A5073089603- interferon and immune responses
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Immunotherapy and Immune Responses
- Healthcare innovation and challenges
- Health Systems, Economic Evaluations, Quality of Life
- Melanoma and MAPK Pathways
- Trace Elements in Health
- Cancer Genomics and Diagnostics
- Synthesis and biological activity
- Click Chemistry and Applications
- Histone Deacetylase Inhibitors Research
- demographic modeling and climate adaptation
- Genomics and Rare Diseases
- Adolescent and Pediatric Healthcare
- Toxoplasma gondii Research Studies
- Phytochemicals and Medicinal Plants
- Health disparities and outcomes
- Ethics in Clinical Research
- Acute Lymphoblastic Leukemia research
- Ophthalmology and Visual Impairment Studies
- Molecular Biology Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- X-ray Diffraction in Crystallography
Macquarie University
2017-2024
Impact
2023
UNSW Sydney
2012-2022
Children's Cancer Institute Australia
2009-2022
Cancer Institute of New South Wales
2021
The University of Sydney
2017
Hacettepe University
2014
National Cheng Kung University
2012
National University of Singapore
2003-2005
Identification of the novel (E)-N'-((2-chloro-7-methoxyquinolin-3-yl)methylene)-3-(phenylthio)propanehydrazide scaffold 18 has led to development a new series biologically active hydrazide compounds. The parent compound and quinoline derivatives 19-26 were prepared from corresponding hydrazones substituted carboxylic acids using EDC-mediated peptide coupling reactions. Further modification was achieved by replacement moiety with other aromatic systems. All newly synthesized compounds...
Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression MycN oncoprotein in precursor cells causes postnatal rests, and later tumor formation through unknown mechanisms. However, Myc adult tissues normally activates apoptosis and/or senescence signals as an organismal defense mechanism against cancer. Here, we show that perinatal neuroblastoma exhibited a transiently...
Abstract Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge clinical practice. In this study, we evaluated the efficacy of Withaferin A (WFA), derived from medicinal plant Withania Somnifera , as therapeutic agent for melanoma. WFA showed toxicity cells compared non-malignant cells. induced apoptosis, significantly reduced cell...
The family of tripartite-motif (TRIM) proteins are involved in diverse cellular processes, but often characterized by critical protein–protein interactions necessary for their function. TRIM16 is induced different cancer types, when the cell forced to proceed down a differentiation pathway. We have identified as DNA-binding protein with histone acetylase activity, which required retinoic acid receptor β2 transcriptional response retinoid-treated cells. In this study, we show that...
Abstract Retinoid therapy is used for chemo‐prevention in immuno‐suppressed patients at high risk of developing skin cancer. The retinoid signalling molecule, tripartite motif protein 16 (TRIM16), a regulator keratinocyte differentiation and tumour suppressor retinoid‐sensitive neuroblastoma. We sought to determine the role TRIM16 squamous cell carcinoma (SCC) pathogenesis. have shown that expression was markedly reduced during histological progression from normal actinic keratosis SCC. SCC...
High basal or induced expression of the tripartite motif protein, TRIM16, leads to reduce cell growth and migration neuroblastoma skin squamous carcinoma cells. However, role TRIM16 in melanoma is currently unknown. protein levels were markedly reduced human lines, compared with normal epidermal melanocytes due both DNA methylation stability. knockdown strongly increased melanocytes, while overexpression proliferation cells an interferon beta 1 (IFNβ1)-dependent manner. Chromatin...
This review discusses the evolution of microsimulation models in health over past three decades. We focus on aspects microsimulation. First, we describe origins and applications microsimulation, including how early research challenged methodologies led to development more rigorous models. limitations means-based detailed methods, which are based health-specific input data, overcame many data shortfalls assumptions. Second, discuss global expansion last ten years. Many have focussed...
Abstract Objectives To estimate the health care and societal costs of inherited retinal diseases (IRDs) in Australia. Design, setting, participants Microsimulation modelling study based on primary data — collected interviews people with IRDs who had ophthalmic or genetic consultations at Children's Hospital Westmead Save Sight Institute (both Sydney) during 1 January 2019 – 31 December 2020, their carers spouses linked Medicare Benefits Schedule (MBS) Pharmaceutical (PBS) data. Main outcome...
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma squamous cell carcinoma cells, reducing migration replication. Reduced expression a range of human primary malignant tissues correlates increased potential. also induces apoptosis breast lung cancer unknown mechanisms. Here we show that overexpression (MCF7) (BE(2)-C) but not non-malignant HEK293 cells. procaspase-2 protein levels MCF7 induced caspase-2 activity...
