A5045013549- Heart Rate Variability and Autonomic Control
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Non-Invasive Vital Sign Monitoring
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- EEG and Brain-Computer Interfaces
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Coronary Interventions and Diagnostics
- Advanced Chemical Sensor Technologies
- Vagus Nerve Stimulation Research
- Analog and Mixed-Signal Circuit Design
- Cancer and biochemical research
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
- Comparative Animal Anatomy Studies
Kurashiki Central Hospital
2023-2025
Kobe City Medical Center General Hospital
2020-2022
Fukuyama University
2021
National Cerebral and Cardiovascular Center
1988-2008
Muroran Institute of Technology
2004
SPring-8
2004
Japan Synchrotron Radiation Research Institute
2004
Cardiovascular Institute Hospital
1983
Hemodialysis (HD) is associated with adverse cardiovascular events after percutaneous coronary intervention (PCI). Although the ultrathin strut biodegradable polymer sirolimus-eluting stent (ultrathin BP-SES) has had better results in patients undergoing PCI compared other drug-eluting stents (DES), its usefulness HD unknown. This study involved 286 lesions 162 who underwent a DES between January 2018 and June 2022. The incidence of clinically driven target lesion revascularization (TLR),...
The effects of pentobarbital and chloralose on cardiac sympathetic nerve activity (CSNA), renal (RSNA), arterial pressure (AP), heart rate (HR) were examined using conscious cats. Arterial blood was sampled intermittently to measure plasma epinephrine. Pentobarbital (25-30 mg/kg iv) decreased CSNA, RSNA, AP, HR. reduction CSNA (71 +/- 7%) larger lasted longer than that RSNA (33 12%). Chloralose (40-50 66 9% HR, increased 127 122%, did not affect AP. baroreflex relationship between AP by...
Patients with nonvalvular atrial fibrillation (AF) not suitable for long-term anticoagulant therapy undergo percutaneous left appendage closure (LAAC) using the WATCHMAN device. The safety and efficacy of WATCHMAN-FLX (WM-FLX) compared WATCHMAN-2.5 (WM-2.5), particularly in Asian populations, is unknown.
To examine the mechanism of cardiac-related sympathetic discharge, periodicity synchronized cardiac nerve activity (CSNA) was measured in awake cats before and after baroceptor denervation using an interval histogram. We found two major periodicities, i.e., Tc = 48-164 ms (20-6 cycles/s) Tb 164-512 (6-2 cycles/s). In baroceptor-intact state, modes (C) (B) were 96 (10 368 (2.7 cycles/s), respectively, whereas (CI) 366 Probability B mode larger than that C mode. During tachycardia by atropine,...
Responses in efferent cardiac sympathetic nerve activity (CSNA) and heart rate (HR) to a 100-s anterior descending coronary artery occlusion were measured cats under awake, atropinized, anesthetized, or anesthetized atropinized states. In the conscious state, at 20 90 s of occlusion, CSNA increased by 23% then decreased 7%, respectively, whereas HR 5 17%, respectively. With atropinization and/or anesthesia, initial increase was inhibited later decrease enhanced, bradycardia diminished....
Background The natural history and optimal interventional timing in patients with isolated severe tricuspid regurgitation (TR) have not been well studied. This study aimed to investigate long-term clinical outcomes risk factors associated poor prognosis TR. Methods Results Consecutive transthoracic echocardiographic examinations 2877 TR were retrospectively reviewed. Patients significant left-sided valve disease or repeated excluded. Primary outcome was defined as a composite of all-cause...
Changes in efferent sympathetic nerve activity to the pulmonary vessels during systemic hypoxia have yet be elucidated. The purpose of this study was determine (PSNA) changes response acute before and after sinoaortic denervation plus vagotomy anesthetized cats. performed estimate central nervous system-mediated peripheral chemoreceptor- baroreceptor-independent PSNA change. recorded from end cut bundle, which isolated lobar artery supplying diaphragmatic lobe. Renal (RSNA) arterial...
AbstractWe measured simultaneously and continuously the sympathetic nerve activity to heart (CSNA) kidney (RNA) together with rate (HR) arterial blood pressure (AP) in conscious cats. The time course magnitude of their responses behavioral stimuli norepinephrine iv administration were analyzed quantitatively. increases CSNA RNA occurred almost onset standing, walking or eating behavior. abrupt not preceded by a decrease AP so it was unlikely have been reflex initiated baroceptors. Rather,...
