A5042718476- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Nanoparticle-Based Drug Delivery
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Angiogenesis and VEGF in Cancer
- Acute Ischemic Stroke Management
- Cardiac Valve Diseases and Treatments
- Cancer Treatment and Pharmacology
- Hemodynamic Monitoring and Therapy
- Cardiac and Coronary Surgery Techniques
- Vascular anomalies and interventions
- Integrated Circuits and Semiconductor Failure Analysis
- Spectroscopy and Quantum Chemical Studies
- Mathematical Biology Tumor Growth
- Vagus Nerve Stimulation Research
- Lipoproteins and Cardiovascular Health
- Protein purification and stability
- Central Venous Catheters and Hemodialysis
New England Center for Children
2019
Harvard University
2005-2018
Brigham and Women's Hospital
2005-2018
Massachusetts Institute of Technology
2004-2017
IIT@MIT
2008-2017
Concord Consortium
2015
Harvard–MIT Division of Health Sciences and Technology
2003-2013
Draper Laboratory
2013
University of South Carolina
2013
Society for Science & the Public
2012
Background— The intricacies of stent design, local pharmacology, tissue biology, and rheology preclude an intuitive understanding drug distribution deposition from drug-eluting stents (DES). Methods Results— A coupled computational fluid dynamics mass transfer model was applied to predict for single overlapping DES. Drug appeared not only beneath regions arterial contact with the strut but surprisingly also standing pools created by disruption flow. These correlated areas drug-induced fibrin...
Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD).We evaluated the effects of orbital atherectomy on paclitaxel human arteries with substantial calcified plaque.Diagnostic angiography and 3-D rotational imaging five fresh lower limbs revealed calcification all main arteries. The proximal or distal segment each was treated using an system (OAS) under simulated blood flow fluoroscopy. Explanted arterial segments underwent either...
Background— Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention remain poorly characterized. Most systems to date have paclitaxel, touting its propensity associate with various excipients that can optimize transfer retention. We examined zotarolimus pharmacokinetics. Methods Results— Animal studies, bench-top experiments, computational modeling were integrated quantify arterial distribution after zotarolimus-coated...
Local tissue anatomy determines the success of renal nerve ablation and explains its variable effects on blood pressure.
Abstract Background: Local drug delivery has transformed medicine, yet it remains unclear how efficacy depends on physicochemical properties and kinetics. Most therapies seek to prolong release, recent studies demonstrate sustained clinical benefit following local bolus endovascular delivery. Objectives: The purpose of the current study was examine interplay between dose, diffusion binding in determining tissue penetration effect. Methods: We introduce a quantitative framework that balances...
Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of delivery. A novel, absorbable-coating sirolimus-eluting (AC-SES) was evaluated for its capacity deliver more evenly within intimal area rather than concentrating around struts and ability match coating erosion release. The consisted absorbable poly-lactide-co-glycolic acid (PLGA) crystalline sirolimus deposited by a dry-powder electrostatic process. AC-SES demonstrated enhanced stability under...
Renal denervation is optimised when guided by knowledge of nerve distribution.
Background/Objective: Paclitaxel-coated balloons (PCBs) can deliver efficacious drug concentrations to treated arterial segments but are known exhibit high tracking losses. We aimed define the governing factors impacting loss and contrast its distribution consequences with those of PCB inflation at treatment site. Methods: Four naïve four in-stent restenosis (ISR) porcine superficial femoral arteries (SFA) were PCBs, plasma samples collected post-tracking post-inflation. Animals sacrificed...
Stat5 signaling in erythroblasts can assume either a binary, low-intensity form, essential for basal erythropoiesis, or graded, high-intensity response, restricted to early and erythropoietic stress.
Abstract Drug-Coated Balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies revealed limited, non-uniform coating transfer onto the arterial lumen. In vitro data suggested that local tracks Contact Pressure (CP) between balloon and endothelium. Therefore, this work aimed investigate in silico how different interventional device parameters may affect spatial distribution of CP during inflation an angioplasty within...
Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel the whole tumor at different loads and rates has already been achieved, determining an optimal release mode for eradication remains difficult. This study set out rationally design such microsphere based on mathematical modeling.A computational reaction-diffusion framework was used...
With increasing attention to renovascular causes and targets for hypertension there arises a critical need more detailed knowledge of renal arterial anatomy. However, standardised nomenclature is lacking. The present study sought develop anatomy considering the complexity variation tree assess applicability nomenclature.One thousand hypertensive patients underwent invasive selective artery angiography in nine centres. Further, renovasography was performed 249 healthy swine as surrogate...