A5010396109- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- T-cell and Retrovirus Studies
- interferon and immune responses
- Cutaneous lymphoproliferative disorders research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- TGF-β signaling in diseases
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Veterinary Oncology Research
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- Microbial infections and disease research
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Fungal Infections and Studies
Medical University of Vienna
2018-2024
University of Veterinary Medicine Vienna
2018-2023
Ludwig Boltzmann Institute for Cancer Research
2018
Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C have been detected by whole exome sequencing studies in various cancers, including malignancies prostate. However, biological consequences these alterations prostate cancer not yet elucidated.To investigate functional effects mutations, we deleted C-terminal catalytic core motif Kmt2c specifically mouse epithelium. We analysed effect SET domain deletion a Pten-deficient PCa model vivo and large number patients.We...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify neuroblastoma (NB), we herein employ genome-wide CRISPR activation screens NB lines treated brigatinib or ceritinib, identifying PIM1 as a putative gene, whose high expression is associated high-risk disease and poor survival. Knockdown sensitizes cells differing...
Abstract Background Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T commonly driven by NPM-ALK. AP-1 transcription factors, cJUN and JUNb, act as downstream effectors of NPM-ALK transcriptionally regulate PDGFRβ. Blocking PDGFRβ kinase activity with imatinib effectively reduces tumor burden prolongs survival, although the molecular mechanisms remain elusive. Methods results In a transgenic mouse model that mimics PDGFRβ-driven human ALCL in vivo, we identify driver...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...