The neuropeptide galanin is predominantly expressed by the lactotrophs (the prolactin secreting cell type) in rodent anterior pituitary and median eminence paraventricular nucleus of hypothalamus. Prolactin colocalize same secretory granule, expression both proteins extremely sensitive to estrogen status animal. administration estradiol-17β induces hyperplasia followed adenoma formation causes a 3,000-fold increase mRNA content lactotroph. To further study role release lactotroph growth we...

Serum concentrations of magnesium, zinc and copper were measured in postmenopausal women with osteoporosis (n = 40), osteopenia 40) or normal bone mineral density as classified on the basis T-score femur neck dual energy X-ray absorptiometry results. Mean magnesium significantly lower osteoporotic than both osteopenic women. In addition, There no statistically significant differences observed between osteopenic, control groups respect to levels. The clinical significance these changes needs...

We aimed to determine the importance of neutrophil activation and source oxidative stress in pathogenesis rheumatoid arthritis (RA) by quantification advanced oxidation protein products (AOPP) total thiol levels as markers damage, malondialdehyde (MDA) a marker lipid peroxidation myeloperoxidase (MPO) activity patients with RA. Fifty-seven were included study sub-grouped according disease (active, n = 31; inactive, 26) compared healthy controls (n 25). Serum MPO activity, AOPP, MDA, measured...

Although attention deficit and hyperactivity disorder (ADHD) are recognized as neurodevelopmental disorders characterized by impairment in executive functions, impairments social functioning often accompanied ADHD. Oxytocin (OT) has been investigated a number of psychiatric owing to its effects on interactions. The aim this study was determine the relationship between aggression, empathy OT levels children with Forty male patients ADHD, ranging age from 7 18 years, 40 healthy age-matched...

Treatment of T47-D human breast carcinoma cells with recombinant prolactin (rhPRL) induced a concentration- and time-dependent increase in the phosphotyrosine content JAK2. rhPRL also stimulated JAK2 tyrosine phosphorylation more weakly three other lines, MCF-7, ZR-75-1 MDA-MB-231. Furthermore it two isoforms transcriptional activator STAT5, STAT5a STAT5b. Surprisingly, treatment focal adhesion kinase (FAK), as determined by immunoprecipitation anti-phosphotyrosine antibody followed...

Both 17beta-estradiol and prolactin play important roles in the mammary gland, raising possibility of functional cross-talk between two signaling pathways. Here, we demonstrate that estrogen receptor-alpha (ERalpha) -beta (ERbeta) are both able to potentiate transcription from a Stat5-responsive promoter when activated by prolactin. Potentiation was observed not only presence 17beta-estradiol, but also anti-estrogens such as tamoxifen ICI 182,780. The magnitude response dependent on...

Diabetes is known to be associated with erectile dysfunction, retrograde ejaculation, level of testicular hormone, and a decrease in semen quality, respectively. In this project, we aimed investigate at the molecular level, effects NOS on testes pathology diabetes examine pentoxifylline healing. A total 50 Wistar albino male rats were divided into five groups: Group I control; II only diabetes; III IV + pentoxifylline; V pentoxifylline. received mg/kg/day during two months. comparison,...

Introduction. Ghrelin is a hormone which has effects on the secretion of growth hormone, gastrointestinal system, cardiovascular cell proliferation and reproductive system. The present study we focused relation between ghrelin GHS-R1a gene expression regulation their in testes diabetic rats. Material methods. 40 male Wistar albino rats were divided into four groups: control, sampled 4, 8 12 weeks after induction diabetes by streptozotocin (STZ) intraperitoneal injection (40 mg/kg)....

In this study, the main antioxidant enzymes (AOE) of glutathione peroxidase (GPX), superoxide dismutase (SOD), catalase (CAT) and myeloperoxidase (MPO) were identified, influence sex age in healthy human polymorphonuclear leukocytes (PMNL) was determined. The SOD, GPX, CAT MPO activities investigated intestinal parasite negative PMNL from 109 subjects aged 6 to 70 years (55 males 54 females) using simple sensitive enzyme assays. Blood cells, such as eosinophils, platelets, neutrophils,...

Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated antiproliferative effect Quercetin (QU) its combination Cisplatin (CIS) on SPC212 SPC111 cell lines. Our experiments showed that QU significantly reduced proliferation lines, altered cycle distribution, increased level Caspase 9 (C9) 3 (C3) in concentration time-dependent manner. Additionally, + CIS was found more effective when compared individual...

The aim of the study was to investigate changes serum malondialdehyde level, i.e; oxidative stress hypothesis in patients infected with Ascaris lumbricoides.Serum activity measured 43 who were positive for intestinal parasite lumbricoides. Scores obtained positives and their age-and sex-matched 60 lumbricoides negative healthy controls.The difference between levels control group statistically significant both females (P<0.05) males (P<0.05). In patient groups, no correlation found age...

To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats.To evaluate biological radiation rat tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. After sacrificing rats, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) glutathione peroxidase (GSHPx) activities malondiadehyde...

The aim of this study is to histopathalogically compare the myotoxic effects a single injection levobupivacaine, bupivacaine and ropivacaine in rat skeletal muscle.Rats received intramuscular injections 0.5% (Group B), R), levobupivacaine L), or 0.9% normal saline SF) (30 rats/group). At two, 10 20 days, rats from each group were sacrificed muscle samples examined for using hematoxylin-eosin staining under light microscope.Muscle damage Groups B, L R was similar qualitatively. In taken two...

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related mortality worldwide, driven mainly by chronic hepatitis infections and metabolic disorders, which highlights the urgent need for novel therapeutic strategies. Sirtuins, particularly SIRT1 are crucial in HCC pathogenesis, making it promising drug target. Indole‐based molecules show potential as agents interacting with key proteins like sirtuins involved cancer progression. In this study, we designed synthesized...

Attention-deficit hyperactivity disorder (ADHD) has a complex etiology and genetic, environmental biological factors are considered to play role in the of ADHD by mutually interacting. Recent studies have emphasized that inflammation may be present ADHD. This study aims investigate possible visfatin, IL-6, IL-1b TNF-α molecules ADHD.The included 60 patients 20 healthy controls between ages 6-18. Serum levels were evaluated with enzyme-linked immunosorbent assay (ELISA) kits at biochemistry...

Abstract Oxidative stress occurs when there is excessive free‐radical production or a low antioxidant level. The role of free radicals in the pathogenesis and progression many diseases has often been discussed, but it not widely investigated leishmaniasis. However, measurement oxidants antioxidants serum seems to be great value. In this study, we aimed determine lipid peroxidation levels as markers oxidative patients suffering from cutaneous leishmaniasis, which common health problem our...

The ongoing COVID-19 pandemic poses a significant threat to human health. Many hypotheses regarding pathogenesis have been proposed and are being tried be clarified by experimental clinical studies. This study aimed reveal the roles of innate immune system modulator GAS6/sAXL pathway, endothelial dysfunction markers vascular growth factor (VEGF) hypoxia-inducible (HIF)-1α, antiviral effective TRIM25 TRIM56 proteins in COVID-19. included 55 patients with 25 healthy individuals. serum levels...

Abstract A quantitative elemental analysis of scalp hair female breast cancer patients (n = 26) and controls 27) was used to study find out correlation possible changes, between healthy controls. Atomic absorption spectrophotometer the method determine copper, magnesium, zinc levels. There were no differences in magnesium concentrations ( P &gt; 0.05) subjects. However, comparison mean contents with showed a significant enhancement copper &lt; but declining trends for patients. The...

In the present study, we tried to investigate whether infection with cystic echinococcosis provokes oxidative stress in host by measuring changes plasma levels of anti-oxidants enzymes. 23 patients and 25 control individuals were included study. Plasma superoxide dismutase [Cu–Zn dismutases, cytoplasmic form/superoxide 1] glutathione peroxidase [Cytoplasmic gluthatione activities nitrite all determined based on colorimetric methods. Statistically significant decreased nitric oxide...