A5022966638- HIV Research and Treatment
- Vector-Borne Animal Diseases
- Immunotherapy and Immune Responses
- HIV/AIDS Research and Interventions
- Cancer Immunotherapy and Biomarkers
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Interprofessional Education and Collaboration
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Global Health and Surgery
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- Global Health Workforce Issues
- Esophageal Cancer Research and Treatment
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Innovations in Medical Education
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- Cultural Competency in Health Care
- Cancer-related Molecular Pathways
- Healthcare Systems and Technology
- Insect and Pesticide Research
- BRCA gene mutations in cancer
Moi University
2013-2025
Kenya Agricultural Research Institute
1989-1995
Esophageal cancer at Moi Teaching and Referral Hospital (MTRH) is the leading in men with a poor prognosis. A case control study<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo stretchy="false">(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>159</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math>aimed histology type, gender, risk indicators was carried out MTRH. Mantel Haenszel chi-square logistic regression were employed for analysis. Squamous-cell carcinoma...
Background: Tuberculosis (TB) and HIV co-infections have a global prevalence with devastating morbidity massive mortality, Sub-Saharan Africa being the worst hit.Objectives: To evaluate of TB-HIV co-infection demonstrate confusion caused by NTM HIV/AIDS in TB diagnosis treatment western Kenya.Methods: In cross-sectional study carried out at 10 hospitals Kenya, sputa from consenting 872 suspects underwent microscopy, culture on Lowenstein-Jensen Mycobacteria Growth Index Tube media. Isolates...
Viral hepatitis is a major concern worldwide, with A (HAV) and E (HEV) viruses showing sporadic outbreaks while B (HBV) C (HCV) are associated chronic hepatitis, cirrhosis hepatocellular carcinoma. The present study determined the proportion, geographic distribution molecular characterization of among patients seeking medical services at hospitals throughout Kenya. Patients presenting jaundice four selected were recruited (n = 389). Sera tested for presence antibody to through E, HBV surface...
Breast cancer incidence and mortality vary significantly among different nations racial groups. African have the highest breast rates in world, even though are below those of many nations. Differences disease progression suggest that aggressive tumors may harbor a unique molecular signature to promote progression. However, few studies investigated pathology clinical markers expressed tissue from regional patient populations. We collected 68 malignant 89 non-cancerous samples Kenyan tissue....
Introduction: Obtaining informed consent from study participants and disseminating the findings responsibly is a key principle required for ethically conducted clinical genetic research. Reports African researchers providing feedback on insights gained during return of whole exome sequencing results to in resource-limited settings lacking. Aim: The empirical process used fill this gap relation BRCA1/2 mutation screening provided unique incorporated into pathology-supported testing algorithm...
This was a prospective study conducted at the Moi Teaching and Referral Hospital, Eldoret, Kenya. Twenty-three children admitted to hospital with cerebral (CM) 10 non-cerebral malaria (NCM) were studied. The aim of establish compare levels tumour necrosis factor (TNF-alpha) transforming growth (TGF-beta1) in these children. Serum cerebrospinal fluid (CSF) cytokine assayed using ELISA kits. In serum, TGF-beta1 TNF-alpha decreased over 5 days after admission both groups patients CM NCM. CSF...
Squamous Cell Carcinoma of Esophagus is one the most common malignancies in both men and women eastern south-eastern Africa. In Kenya, clinical observations suggest that this cancer frequent Rift Valley area. However, so far, there has been no report on molecular characteristics esophageal squamous cell carcinoma (ESCC) area.We have analyzed TP53 mutations, presence human papilloma virus (HPV) DNA expression inflammation markers Cyclooxygenase 2 (Cox-2) Nitrotyrosine (NTyR) 28 cases (13...
Tumors commonly are infiltrated by leukocytes, or tumor infiltrating leukocytes (TILs). It remains unclear, however, if the density and type of individual TILs has a direct simply correlative role in promoting poor prognosis breast cancer patients. Breast Kenyan women is aggressive with presentation at young age, advanced grade (grade III), large size (>2.0 cm), prognosis. We previously observed that tumors were predominantly estrogen receptor positive (ER+) but also included both high...
Background: Blood transfusion is an essential component of modern health care. It required universally to manage various medical, surgical and obstetric conditions. Establishing the profiles blood recipients would help in predicting long term needs as changing patterns populations, diseases care will result demands for components. The objective study was determine pattern use terms demographic clinical recipients. Methods: A hospital based medical chart review 384 patients who were...
The advent of antiretroviral treatment (ART) has resulted in a dramatic reduction AIDS-related morbidity and mortality. However, the emergence spread drug resistance (DR) threaten to negatively impact regimens compromise efforts control epidemic. It is recommended that surveillance occur conjunction with scale-up ensure appropriate first-line therapy offered relative exists. standard testing methods used Sub-Saharan Africa rely on techniques do not include low abundance DR variants (LADRVs)...
Burkitt's lymphoma (BL) is a common aggressive non-Hodgkin's in East and Central Africa among children. Persistent infections with Epstein Barr virus or Plasmodium falciparum are associated immune hyperstimulation. It hypothesised that inadvertent cytokine responses to indirectly directly influence B cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. We sought describe cytokines children adolescents BL. Participants were recruited from western Kenya...
Background. To date the effect of pregnancy on immune activation CD8 T cells that may affect HIV disease progression has not been well studied and remains unclear. Objective. determine lymphocyte its relationship with CD4 count in infected pregnant women. Study Design. Case control. Site. AMPATH MTRH Eldoret, Kenya. Subjects. Newly diagnosed asymptomatic positive nonpregnant women no prior receipt antiretroviral medications. Methods. Blood samples were collected from study participants...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934 Icahn School Medicine...
There are few accurate prognostic indications of the illness’s development and severity for COVID-19, despite certain biomarkers having been investigated. The unexpected nature COVID-19’s course, which can quickly progress from asymptomatic to severe disease, lies at heart disease’s intricacy. Predicting SARS-CoV-2 pathogenicity through laboratory as such, identifying patients’ illness time initial admission would be crucial in aiding patient care. In this study, we sought evaluate...
Burkitt's lymphoma (BL) is a frequent childhood B cell non-Hodgkin's (NHL) in equatorial Africa associated with infections. Chronic Epstein Barr virus (EBV) infections can lead to host immune stimulation that may trigger genetic translocation(s), neoplastic transformation and proliferation of cells. We determined EBV immunoglobulin G (IgG) sera from participants EBER-1 tumour sections confirmed BL cases at Moi Teaching Referral Hospital (MTRH). A cross sectional study children clinical...