A5088892048- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroblastoma Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Nicotinic Acetylcholine Receptors Study
- Protein Degradation and Inhibitors
- Neuroscience and Neuropharmacology Research
- Molecular Biology Techniques and Applications
- Microtubule and mitosis dynamics
- Renal and related cancers
- Cholinesterase and Neurodegenerative Diseases
- Neurofibromatosis and Schwannoma Cases
- ATP Synthase and ATPases Research
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
Memorial Sloan Kettering Cancer Center
2020-2025
Kettering University
2022-2024
State Key Laboratory of Oncogene and Related Genes
2015-2020
Shanghai Jiao Tong University
2014-2020
Renji Hospital
2020
// Yizhou Quan 1 , Naitao Wang Qianqian Chen Jin Xu Wei Cheng 2 Meijuan Di 3 Weiliang Xia and Wei-Qiang Gao 1,4 State Key Laboratory of Oncogenes Related Genes, Renji-MedX Clinical Stem Cell Research Center, Ren Ji Hospital, School Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China Department Urology, First People’s Hospital of Xiaoshan, Hangzhou, Zhejiang, Pathology, 4 Collaborative Innovation Center Systems Biomedicine, Correspondence to: Xia, email: Gao,...
Abstract Purpose: Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance. Experimental design: In this study, IHC was performed detect protein expression mouse tissue sections human sections. Subcutaneously orthotopically xenografted tumor models...
Abstract Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this PRC2-dependent cancers, but an unmet therapeutic need exists PRC2-loss PRC2-inactivating mutations are a hallmark feature high-grade malignant peripheral nerve sheath tumor (MPNST), aggressive sarcoma with poor prognosis no effective targeted therapy. Through RNAi screening MPNST, we found that PRC2 inactivation increases sensitivity to genetic or...
Abstract Members of the KMT2C/D–KDM6A complex are recurrently mutated in urothelial carcinoma and histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c / d knockout urothelium led to impaired differentiation, augmented responses growth inflammatory stimuli sensitization oncogenic transformation by carcinogen oncogenes. Mechanistically, KMT2D localized active enhancers CpG-poor promoters preferentially regulate lineage program diminished...
KMT2C and KMT2D ( KMT2C/D ) are frequently mutated in gastric adenocarcinoma, yet their function cancer initiation remains poorly understood. In this study, based on the observation that loss-of-function mutations of enriched co-occur we developed genetically engineered mouse models to selectively knock out Kmt2c Kmt2d epithelial cells with Tmprss2-CreER T2 . Through histological staining single-cell RNA sequencing, observed Kmt2c/d loss led nuclear dysplasia expansion mixed lineage markers....
The mechanisms underlying
Prostate cancer (PCa) is the most frequently diagnosed for men in developed world. Androgen receptor signaling pathway plays an important role prostate progression. Recent studies show that microRNA miR-124 exerts a tumor suppressive function cancer. However, relationship between AR and unclear. In present study, we found negative feedback loop expression. On one hand, was positively regulated target gene of AR, on other overexpression inhibited expression AR. addition, miR-124-2 miR-124-3...
Although STAT3 signaling is demonstrated to regulate sensory cell differentiation and regeneration in the zebrafish, its exact role still unclear mammalian cochleae. Here, we report that activated form are specifically expressed hair cells during mouse cochlear development. Importantly, conditional deletion of Stat3 leads an inhibition on mice vivo vitro. By fate analysis, inactivation shifts division modes from asymmetric symmetric divisions supporting cells. Moreover, Notch stimulates...
Prostate cancer is the most common type of for men in developed world. Androgen receptor (AR) very important prostate progression. TMPRSS2 an AR signaling downstream gene and closely related to carcinogenesis. DNA methylation a key mechanism influence expression. Though previous reports have shown that plays critical role regulation cancer, hardly any studies examined whether has been involved TMPRSS2. In present study, we demonstrated AR-negative (PCa) cells showed low expression levels...
Regulation of prostate epithelial progenitor cells is important in development and diseases. Our previous study demonstrated a function autocrine cholinergic signaling (ACS) promoting cancer growth castration resistance. However, whether or not such ACS also plays role unknown. Here, we report that promoted the proliferation inhibited differentiation organotypic cultures. These results were confirmed by ex vivo lineage tracing assays renal capsule recombination assays. Moreover, found M3...
Abstract Urothelial carcinoma arises from a “field” of precancerous but histologically normal urothelium. The KMT2C/D-KDM6A complexes known to bind and activate enhancers are frequently mutated in urothelial Here, using genetically engineered mouse model, we demonstrate that knockout Kmt2c and/or Kmt2d induced normal, pre-tumorigenic state characterized by impaired differentiation basal augmented responses growth inflammatory stimuli. This sensitized the urothelium transformation oncogenic...
<div>Abstract<p><b>Purpose:</b> Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance.</p><p><b>Experimental design:</b> In this study, IHC was performed detect protein expression mouse tissue...
<p>Supplementary Figure S3. CHRM3 is up-regulated in CRPC cells.</p>
<p>Supplementary Figure S4. Calcium influx induced by various concentrations of acetylcholine or carbachol.</p>
<p>Supplementary figure legend</p>
<p>Supplementary Figure S1. Analysis of gene expression in Oncomine database and GEO Profiles database.</p>
<p>Supplementary Figure S2. Autocrine activation of CHRM3 promotes cell migration in scratch test.</p>
<p>raw uncropped labeled western blots</p>
<p>Supplementary figures S1-S6 with figure legends.</p>
<div>AbstractPurpose:<p>All uveal melanoma and a fraction of other subtypes are driven by activation the G-protein alpha-q (Gα<sub>q</sub>) pathway. Targeting these melanomas has proven difficult despite advances in molecular understanding key driver signaling pathways disease pathogenesis. Inhibitors Gα<sub>q</sub> have shown promising preclinical results, but their therapeutic activity distinct mutational contexts <i>in vivo</i> remained...
<div>Abstract<p><b>Purpose:</b> Although a previous study reported nerve ending–derived acetylcholine promoted prostate cancer invasion and metastasis by regulating the microenvironment of cells, present aims to determine whether there is autocrine cholinergic signaling in epithelial cells that promotes growth castration resistance.</p><p><b>Experimental design:</b> In this study, IHC was performed detect protein expression mouse tissue...