A5030043134- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Ubiquitin and proteasome pathways
- Toxoplasma gondii Research Studies
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
Vall d'Hebron Institut de Recerca
2022
Universitat Autònoma de Barcelona
2022
Universitat de Barcelona
2022
Overcoming resistance is one of the most challenging features in current anticancer therapy. Autophagy a cellular process that confers some advanced tumors, since it enables cancer cells to adapt stressful situations, such as treatments. Hence, inhibition this cytoprotective autophagy leads tumor sensitization and death. In regard, we designed novel potent anionophore compound specifically targets lysosomes, called LAI-1 (late-stage inhibitor-1), evaluated its role blocking potential effects...
Abstract Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this contribute to the initiation of embryonal tumour development. In neuroblastoma, neural crest progenitors block their course natural differentiation into sympathoadrenergic cells, leading aggressive metastatic paediatric cancer. Research epigenetic regulators responsible oncogenic epigenomic networks crucial developing new epigenetic-based therapies against these...
Abstract Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this contribute to the initiation of embryonal tumour development. In neuroblastoma, neural crest progenitors block their course natural differentiation into sympathoadrenergic cells, leading aggressive metastatic paediatric cancer. Research epigenetic regulators responsible oncogenic epigenomic networks crucial developing new epigenetic-based therapies against these...