Histone deacetylase (HDAC) inhibitors are effective in MYCN-driven cancers, because of a unique need for HDAC recruitment by the MYCN oncogenic signal. However, much more combination with other anti-cancer agents. To identify novel compounds which act synergistically inhibitor, such as suberanoyl hydroxamic acid (SAHA), we performed cell-based, high-throughput drug screen 10,560 small molecule from drug-like diversity library and identified compound (SE486-11) enhanced cytotoxic effects...
To evaluate the impact of inherited retinal diseases (IRDs) on quality life (QoL) using multiattributable health utilities derived from primary patient data.Cross-sectional observational study.Seventy adult patients (mean age, 42.7 years) with IRD recruited state-wide services in Australia.Health utility values were calculated Assessment Quality Life 8-Dimension (AQoL-8D). Linear regressions used to analyze relationship between 25-item and 39-item National Eye Institute Visual Function...
Abstract Retinoids are an important component of neuroblastoma therapy at the stage minimal residual disease, yet 40–50% patients treated with 13‐cis‐retinoic acid (13‐cis‐RA) still relapse, indicating need for more effective retinoid therapy. Vorinostat, or Suberoylanilide hydroxamic (SAHA), is a potent inhibitor histone deacetylase (HDAC) classes I & II and has antitumor activity in vitro vivo. Fenretinide (4‐HPR) synthetic which acts on cancer cells through both nuclear receptor...
The mitochondrion is a gatekeeper of apoptotic processes, and mediates drug resistance to several chemotherapy agents used treat cancer. Neuroblastoma common solid cancer in young children with poor clinical outcomes following conventional chemotherapy. We sought druggable mitochondrial protein targets neuroblastoma cells. Among mitochondria-associated gene targets, we found that high expression the adenine nucleotide translocase 2 (SLC25A5/ANT2), was strong predictor patient prognosis...
The majority of patients diagnosed with neuroblastoma present aggressive disease. Improved detection cancer cells following initial therapy may help in stratifying patient outcome and monitoring for relapse. To identify potential plasma biomarkers, we utilised a liquid chromatography-tandem mass spectrometry-based proteomics approach to detect differentially-expressed proteins serum from TH-MYCN mice. mice carry multiple copies the human MYCN oncogene germline homozygous transgene develop...
Embedding precision medicine in paediatric oncology shows promise to have a positive impact on how children with cancer will be treated the future. While there are number of studies childhood cancer, is limited evidence available cost implementing related testing. This first Australian study that systematically measures using care high-risk cancers, through Zero Childhood Cancer Precision Medicine Programme. In 2021 dollars, estimated costs inclusive genomic and preclinical testing were: (A)...
The tripartite motif (TRIM)16 acts as a tumour suppressor in both squamous cell carcinoma (SCC) and melanoma. TRIM16 is known to be secreted by keratinocytes, but no studies have been reported yet assess the relationship between keratinocyte expression melanoma development. To study role of skin cancer development, we developed TRIM16-specific knockout mouse model, used classical two-stage carcinogenesis challenge method, loss on papilloma, SCC development after topical carcinogen treatment....
// Selina K. Sutton 1, 2 , Daniel R. Carter Patrick Kim Owen Tan 1 Greg M. Arndt Xu Dong Zhang 3 Jonathan Baell 4 Benjamin D. Noll 5 Shudong Wang Naresh Kumar 6 Grant A. McArthur 7 Belamy B. Cheung Glenn Marshall 2, 8 Children's Cancer Institute for Medical Research, Lowy Research Centre, University of New South Wales, Australia School Women's and Health, UNSW Australia, Priority Centre Oncology Immunology Unit, Newcastle, Department Medicinal Chemistry, Faculty Pharmacy Pharmaceutical...
28 new 3-(4-fluorophenyl)-5-aryl-N-substituted-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives were synthesized and evaluated in vitro for their monoamine oxidase (MAO) A B inhibitory activity selectivity. The substituted by halogen on the fifth position of pyrazole ring, inhibited MAO-A enzyme with a high selectivity index. On other hand, compounds 2-naphthyl MAO-B moderate Docking studies done to highlight interactions most active derivative site MAO-A. In addition, vivo...
Most of the studies on cost intellectual disability are limited to a healthcare perspective or cohorts composed individuals where etiology condition is mixture genetic and non-genetic factors. When used in policy development, these can impact decisions made optimal allocation resources. In our study, we have developed static microsimulation model estimate healthcare, societal, lifetime with familial disability, an inheritable form condition, families government. The results from modeling...
Abstract The family of tripartite-motif (TRIM) proteins is involved in diverse cellular processes, ranging from innate immunity, oncoprotein, and tumor suppressor roles. TRIM16 overexpression confers retinoid sensitivity retinoid-resistant cancer cells. Previously, we found a strong correlation between loss expression disease progression two human cancers: neuroblastoma squamous cell carcinoma skin. Moreover, acted as both cancers through effects on cycle migration. Here examined the...