A5004022454- Synthesis of Organic Compounds
- Natural Compound Pharmacology Studies
- Carbohydrate Chemistry and Synthesis
- Genomic variations and chromosomal abnormalities
- Seaweed-derived Bioactive Compounds
- Microbial Metabolites in Food Biotechnology
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
- Nuclear Structure and Function
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plants and Bioactive Compounds
- Chromatin Remodeling and Cancer
- Cancer Mechanisms and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
Thammasat University
2016-2024
University of Dundee
2010
Abstract Background Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation Ran-GTP by RCC1 on chromatin critical nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Both N-terminal tail its association with are important interaction in cells. In vitro, induces a conformational change that promotes DNA. Results We have investigated mechanism dynamic α isoform human (RCC1α) live cells using...
Genomic alteration in head and neck squamous cell carcinoma (HNSCC) was studied two line pairs (HN30-HN31 HN4-HN12) using conventional C-banding, multiplex fluorescence situ hybridization (M-FISH), array comparative genomic (array CGH). HN30 HN4 were derived from primary lesions the pharynx base of tongue, respectively, HN31 HN12 lymph-node metastatic belonging to same patients. Gain chromosome 1, 7, 11 shared almost all lines. Hierarchical clustering revealed that closely related HN4, which...
Abstract Background Plant-derived compounds have chemopreventive properties to be used as alternative medicine. Pericarp of Mangosteen ( Garcinia mangostana Linn.), a tropical fruit in Southeast Asia contains phytochemical α -mangostin -MG) that demonstrates potent anticancer effects against various types cancer. -MG has been reported the most effective agent human cancer cell lines. The objectives this study were develop oral gel formulations containing α-MG and determine their (1)...
Objective: Many studies suggested that fucoidan has anticancer potential. The objective of the present study was to determine cytotoxic effects and mechanism cell death induced by extracted from Fucus vesiculosus on HSC-3 oral squamous carcinoma. Methods: cells were treated with 0, 100, 200, 400 μg/mL fucoidan. Cell viability measured using MTT assay. Apoptosis cycle a flow cytometry-based Chromatin condensation nuclear fragmentation determined Hoechst 33342 staining. Mitochondrial membrane...
Oral cancer is often preceded by a mucosal lesion called an oral potentially malignant disorder (OPMD). Many plant-derived compounds are of value in medicine. The objectives this study were to develop soluble mucoadhesive film containing α-mangostin (α-MG), compound extracted from the peel mangosteen fruit, and determine its activities against cells, human papillomavirus type 16 (HPV-16) pseudovirus, anti-inflammatory properties.A α-MG was prepared. squamous carcinoma cell line (SCC25),...