A5085328347- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- Alcoholism and Thiamine Deficiency
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Infectious Encephalopathies and Encephalitis
- Chromatin Remodeling and Cancer
- Cancer Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Neurological and metabolic disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
The University of Tokyo
2021-2024
University of Tokyo Hospital
2022
Toranomon Hospital
2017
Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic components are captured in the autophagosome and degraded lysosome. Autophagy plays two major roles: nutrient recycling under starvation or stress conditions maintenance of cellular homeostasis by removing damaged organelles protein aggregates. In established cancer cells, autophagy-mediated promotes tumor progression, whereas normal/premalignant autophagy suppresses initiation eliminating oncogenic/harmful...
The molecular subtypes of pancreatic cancer (PC), either classical/progenitor-like or basal/squamous-like, are currently a major topic research because their direct association with clinical outcomes. Some transcription factors (TFs) have been reported to be associated these subtypes. However, the mechanisms by which signatures PCs established remain unknown. Epigenetic regulatory processes, supported dynamic changes in chromatin structure, essential for transcriptional profiles. Previously,...
A 55-year-old man was admitted to our institute undergo evaluation for proteinuria (5.4 g/day) with lambda-type Bence-Jones protein (BJP). Primary amyloid light chain (AL) amyloidosis and acquired factor X deficiency were diagnosed. High-dose melphalan combined autologous stem cell transplantation performed. After three years, the patient's normalized, he negative urinary BJP, his activity improved 105%. Serial renal biopsy showed no progression of deposition at a after 5 but slight increase...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited therapies. In our screening using patient-derived organoids, we identified cyclin-dependent kinase 12 (CDK12) as promising target in subset of PDAC. Both pharmacological and genetic inhibition CDK12 exerted potent antitumor activity vitro vivo, inducing double-strand DNA breaks apoptosis. member kinases that involved gene expression regulations at multiple levels. Recently, has gained attention therapeutic...
Endoscopic ultrasound (EUS)-guided pancreatic drainage is increasingly utilized in cases where endoscopic retrograde cholangiopancreatography (ERCP) not possible [1] [2] [3]. EUS-guided for a non-dilated duct (PD) only poses technical challenges but also increases the risk of procedure-related pancreatitis as well stent-induced ductal injury. A small-caliber stent might be suitable PD to prevent injury and upstream main obstruction, there has been no report on dedicated 5-Fr stent. Herein we...
Abstract Three-dimensional (3D) chromatin structures connect genes to regulatory elements, thereby contributing cell-type-specific gene regulation. However, its role in pancreatic cancer remains unclear. Inspired by our previous finding that open profiles analyzed ATAC-seq well characterize the biological features and transcriptional status of neoplasms, we hereby demonstrate previously overlooked impact 3D epigenetic regulation cancers. Through integrative analysis Hi-C, ChIP-seq, RNA-seq...