A5075762636- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Thyroid Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Lymphatic System and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Oral Health Pathology and Treatment
- Airway Management and Intubation Techniques
- Ear and Head Tumors
- Foreign Body Medical Cases
- Infectious Diseases and Mycology
- Histiocytic Disorders and Treatments
- Parvovirus B19 Infection Studies
- Wnt/β-catenin signaling in development and cancer
- Respiratory and Cough-Related Research
- Voice and Speech Disorders
- Circular RNAs in diseases
- Cardiovascular and Diving-Related Complications
- Glaucoma and retinal disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- FOXO transcription factor regulation
- Facial Nerve Paralysis Treatment and Research
- Traumatic Ocular and Foreign Body Injuries
University Hospital of Geneva
2020-2025
Hôpital Beau-Séjour
2022
University of Lausanne
2014-2020
University Hospital of Lausanne
2014-2018
Centre de Chirurgie Plastique
2015
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs disease outcome, we focused on tumor-to-tumor variation to examine 52 head neck squamous cell carcinomas. We found macrophage polarity-defined by
Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with dismal prognosis. Improving this outcome requires better understanding of cancer populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in surgical model barcoded HNSCC growing the submental region immunodeficient mice. Clonal substitution massive reduction heterogeneity emerged as hallmarks local recurrence, clones...
HPV‐positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management particularly debated in the case of postsurgical high‐risk features, that is, positive surgical margins extracapsular spread (ECS). In this complex emerging framework HNSCC treatment, representative preclinical models are needed to support future clinical trials advances personalized medicine. Here, we present an immunocompetent mouse model based on implantation tonsil epithelial...
Abstract Background There have been few recent advances in the identification of occult lymph node metastases (OLNM) oral squamous cell carcinoma (OSCC). This study aimed to develop, compare, and validate several machine learning models predict OLNM clinically N0 (cN0) OSCC. Methods The biomarkers CD31 PROX1 were combined with relevant histological parameters evaluated on a training cohort (n = 56) using four different state‐of‐the‐art models. Next, optimized tested an external validation...
Abstract Background The correlation between podoplanin expression and extracapsular spread in head neck squamous cell carcinoma (HNSCC) has never been reported. purpose of this study was to assess the predictive value for parameter. Methods Subjective immunoreactivity scores semiquantitative image analysis were performed 67 patients with primary oral their corresponding lymph nodes. Neck classification showed 34 cases (51%) pN0 33 (49%) pN+. Correlation levels histopathological data...
INTRODUCTION: Chronic subjective dizziness (CSD) is frequently encountered in neurotology clinics.This diagnosis mainly clinical, but computerized dynamic posturography (CDP) could be a helpful instrumental tool the identification of these patients and validation treatment.This study was aimed to look for specific posturographic pattern among diagnosed with CSD, eventually visualize improvement after vestibular rehabilitation. METHODS:Single center, retrospective review from 2009 2014.We...
Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter controversy for decades. vascular density within the tumor microenvironment, as an indicator ongoing angiogenesis, could constitute attractive predictor LNM. use panvascular endothelial antibody CD31 marker LNM never reported. aim this study was to assess predictive value microvascular detection oral cavity oropharynx. Study Design Case series with chart review. Setting...
Abstract Sustained expression of FOXM1 is a hallmark nearly all human cancers including squamous cell carcinomas the head and neck (HNSCC). HNSCCs partially preserve epithelial differentiation program, which recapitulates fetal adult traits tissue tumor origin but deregulated by genetic alterations tumor‐supporting pathways. Using shRNA‐mediated knockdown, we demonstrate minimal impact on proliferation migration HNSCC lines under standard culture conditions. However, knockdown in...
A 44-year-old man was referred for treatment of symptomatic sialolithiasis in the right Wharton duct. Intraoral removal could not be performed because bilateral swellings on lingual surface mandible. The patient unable to recall when he first became aware lesions. He had no
Objective . This paper describes a patient with left hemifacial pain elicited by the use of CPAP mask. Case Report A 74-year-old man was referred history in maxillary sinus related to his interface, thereby prohibiting latter. Computed tomography revealed an intra-sinusal ectopic third molar floor corresponding painful area. After removal tooth under local anesthesia Caldwell-Luc approach, relieved symptoms. Conclusion Although is rare, this case points out importance actively looking for...
Abstract Background The use of lymphatic vessel density as a predictor occult lymph node metastasis (OLNM) in head and neck squamous cell carcinoma (HNSCC) has never been reported. Methods Staining the specific endothelial cells nuclear marker, PROX1, an indicator was determined by counting number positive carcinomas (SCCs) oral cavity oropharynx with clinically negative necks. Correlation histopathological data established. Results Peritumoral PROX1 count significantly correlated detection...
Isolated fractures of the zygomatic arch represent 5% to 14% all complex fractures. Bilateral isolated fractures, which are defined as both arches without any other facial fracture, extremely rare. In this case report, we present a rare fracture pattern.
Rosai-Dorfman disease is a non-Langherans cell histiocytosis typically revealed by lymphadenopathy. Extranodal involvement occurs in 43% and most commonly involves the head neck, skin, bones. Few reports have described laryngeal lesions. We report case of 27-year-old female, presenting as an obstructing transglottic mass. provide results MRI PET-scanner examination. As treatment relies on surgical excision diagnosis depends pathological examination, we also detail analysis that followed...
Anomalies of the larynx and trachea can cause respiratory distress in infants older children. Depending on its nature, degree extent disease invasive open surgery is indicated. Non-airway-related co-morbidities increase challenges treatment. Neurological deficit poses a great challenge as it associated with hypotonia causes diminished laryngeal coordination. The definition success treatment laryngotracheal has always focused post-operative functional outcomes: breathing, voice swallowing....