A5078445304- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Bipolar Disorder and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Structural Integrity and Reliability Analysis
- Fatigue and fracture mechanics
- Sleep and related disorders
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Health and Well-being Studies
- Hepatitis B Virus Studies
- Material Properties and Failure Mechanisms
- Neonatal Respiratory Health Research
- Law, AI, and Intellectual Property
- CAR-T cell therapy research
- Diabetes Treatment and Management
- Complement system in diseases
- Mesenchymal stem cell research
- Glycogen Storage Diseases and Myoclonus
- Drilling and Well Engineering
- Cardiac Health and Mental Health
Erasmus MC
2017-2025
Sorbonne Université
2025
Assistance Publique – Hôpitaux de Paris
2025
Centre de Recherche des Cordeliers
2025
Inserm
2025
Merus (Netherlands)
2022
University Hospital and Clinics
2021
University Medical Center
2021
Hôpital Sahloul
2009-2020
Erasmus University Rotterdam
2020
Mesenchymal stromal cells (MSC) are a promising therapy for immunological disorders. However, culture expanded MSC large and get trapped in the capillary networks of lungs after intravenous infusion, where they have short survival time. Hypothetically, living risk tumor formation. To reduce risks associated with infusion improve distribution body, we generated membrane particles (MP) stimulated IFN-γ (MPγ). Tracking analysis electron microscopy indicated that average size MP was 120 nm,...
Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells (DC) to treat chronic infections or cancer. Currently, the design of SLPs relies on in silico prediction and multifactorial T assays determine which best cross-presented DC human leukocyte antigen class I (HLA-I). Furthermore, it is unknown how TLR ligand-based adjuvants affect cross-presentation. Here, we generated unique, high-quality immunopeptidome dataset DCs pulsed with 12 hepatitis B virus...
Antigen-specific immunotherapy is a promising strategy to treat HBV infection and hepatocellular carcinoma (HCC). To facilitate killing of malignant and/or infected hepatocytes, it vital know which T cell targets are presented by human leucocyte antigen (HLA)-I complexes on patient-derived hepatocytes. Here, we aimed reveal the hepatocyte-specific HLA-I peptidome with emphasis peptides derived from proteins tumour-associated antigens (TAA) guide development antigen-specific...
Therapeutic vaccination based on synthetic long peptides (SLP®) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV).We designed SLPs three HBV proteins, HBcAg the non-secreted proteins polymerase X, investigated their ability to induce responses ex vivo. A set of 17 was constructed viral protein conservation, functionality, predicted validated binders prevalent human leukocyte antigen (HLA) supertypes, HLA I epitopes,...
<title>Abstract</title> Synthetic long peptides (SLPs) are a promising vaccine modality that exploit dendritic cells (DC) to treat chronic infections or cancer. Currently, the design of SLPs relies on in silico prediction and multifactorial T assays determine which best cross-presented DC human leukocyte antigen class I (HLA-I). Furthermore, it is unknown how TLR ligand-based adjuvants affect cross-presentation. Here, we generated unique, high-quality immunopeptidome dataset DCs pulsed with...
Terminal T-cell exhaustion poses a significant barrier to effective anticancer immunotherapy efficacy, with current drugs aimed at reversing being limited. Recent investigations into the molecular drivers of have led identification chronic IL2 receptor (IL2R)-STAT5 pathway signaling in mediating exhaustion. We targeted key downstream IL2R-intermediate JAK 3 using clinically relevant highly specific JAK3-inhibitor (JAK3i; PF-06651600) that potently inhibited STAT5-phosphorylation vitro....
Immunopeptidomics is used to identify novel epitopes for (therapeutic) vaccination strategies in cancer and infectious disease. Various false discovery rates (FDRs) are applied the field when converting liquid chromatography-tandem mass spectrometry (LC-MS/MS) spectra peptides. Subsequently, large efforts have recently been made rescue peptides of lower confidence. However, it remains unclear what overall relation between FDR threshold percentage obtained HLA-binders. We here directly...
