A5002751767- Biomedical Ethics and Regulation
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Pharmaceutical Economics and Policy
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Cervical Cancer and HPV Research
- Ethics in medical practice
- Neuroscience and Neural Engineering
- AI in cancer detection
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Global Cancer Incidence and Screening
- Nitric Oxide and Endothelin Effects
- Global Public Health Policies and Epidemiology
- Bioinformatics and Genomic Networks
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Viral Infections and Vectors
- Biotechnology and Related Fields
- Organ Donation and Transplantation
Duke University
2021-2025
Film Independent
2013-2024
PathAI (United States)
2023-2024
Georgia State University
2024
Critical Path Institute
2023
University of Toronto
2022
Bharathidasan University
2021
Jaslok Hospital
2020
Wisconsin Institutes for Discovery
2019-2020
University of Wisconsin–Madison
2019-2020
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic in vivo discovery pipeline, we define network 222 human proteins their animal orthologs localized to BMs. Network analysis screening
Abstract The Mycobacterium tuberculosis kinase PknB is essential for growth and survival of the pathogen in vitro vivo. Here we report results our efforts to elucidate mechanism regulation activity. specific residues extracytoplasmic domain that are ligand interaction bacterium identified. interacts with mDAP-containing LipidII, this abolished upon mutation ligand-interacting residues. Abrogation ligand-binding or sequestration leads aberrant localization PknB. Contrary prevailing...
The type IV collagen triple helix, composed of three ⍺-chains, is a core basement membrane (BM) component that assembles into network within BMs. Endogenous tagging all ⍺-chains with genetically encoded fluorophores has remained elusive, limiting our understanding this crucial BM component. Through genome editing, we show the C termini C. elegans EMB-9 and LET-2 can be fused to variety create strain toolkit wild-type health. Using quantitative imaging, results suggest preference for...
Globally, individuals coinfected with the AIDS virus (HIV-1) and M. tuberculosis (causative agent of [TB]) pose major obstacles in clinical management both diseases. At heart this issue is apparent synergy between two human pathogens. On one hand, mechanisms induced by HIV-1 for reactivation TB patients are well characterized. other while findings clearly identified as a risk factor associated mortality, basic which exacerbates replication infection remain poorly The significance our...
Health monitoring is an integral part of laboratory animal quality standards. However, current or past prevalence data as well regulatory requirements dictate the frequency, type and expanse health monitoring. In effort to understand rodent pathogens in India, a preliminary study was carried out by sero-epidemiology. Sera samples obtained from 26 public private facilities were analyzed for presence antibodies against minute virus mice (MVM), ectromelia (ECTV), lymphocytic choriomeningitis...
Lipoxygenase possessing dual catalytic activities, i.e. dioxygenase and hydroperoxidase, was purified from the cytosols of term placentas non-smoking women. Concanavalin A affinity chromatography followed by phenyl-Sepharose CL-4B resulted in separation one hydrophobic non-hydrophobic isoenzyme. The concanavalin A-purified enzyme used all subsequent experiments. activity exhibited a Vmax. 204.37 +/- 17.66 nmol/min per mg protein Km 0.79 mM for linoleic acid. involvement dioxygen enzymic acid...
The key differences in cell death mechanisms the trabecular meshwork (TM) adult moderate and severe primary glaucoma remain still unanswered. This study explored glaucoma.In-vitro laboratory on surgical specimens lines.Select death-related proteins differentially expressed mass spectrometric analysis ex-vivo dissected TM patients with open-angle (POAG) or angle-closure (PACG) compared to controls (cadaver donor cornea) were validated for temporal changes gene expression in-vitro human...
Machine learning algorithms have the potential to improve patient outcomes in digital pathology. However, generalization of these tools is currently limited by sensitivity variations tissue preparation, staining procedures and scanning equipment that lead domain shift digitized slides. To overcome this limitation model generalization, we studied effectiveness two Synthetic DOmain-Targeted Augmentation (S-DOTA) methods, namely CycleGAN-enabled Scanner Transform (ST) targeted Stain Vector...
Perhaps no event in the recent past captured imagination of mainstream media as much protests against proposal to introduce reservations for other backward classes some institutions higher education (1).Although a small but active group doctors supports reservations, their views were barely covered by media.The television and print instead flooded with reports images protests.Medical students led this agitation it may be worth keeping track increasing presence medical profession political...
The Controlled Human Infection Model or CHIM, sometimes described as a human challenge study, is relatively specialised medical research technique. Researchers infect healthy participants with weakened strain of pathogen in controlled setting, order to learn more about the infection and disease, develop new vaccines for that disease. Unlike other clinical trials, where face risk harm because of, example, drug's side effects, CHIM trials are deliberately harmed through - contrary every...