A5103184277- Esophageal and GI Pathology
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Blood Coagulation and Thrombosis Mechanisms
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Acute Myeloid Leukemia Research
- Dysphagia Assessment and Management
- Cardiovascular Disease and Adiposity
- Eosinophilic Disorders and Syndromes
- Gastric Cancer Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- IgG4-Related and Inflammatory Diseases
- Blood disorders and treatments
- Carbohydrate Chemistry and Synthesis
- Bone and Joint Diseases
- Systemic Lupus Erythematosus Research
- Hemophilia Treatment and Research
- Hemostasis and retained surgical items
- HIV/AIDS drug development and treatment
- Nutritional Studies and Diet
- RNA modifications and cancer
Saitama Children's Medical Center
2017-2022
Kobe Children's Hospital
2020
National Center For Child Health and Development
2017
Tokyo Gas (Japan)
2007-2015
University of South Carolina
2007
Chukyo University
2007
Dokkyo University
2007
Kindai University
1991-1998
Institute for Animal Reproduction
1993
Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence type 2 diabetes, there are no data on long-term trends in and risk. We investigated the relationship between diabetes.A cohort 4,187 Japanese men free diabetes completed annual health checkups tests for estimated maximal oxygen uptake at least four times over 7 years (1979-1985). modeled trend each man using simple linear regression. Men were then divided into quartiles based regression...
A rat colony with mucopolysaccharidosis VI was established and the clinical, pathological, biochemical features were characterized. Affected rats had facial dysmorphia, dysostosis multiplex, increased urinary excretion of glucosaminoglycans (GAGs). Ultrastructural studies revealed storage GAGs throughout reticuloendothelial cells, cartilage, other connective tissues, but no deposition observed in nervous system. Biochemical analyses demonstrated that excreted GAG dermatan sulfate activity...
BackgroundWhile heavier weight is known to increase the incidence of dyslipidemia, limited data are available on relationship between gain and its development.
Diamond–Blackfan anemia (DBA) is a rare blood disorder characterized by failure of the bone marrow to produce enough red cells (RBC), and various congenital anomalies.1 DBA must be differentiated from other anemias with low reticulocyte count. Parvovirus B19 infection in utero may associated pure RBC aplasia infancy, even hydrops fetalis at birth,2 but it difficult discriminate between two disorders infants born mothers intrauterine parvovirus infection. In present case we were able...
Despite the growing evidences that immune dysfunction contribute to tumor progression, prognostic value in patients with neuroblastoma regarding circulating blood cell counts has not been well characterized. To answer this, we conducted a retrospective study evaluate of at diagnosis cohort 55 neuroblastoma. Based on novel index by multiplying absolute monocyte count (AMC) /μl and lymphocyte (ALC) /μl, sub-grouped AMC × ALC ≥ 1 106 (/μl)2 as high group < low group. In entire cohort, 4-year...
Gastric emptying, upper esophageal sphincter pressure and intrathoracic gastric motility were studied in esophagectomized patients, ten with a conduit the posterior mediastinum retrosternal space. In addition, clinical state was reassessed more than 6 months after reconstruction. assessed Tc-99m Sn colloid semisolid test meal, did not differ between two groups. manometric studies high-pressure zone distal to associated dysphagia. A at anastomosis found 60% of group 20% mediastinal group. As...
Gilteritinib is an FMS-like tyrosine kinase 3 (FLT3) inhibitor that has shown efficacy in patients with refractory or recurrent adult acute myeloid leukemia (AML) FLT3 mutations. However, there are limited data for pediatric treated this drug. Herein, we report the clinical courses of two children FLT3-mutated AML who received gilteritinib. Case 1: An 11-year-old boy secondary relapsed presented internal tandem duplication (ITD) since first recurrence. One week after gilteritinib initiation,...
Perioperative management of severe congenital protein C deficiency remains unestablished. This is often treated with anticoagulants, such as warfarin. Although anticoagulants need to be perioperatively discontinued, there are few methods for the patients. We adopted a method administering prothrombin complex concentrates (PCC), which includes intermittent administration inactive (PPSB-HT), and examined its outcome perioperative approach deficiency. Three patients underwent our six times....
A few prospective studies have assessed the joint influences of cardiorespiratory fitness (CRF) and body mass index (BMI) on all-cause mortality, but such are not currently available in Asian populations. PURPOSE: To investigate CRF BMI mortality among Japanese male workers. METHODS: We evaluated risks 9,039 (Age: 19–59 yr) healthy men who were given a submaximal exercise test, medical examination, questionnaires their health habits between 1982 1988. was measured using cycle ergometer...
Several studies show an inverse relationship between cardiorespiratory fitness (CRF) and all-cause mortality. However, limited data are available on the muscular performance (MPF) PURPOSE: To investigate association MPF mortality among Japanese men. METHODS: A cohort of 7,072 men (age: 19-59 yr) completed several tests, medical examinations, questionnaires regarding their health habits in 1983. index composite score was calculated using quartiles from vertical jump (muscular power), sit-ups...
食道胃接合部病変の代表的運動機能不全症である,食道裂孔ヘルニアとアカラシアの食道運動機能を,術前後の内圧測定により,比較検討した.また食道筋層の病理組織学的検討と,手術成績についても併せて評価した.その結果,以下のような結論を得た.食道裂孔ヘルニアによる逆流性食道炎の原因として,胃内圧の上昇と,第1次蠕動波の異常による下部食道の排出障害が大きく関与していると考えられた.手術によってlower esophageal sphincter(LES)の圧と長さは回復したが,蠕動運動障害は残存した.狭窄症状を有する例では,下部食道筋層のAuerbach神経叢に変性があり,Nissen法では有効な結果のえられないことがあった.食道アカラシアの術後LESの機能改善はえられたが,蠕動運動の障害は残った.アカラシアの病態病理として,myenteric plexusの変性の他に,神経線維や軸索の変性による神経伝達輸送の障害の関与も推察された.
The histologic changes of 5.0×0.5 cm surgical specimens the lower esophageal musculature resected in 7 patients with shortening or stenotic esophagus as a result chronic reflux esophagitis were studied. In regard to histopathological muscle layer esophagitis, there was no specificity inflammatory cellular compositions. However, extensive interstitial fibrosis and degeneration ganglion cells Auerbach's plexus recognized all cases. morphologic characterized by atrophy, swelling, vacuolization,...
As compared with patients submucosal (sm) cancer of the stomach, prognosis submuscosal esophagus is extremely poor. A total 19 superficial carcinoma were reviewed regard to their roentgenologic, endoscopic, histophatological findings and surgical outcome. Five had epitelial (ep) or muscularis mucosae (mm) tumours that could not be detected roentegenographically except for one mm tumour was shown a large polypoid lesion. Most an endoscopic diagnosis flat type by iodine staining method. All...