A5059532306- Complement system in diseases
- Blood groups and transfusion
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Nerve injury and regeneration
- Lung Cancer Treatments and Mutations
- Bacterial Identification and Susceptibility Testing
- Renal Diseases and Glomerulopathies
- Gastrointestinal Tumor Research and Treatment
- Chronic Myeloid Leukemia Treatments
- Digital Imaging for Blood Diseases
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Veterinary Orthopedics and Neurology
- Neurogenetic and Muscular Disorders Research
- Renal Transplantation Outcomes and Treatments
- Tumors and Oncological Cases
- Abdominal Trauma and Injuries
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
- Amyotrophic Lateral Sclerosis Research
Hospital Erasto Gaertner
2019-2025
Gaertner (United States)
2022-2024
Universidade Federal do Paraná
2014-2023
Hospital de Santa Maria
2018
Universidad Maimónides
2012
Uncontrolled activation of the innate immune system promotes deterioration neurons in different neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). T-cell vaccination (TCV) was developed by Irun Cohen and coworkers at Weizmann Institute Science (Israel) during late 1970s has been demonstrated to be an effective treatment for human autoimmune diseases a regulator macrophage animal models. We treated seven ALS patients with this cell therapy were able slow or stop...
Abstract The complete blood count (CBC) is one of the most requested tests by physicians. CBC tests, realized in conventional hematological analyzers, are restricted to centralized laboratories due frequent maintenance, large devices, and expensive costs required. On other hand, handheld devices commercially available show high prices not liable calibration or control procedures, which results poor quality compared standard hematology instruments. Hilab system a small-handed platform that...
Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions the central nervous system (CNS) and orbits, very few case reports small series have expanded their pathological characterization. We sought to describe a cases of SFT from single laboratory neuropathology belonging tertiary university hospital.Retrospective histopathological description eight CNS orbital over 21-year period time.Median age was 47.3 years four were males. Clinical...
The development of the Brazilian Registry Hematopoietic Cell Transplantation in collaboration with Center for International Blood and Marrow Transplant Research (CIBMTR) allowed an assessment activity general outcomes transplants Brazil. Here, we report updated activity. transplant centers their data to CIBMTR, using FormsNet3 platform. Information returns Cellular Therapy Bone Society (SBTMO) through Data Back Centers (DBtC) tool. from patients who received HCT 2012 2023 were extracted...
The complete blood count (CBC) is a highly requested test that generally restricted to centralized laboratories, which are limited by high cost, being maintenance-demanding, and requiring costly equipment. Hilab System (HS) small, handheld hematological platform uses microscopy chromatography techniques, combined with machine learning (ML) artificial intelligence (AI), perform CBC test. This ML AI techniques add higher accuracy reliability the results besides allowing for faster reporting....
Chronic myeloid leukemia (CML) is a well-characterized oncological disease in which virtually all patients possess translocation (9;22) that generates the tyrosine kinase BCR::ABL1 protein. This represents one of milestones molecular oncology terms both diagnostic and prognostic evaluations. The detection transcription required factor for CML diagnosis, its quantification essential assessing treatment options clinical approaches. In context, point mutations on ABL1 gene are also challenge...
The first hematopoietic stem cell transplantation (HSCT) program in Latin America started 1979 at the federal university hospital Curitiba, Paraná, Brazil. Over years, number of centers performing transplants our country has increased tremendously, generating need to know results this treatment modality. Understanding HSCT scenario Brazil is still challenging, since not all Brazilian report data Center for International Blood and Marrow Research (CIBMTR). Despite improvement reporting over...
Resumo A síndrome hemolítico-urêmica atípica (SHUa) é uma doença grave, pouco prevalente, com acometimento em qualquer idade e apresentação esporádica ou familiar. SHUa causada por ativação descontrolada do sistema complemento. plasmaférese foi o tratamento padronizado anos, resultados desfavoráveis, levando à renal crônica terminal morte aproximadamente 40% dos pacientes durante as primeiras manifestações clínicas. O Eculizumab um anticorpo monoclonal humanizado contra componente C5...
The first HSCT program in Latin America started 1979 at the Federal University Hospital (Curitiba, Paraná). Over years, number of centers performing transplants country increased, generating need to know results this modality treatment. Understanding scenario Brazil is still challenging since not all Brazilian report data Center for International Blood and Marrow Research (CIBMTR). Although it has been improving over last infrastructure trained managers are lacking. partnership between...
Chronic myeloid leukemia (CML) is a type of whose main genetic marker the reciprocal translocation that leads to production BCR::ABL1 oncoprotein. The expression some genes may interfere with progression and development leukemias. MicroRNAs are small non-coding RNAs have potential alter be correlated types could used as biomarkers in diagnosis prognosis patients. Therefore, this project carried out an analysis microRNA-type plasma patients chronic at unique points, including follow-up from...
Infection caused by the human papillomavirus (HPV) is common among sexually active population worldwide. With 200 known genotypes, 15 of them are considered high-risk oncogenic, with types 16 and 18 being most associated anogenital head/neck cancers. The cell cycle, consisting G1, S, G2, M phases, regulated tumor suppressor genes such as Rb p53, whose dysregulation can result in continuous replication damaged cells. High-risk HPVs related to neoplasias, immune response typically eliminates...
Introduction: Pembrolizumab (pembro) was originally approved by the FDA for treatment of R/R cHL and PMBCL at 200 mg every 3 weeks (Q3W). Recently, granted accelerated approval pembro 400 Q6W in all indications based on data from solid tumors. The open-label, single-arm, phase 2 KEYNOTE-B68 study (NCT04875195) is evaluating efficacy safety patients (pts) with or PMBCL. Results after 9 months follow-up are presented. Methods: Pts were ≥18 y old, had histologically confirmed PMBCL, measurable...
Abstract The complete blood count (CBC) is one of the most requested tests by physicians. Mostly realized in conventional hematological analyzers, CBC are restricted to centralized laboratories, due frequent maintenance, size devices, and expensive costs that these analyzers require. On other hand, handheld devices commercially available present high not liable calibration or control procedures, which results poor quality compared standard hematology instruments. Hilab system a small-handed...
O tratamento de escolha para a púrpura trombocitopênica trombótica, um transtorno na agregação plaquetária com hemólise desordenada e oclusão microvasculatura, consiste em plasmaférese uso corticosteroides. No entanto, há casos refratários essa terapêutica, o Rituximab, anticorpo monoclonal anti-CD20, parece ser uma alternativa. Relatamos caso paciente 35 anos, quadro sangramento comprometimento neurológico, que foi submetida evoluiu instabilidade hemodinâmica. Após tentativa sem sucesso...
In spite of modern antimicrobial and supportive therapy, bacterial fungal infections are still major complications in patients with profound neutropenia. For decades, the value granulocyte transfusion (GTX) has been explored results not conclusive. Neutropenia caused by transplant conditioning regimens who fail to respond agents is one most common indications for GTX. The purpose this study was analyze outcomes risk factors survival received a retrospective analysis performed on all...