Synchrotron radiation has been used to analyze crossbridge dynamics in isolated papillary muscle and excised perfused hearts with the use of x-ray diffraction techniques. We showed that these techniques can detect regional changes rat left ventricle contractility myosin lattice spacing situ ejecting real time. Furthermore, we examined sensitivity indexes ischemia.The ventricular free wall spontaneously beating (heart rate, 290 404 bpm) was directly exposed brief high-flux, low-emittance...
Cardiac sympathetic nerve activity (CSNA in imp/s) was measured the postganglionic fibers of awake cats at rest, during body movement, and with excitement. The CSNA showed synchronized discharges various periodicities. Rhythms were analyzed by an interval histogram (IIH). IIH a multimodal distribution. first model (Tc) range 75 to 125 ms. An 8-12 cycle/s Tc rhythm, i.e., inverse value Tc, always observed cat rest movements. Probability rhythm smallest increased largest These results...
Previous experiments showed the cases in which end ejection of ventricle did not always coincide with systole as identified by time for Emax corresponding to maximally contracted pressure-volume relationship line ventricle. The purpose present study is obtain a better insight into ventricular afterloading conditions that enable simulation method. left was simulated time-varying elastance, E(t), and afterload constant pressure connected via valve resistance R inertance L series. A sinusoidal...
A multichannel telemetry system was developed for use with chronically instrumented unrestrained cats. This can simultaneously record efferent and afferent cardiovascular neural signals, bioelectrical noise arising near the electrode recording EEG, ECG, a standard calibration signal. The miniature (18 cm3), lightweight (24 g), telemeter is five-channel, time-multiplexed, pulse width modulation (PWM)/FM device employing high frequency subcarrier (60 kHz) two sampling frequencies (30 kHz 6...
Abstract We used DNA metabarcoding to assess the seasonal diets of large Japanese wood mouse, Apodemus speciosus (Muridae, Rodentia), in forest edges adjacent citrus orchards on Innoshima Island, Japan. one chloroplast and three mitochondrial barcoding markers determine mouse diets. Among various plant invertebrate diets, A. typically consumed Chinese cork oak ( Quercus variabilis ) early spring (likely acorns preserved during winter) gypsy moths Lymantria dispar , a pest) late summer. In...
The effects of baroceptor reflex on mean cardiac (MCSNA) and renal sympathetic nerve activity (MRNA) were analyzed before after atropinized (0.1mg/kg, i.v.) states in conscious cats at rest. Resting values MCSNA, MRNA, aortic pressure (MAP), heart rate (HR) 85±6imps/s, 76±11imps/s, 100±4mmHg, 164±10beats/min, respectively. Both MCSNA MRNA changed almost inversely to changes the absolute MAP range 90-140mmHg. Within this gain baroceptor-sympathetic system kidney was 2.31 1.84, as well reduced...
Abstract Background Currently, no consensus has been established on the most effective antithrombotic therapy to prevent thromboembolic and bleeding events in patients undergoing percutaneous left atrial appendage closure (LAAC). Methods We retrospectively investigated incidence of device-related thrombosis (DRT), events, who underwent LAAC from September 2019 October 2022. After categorizing into groups based preprocedural or under oral anticoagulation (OAC) therapy, we compared DRT...
BACKGROUND: A small mitral valve area (MVA) is one of the challenging anatomies for transcatheter edge-to-edge repair (TEER) regurgitation, but relationship between baseline MVA and clinical outcomes remains unknown. This study aimed to evaluate association with procedural in patients undergoing TEER MitraClip from OCEAN-Mitral registry (Optimized Catheter Valvular Intervention-Mitral). METHODS: total 1768 were divided into 3 groups according MVA: group 1: <4.0 cm 2 , n=358; 2: 4.0–5.0...
A precision digital instantaneous heart rate meter with a wide range of 0-1023 beats/min was developed for converting the time interval between two successive beats to frequency. The resolution this device is 1 beat/min, and maximum nonlinearity error less than 0.06 percent relative full scale. Therefore, has advantages, i.e., it more precise wider other conventional tachometers.
Background: Clinical outcomes after percutaneous coronary intervention have improved with the use of drug-eluting stents, but data beyond 10 years are limited. The purpose this study was to evaluate clinical patients undergoing sirolimus-eluting stent implantation follow-up and determine impact angiographic characteristics on long-term prognosis.