A5046045054- Atherosclerosis and Cardiovascular Diseases
- Genomics, phytochemicals, and oxidative stress
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Anomalies and Fetal Surgery
- Immune cells in cancer
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Glutathione Transferases and Polymorphisms
- Amoebic Infections and Treatments
- Free Radicals and Antioxidants
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Inflammasome and immune disorders
- Sodium Intake and Health
- Antioxidant Activity and Oxidative Stress
- Heat shock proteins research
- Cardiovascular Health and Risk Factors
Istituto Superiore di Sanità
2015-2025
Sapienza University of Rome
2014
San Gallicano Hospital
2003
Abstract Objective To investigate the association of β 2 ‐glycoprotein I (β GPI) with lipid rafts in monocytic cells and to evaluate proinflammatory procoagulant effects anti‐β GPI binding its target antigen on monocyte plasma membrane. Methods Human monocytes were fractionated by sucrose density‐gradient centrifugation analyzed Western blotting. Immunoprecipitation experiments performed analyze possible interaction annexin A2 Toll‐like receptor 4 (TLR‐4). Monocytes then stimulated...
ABSTRACT Despite inducing a strong host cellular and humoral immune response, the helminth Echinococcus granulosus is highly successful parasite that develops, progresses, ultimately causes chronic disease. Although surgery remains preferred therapeutic option, pharmacological research now envisages antihelminthic strategies. To understand mechanisms E. uses to escape immunosurveillance promote infection, we investigated how two hydatid cyst components, purified antigen B (AgB) sheep fluid...
Abstract Phenothiazines (PTZs) are an emerging group of molecules showing effectiveness toward redox signaling and reduction oxidative injury to cells, via the activation on Kelch‐like ECH‐associated protein 1/nuclear factor erythroid 2‐related 2 (Nrf2). Although several electrophilic indirect Nrf2 activators have been reported, risk “off‐target” effect due complexity their molecular mechanisms action, has aroused research interest non‐electrophilic direct modulators pathway, such as PTZs....
ABSTRACT By directly suppressing the function of certain immune cell subsets and by stimulating other populations related to immunopathology, parasite-derived substances play an important role in chronic establishment parasitic disease. Our objective was twofold: (i) investigate further Echinococcus granulosus antigen B (AgB) human early inflammatory response determining its effect on polymorphonuclear (PMN) random migration, chemotaxis, oxidative metabolism (ii) determine action acquired...
Macrophages consist of two main subsets: the proinflammatory M1 subset and anti-inflammatory M2 one. 7-oxo-cholesterol, most abundant cholesterol autoxidation product within atherosclerotic plaque, is able to skew M1/M2 balance towards a profile. In present study, we explored ability polyphenolic compound resveratrol counteract 7-oxo-cholesterol-triggered signaling in macrophages. Resveratrol-pretreated human monocyte-derived macrophages were challenged with 7-oxo-cholesterol analyzed for...
Background: Tobacco consumption, incorrect nutrition and insufficient physical activity/sedentariness represent modifiable NCDs risk factors in Western countries. To evaluate recent lifestyle indicators Italy, data from the national Health Examination Survey (HES), implemented 2018–2019 within CUORE Project, were assessed. Methods: Age–sex standardized results random samples of Italian general population (35–74 years) reported by sex, age-class, educational level geographical area. From 2106...
Oxidative stress is characterized by the deregulation of redox state in cells, which plays a role initiation various types cancers. The activity galectin-1 (Gal-1) depends on cell and microenvironment. Gal-1 expression has been related to many different tumor types, as it important roles several processes involved cancer progression, such apoptosis, migration, adhesion, immune response. erythroid-2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway crucial...
To evaluate the diagnostic sensitivity and specificity of immunoelectrophoresis (IEP), indirect haemagglutination (IHA), enzyme-linked immunosorbent assay (ELISA) immunoblotting (IB), we compared their ability in detecting IgG antibodies to a hydatid fluid fraction (HFF) native recombinant antigen B Echinococcus granulosus. We tested sera from patients who had cystic echinococcosis (CE) grouped according type cysts (n = 204), with other parasitic diseases 21), lung or liver carcinomas 6)...
Objective— Systemic Lupus Erythematosus (SLE) and antiphospholipid syndrome (APS) are associated with a high prevalence of atherosclerosis. β2 glycoprotein I (β2GPI) represents link between autoimmunity endothelial dysfunction. Recently, β2GPI reactive T cells have been identified; however, their role in atherosclerosis is still under investigation. We evaluated early patients SLE APS investigated cell reactivity to its relationship atherosclerotic process. Approach Results— Fifty SLE, 18...
Neuropeptide Y (NPY), a major autonomic nervous system and stress mediator, is emerging as an important regulator of inflammation, implicated in autoimmunity, asthma, atherosclerosis, cancer. Yet the role NPY regulating phenotype functions dendritic cells (DCs), professional antigen-presenting cells, remains undefined. Here we investigated whether could induce DCs to migrate, mature, polarize naive T lymphocytes. We found that induced dose-dependent migration human monocyte-derived immature...