A5103025344- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Reproductive tract infections research
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Adolescent Sexual and Reproductive Health
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Long-Term Effects of COVID-19
- Syphilis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Pelvic floor disorders treatments
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Advanced X-ray and CT Imaging
- COVID-19 Clinical Research Studies
- Cardiovascular Issues in Pregnancy
- Acute Myocardial Infarction Research
- Optical Imaging and Spectroscopy Techniques
- COVID-19 and healthcare impacts
- Vascular Anomalies and Treatments
- Biomarkers in Disease Mechanisms
- Congenital Heart Disease Studies
University of Leicester
2024
University College London
2023-2024
University College Hospital
2024
National Hospital for Neurology and Neurosurgery
2023-2024
Royal Brompton & Harefield NHS Foundation Trust
2019-2023
Harefield Hospital
2020-2023
National Health Service
2023
Leeds Teaching Hospitals NHS Trust
2023
Royal Brompton Hospital
2018-2022
University Hospital Galway
2013
Epicardial adipose tissue (EAT) volume is a marker of visceral obesity that can be measured in coronary computed tomography angiograms (CCTA). The clinical value integrating this measurement routine CCTA interpretation has not been documented.
OBJECTIVES: Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients severe on ICU, or without extracorporeal membrane oxygenation. DESIGN: undertook a single-center, retrospective analysis 72 2019-associated acute respiratory distress syndrome admitted to ICU. CT angiography thorax, abdomen, pelvis were performed at admission as per routine institution...
The role of dual energy computed tomographic pulmonary angiography (DECTPA) in revealing vasculopathy coronavirus disease 2019 (COVID-19) has not been fully explored.To evaluate the relationship between DECTPA and duration, right ventricular dysfunction (RVD), lung compliance, D-dimer obstruction index COVID-19 pneumonia.This institutional review board approved this retrospective study, waived informed consent requirement. Between March-May 2020, 27 consecutive ventilated patients with...
Spontaneous coronary artery dissection (SCAD) has been associated with fibromuscular dysplasia (FMD) and other extracoronary arterial abnormalities. However, the prevalence, severity, clinical relevance of these abnormalities remain unclear.To assess prevalence spectrum FMD in patients SCAD vs controls.This case series included 173 angiographically confirmed enrolled between January 1, 2015, December 31, 2019. Imaging beds was performed by magnetic resonance angiography (MRA). Forty-one...
Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) offers the potential to noninvasively characterize phenotypic substrate for sudden death (SCD).
Background: Partial anomalous venous connections (PAPVC) are associated with left to right shunting and heart dilatation. Identification of PAPVC has increased widespread use cross-sectional imaging modalities. However, management strategies mostly based on expert opinion given the scarcity data from large series. We aimed define types significance isolated atrial septal defect (ASD) detected by cardiovascular magnetic resonance. Methods: retrospectively reviewed our resonance database 2002...
Deoxycholic acid (DCA) is a secondary bile that modulates signalling pathways in epithelial cells. DCA has been implicated pathogenesis of colon carcinoma, particularly by activation the protein kinase C (PKC) pathway. Ursodeoxycholic (UDCA), tertiary acid, observed to have chemopreventative effects. The aim this study was investigate effect and UDCA on subcellular localization activity PKCη its downstream effects Golgi structure cancer cell model. expression localized HCT116 induced...
A number of females with pelvic inflammatory disease will present to general surgical services non-specific abdominal pain. Screening for sexually transmitted infections (STI) as an underlying cause is not routinely offered. We therefore established STI screening programme young presenting a same day emergency ambulatory clinic part the diagnostic pathway. Data outlining incidence and prevalence STIs lower pain were collected.
Complication rates of paravalvular aortic regurgitation (PVR) and permanent pacemaker insertion remain high in patients undergoing trans-catheter valve for severe stenosis. The spatial distribution calcium between individual leaflets, its potential role these complications is gaining interest. We aimed to assess the accuracy leaflet quantification, determine effect on frequency complications.This was a retrospective study 251 who underwent using Evolut RTM valve. off-line Terarecon software...
In situ pulmonary arterial thrombosis in COVID-19 is not visible on CTPA. However, the presence of CT-measured right heart and artery dilatation likely attributable to this process may be a possible surrogate for its detection. https://bit.ly/3g7z5TV.
A patient in her 60s presented to a district general hospital with headache, loss of consciousness, and vomiting. She was diagnosed subarachnoid haemorrhage secondary an anterior communicating artery aneurysm transferred tertiary unit for coiling the under neurosurgical team. intubated had close observational monitoring, where it noted that oxygen saturations, obtained using finger-pulse oximetry, varied between 94% 100%. Each fingernail different acrylic nail polish colour which we believe...
Abstract Background Prospective studies harnessing late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) afford the potential to non-invasively characterise phenotypic substrate for sudden cardiac death (SCD) and simultaneously interrogate its mechanistic drivers. Purpose To assess utility of infarct characterisation by CMR, including scar microstructure analysis, predict SCD in prospectively investigated patients with coronary heart disease (CHD). Methods Patients stable...
•Critical aortic stenosis can cause severe biventricular disease.•Painless jaundice present secondary to failure.•TAVR treats high-risk critical stenosis.•TAVR reverse clinical and biochemical congestive hepatopathy.•High-risk TAVR be performed using circulatory support.
Abstract Aims Methods Women aged 18-44 years presenting to ASC were offered a voluntary self-collected high vulvovaginal swab for chlamydia and gonorrhoea at triage. Data was collected over one year (Dec 2021-Dec 2022). Testing 299 patients, 20 declined participate 18 samples rejected. Positive results referred the Sexual Health service treatment contact tracing as agreed on pre-planned referral pathway. Results 5.4% of swabs positive (2 Gonorrhoea 12 Chlamydia). The mean age those testing...
Abstract Aims To establish a sexually transmitted infection (STI) screening programme for females presenting to an Emergency Ambulatory Surgical Clinic (ASC), and analyse incidence prevalence of STIs as underlying cause their abdominal pain. Methods Observational cohort study in ASC tertiary hospital. Between December 2021 2022, aged 18-44 years with pain were offered self-collected vulvovaginal swabs chlamydia gonorrhoea part new standardised diagnostic pathway. Positive results referred...
A 53-year-old female with dyspnoea and atypical chest pain. Her electrocardiogram demonstrated a left bundle branch block, transthoracic echocardiogram mildly impaired ventricle ejection fraction, coronary angiogram revealed unobstructed arteries. She was referred for cardiovascular magnetic resonance (CMR) structural functional assessment. imaging an unexpected finding of off-resonance artefact within the wall. This material secondary to ferromagnetic material.Chest X ray computer...