A5045537694- Hepatocellular Carcinoma Treatment and Prognosis
- Fibroblast Growth Factor Research
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
Swiss Cancer Center Léman
2023-2024
University of Lausanne
2022-2024
SIB Swiss Institute of Bioinformatics
2023
Politecnico di Milano
2020
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs disease outcome, we focused on tumor-to-tumor variation to examine 52 head neck squamous cell carcinomas. We found macrophage polarity-defined by
ABSTRACT Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses tissue challenged by scale diversity data. Here we present CellCharter, an algorithmic framework to identify, characterize, compare niches spatially resolved datasets. CellCharter outperformed existing approaches effectively identified across datasets generated different technologies, comprising hundreds samples...
Abstract Motivation The relationship between gene co-expression and chromatin conformation is of great biological interest. Thanks to high-throughput chromosome capture technologies (Hi-C), researchers are gaining insights on the tri-dimensional organization genome. Given high complexity Hi-C data difficult definition networks, development proper computational tools investigate such rapidly interest researchers. One most fascinating questions in this context how topology correlates with...
Abstract Cancer cell plasticity underlies the progression of several solid tumors. In lung adenocarcinoma, morphological changes characterizing transition from indolent to aggressive disease exhibit profound epigenetic and transcriptional reprogramming1. However, extent, features, drivers cancer in human adenocarcinoma is still largely unexplored. Here, we assembled analyzed a meta-cohort 119 tumors by single-cell RNA-sequencing, for total ~730,000 cells. heterogeneity was result...
The efficacy of anti-cancer therapies depends on the genomic composition tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B cell lymphomas are a heterogeneous group tumors emerging from cells at different stages differentiation exhibiting tumor-specific interactions with tumor microenvironment. Thus, to measure response therapy in lymphoma, it is critical preserve functional among immune cells. Here, we developed platform maintain small fragments human...
The efficacy of anti-cancer therapies depends on the genomic composition tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group tumors emerging from B-cells at different stages differentiation exhibiting tumor-specific interactions with tumor microenvironment. Thus, effect drug treatments can be influenced by functional among immune cells. Here, we develop platform to maintain small fragments human lymphoma tissue in...
The concept of precision medicine emerged to match targeted therapies with the genomic fingerprint each cancer patient. However, cellular composition and architecture tumor tissues are additional parameters that influence response therapies. B-cell lymphomas a heterogenous group tumors emerging from B cells in different stages differentiation specialized areas lymph nodes. Therefore, order reliably anticipate responses treatment, lymphoma models must preserve spatial organization functional...