among pregnant women. However, the question of its safety during pregnancy remains unclear. The use these products relies on history data but there are specific toxicities like developmental neurotoxicity that clearly understudied. Here we zebfrafish embryo toxicity assay (ZEDTA) in combination with two behavioral assays: touch-evoked response and Light/Dark (L/D) transition to evaluate neuro/developmental three commonly CHM [Chinese name (abbreviation;...
The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict vivo protective activity or determine their underlying mechanisms action. aim this study was develop an experimental system evaluate effects different compounds, based on zebrafish embryo test. Zebrafish embryos were exposed tert-butyl hydroperoxide (tBOOH), tetrachlorohydroquinone (TCHQ) and lipopolysaccharides from Escherichia coli (LPS), chemicals are known inducers...
Background Fascioliasis and paragonimiasis are widespread foodborne trematode diseases, affecting millions of people in more than 75 countries. The treatment choice for these parasitic diseases is based on triclabendazole, a benzimidazole derivative which has been suggested as promising drug to treat pregnant women children. However, at the moment, this not approved human use most Its potential adverse effects embryonic development have scarcely studied, it assigned pregnancy category by...
The increasing number of new psychoactive substances (NPS) entering the illicit drug market, especially synthetic cathinones, as well risk cardiovascular complications, is intensifying need to quickly assess their cardiotoxic potential. present study aims evaluate toxicity and lethality induced by first-generation cathinones (mephedrone, methylone, MDPV) more classical psychostimulants (cocaine MDMA) in zebrafish embryos using a approach methodology (NAM). Zebrafish at 4 dpf were exposed...
Following a multi-disciplinary approach integrating information from several experimental models we have collected new evidence supporting, expanding and redesigning the AOP "Disrupted laminin/int-β1 interaction leading to decreased cognitive function". Investigations in vitro rabbit rat neurospheres vivo mice exposed EGCG (epigallocatechin-gallate) during neurodevelopment are combined with evaluations neural progenitor cells overexpressing int-β1 literature deficiency models. We discovered...