Introduction Sleep disturbances and suicidal behaviors are common among patients with type II bipolar disorder ( BDII), but the relationship between two is unclear. Investigating this connection important to identify interventions that can improve quality of life reduce risk suicide in population. Objectives Our study’s objective examine association sleep disorders behavior (BDII). Methods In order comprehensively investigate individuals diagnosed (TBII), we conducted a cross-sectional,...
Introduction Sleep disruptions are frequently observed in individuals with bipolar disorder and have been linked to various unfavorable consequences, such as an elevated risk of relapse lower quality life. Nonetheless, the impact sociodemographic factors on development progression these remains largely unexplored. Gaining insight into relationship between sleep is essential for designing effective interventions enhancing clinical outcomes affected by Objectives The objective this study...
The Burnout or the professional exhaustion syndrome is common among doctors, especially primary care practitioners. rates range from 25 to 76% according specialties. Aims: Main objective was assess prevalence of burnout in Tunisian practitioners working public sector region Cap Bon. Secondary objectives were determine risk factors and consequences associated with this syndrome. Methods: transversal study using four scales: Anonymous auto questionnaire elaborated by medical team, Maslach...
Several factors affect the behaviour of pipelines constructed by butt welding big diameter tubes. The heterogeneous properties tubes' metal and weld de-fect working capacity once put into service. recourse to a reliability approach, during projection makes it possible, on one hand measure risk incurred, association pipe-line fracture probability safety factor other this allows avoid its over sizing or estimate under risk. Thus, in context, formulation forward present work reason...
<h3>Background</h3> Costimulatory molecules, such as CD137 (4-1BB), have emerged promising targets for cancer immunotherapy. Despite results in animal tumor models, clinical trials with agonists had limited success due to both dependency on FcgR-mediated clustering and dose limiting hepatotoxicity. Merus has developed an Fc-silenced Biclonics<sup>®</sup> CD137×PD-L1 antibody, MCLA-145, whose stimulatory activity is correlated PD-L1-mediated which designed be preferentially confined the PD-L1...
Supplementary Figure from Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy
Supplementary Figure from Low-Dose JAK3 Inhibition Improves Antitumor T-Cell Immunity and Immunotherapy Efficacy
<div>Abstract<p>Terminal T-cell exhaustion poses a significant barrier to effective anticancer immunotherapy efficacy, with current drugs aimed at reversing being limited. Recent investigations into the molecular drivers of have led identification chronic IL2 receptor (IL2R)–STAT5 pathway signaling in mediating exhaustion. We targeted key downstream IL2R-intermediate JAK 3 using clinically relevant highly specific JAK3-inhibitor (JAK3i; PF-06651600) that potently inhibited...
<div>Abstract<p>Terminal T-cell exhaustion poses a significant barrier to effective anticancer immunotherapy efficacy, with current drugs aimed at reversing being limited. Recent investigations into the molecular drivers of have led identification chronic IL2 receptor (IL2R)–STAT5 pathway signaling in mediating exhaustion. We targeted key downstream IL2R-intermediate JAK 3 using clinically relevant highly specific JAK3-inhibitor (JAK3i; PF-06651600) that potently inhibited...
Introduction Depression is commonbut still ignored in general practice whereas it a source of handicap, psychiatric and somatic morbidity. Aims To assess the punctual prevalence major depression primary healthcare centers Tunisia. Methods A Transversal study during march 2007 was conducted three Hammamet city. All partients having sixteen years or older were evaluated by Cluster Mini International Neuropsychiatric Interview (MINI). Patients meeting criteria for depressive disorder had...
Introduction Les patients présentant une épilepsie ont un risque accru de survenue symptômes psychotiques et notamment schizophrénie. Le rapport étiopathogénique entre ces deux pathologies reste mal élucidé. Objectif Analyser à travers observation clinique en fonction des données la littérature le lien Méthodes Dans ce travail, nous avons rapporté cas d’un patient suivi pour schizophrénie atteint d’épilepsie. Résultats M. F., âgé 38 ans, aux antécédents convulsions fébriles l’âge 2 est...
Engineering controlled terms: Hydrocarbons; Repair Economic approach; Growing demand; Supply reliability; Technical analysis; Transporting pipelines Engineering main heading: Economic analysis