A5041868692- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Fuel Cells and Related Materials
- Metabolism and Genetic Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutrition and Health in Aging
- European and International Law Studies
- Diabetes Treatment and Management
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Pancreatic function and diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Marine Toxins and Detection Methods
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- Cardiovascular and exercise physiology
- Parathyroid Disorders and Treatments
Aarhus University
2020-2025
Aarhus University Hospital
2020-2025
Background The heart can metabolize the microbiota‐derived short‐chain fatty acid butyrate. Butyrate may have beneficial effects in failure, but underlying mechanisms are unknown. We tested hypothesis that butyrate elevates cardiac output by involving direct stimulation of contractility and vasorelaxation rats. Methods Results examined on (1) vivo hemodynamics using parallel echocardiographic invasive blood pressure measurements, (2) isolated perfused hearts Langendorff systems under...
Background Pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary (CTEPH) are debilitating diseases with a high mortality. Despite emerging treatments, vascular resistance frequently remains elevated. However, the ketone body 3-hydroxybutyrate (3-OHB) may reduce in these patients. Hence, aim was to assess hemodynamic effects of 3-OHB patients PAH CTEPH. Methods and Results We enrolled (n=10) CTEPH residual hypertension. They received infusion placebo (saline) for 2 hours...
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the cardiovascular sites of action remain obscure. Here, we test hypothesis rats that 3-OHB acts directly on heart to increase contractility vessels lower systemic vascular resistance. We investigate effects (a) vivo hemodynamics using echocardiography invasive measurements, (b) isolated perfused hearts Langendorff systems, (c) arteries veins isometric...
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) by 35% to 40% in healthy people and with heart failure. mechanisms underlying the effects of 3-OHB on myocardial contractility loading conditions as well cardiovascular its enantiomeric forms, D-3-OHB L-3-OHB, remain undetermined.
Abstract Normothermic regional perfusion (NRP) allows assessment of therapeutic interventions prior to donation after circulatory death transplantation. Sodium-3-hydroxybutyrate (3-OHB) increases cardiac output in heart failure patients and diminishes ischemia–reperfusion injury, presumably by improving mitochondrial metabolism. We investigated effects 3-OHB on function transplanted hearts organoids. Donor pigs (n = 14) underwent followed NRP. Following static cold storage, were into...
H+ facilitates metabolic blood flow regulation while negatively impacting cardiac contractility. Cardiovascular consequences of conjugate bases accumulating alongside remain unclear. Here, we evaluate the cardiovascular effects nine prominent carboxylates-particularly lactate, 3-hydroxybutyrate, and butyrate-linked to microbial activity. Comparing actions pH-adjusted Na-carboxylates equiosmolar NaCl, study arteries veins isolated from healthy rats humans with ischaemic heart disease,...
The Sodium Glucose Co-Transporter-2 inhibitor, empagliflozin (EMPA), reduces mortality and hospitalisation for heart failure following myocardial infarction irrespective of diabetes status. While the findings suggest an inherent cardioprotective capacity, mechanism remains unknown. We studied infarct size (IS) ex-vivo in isolated hearts exposed to global IR injury in-vivo rats subjected regional ischemia reperfusion (IR) injury, whom we followed left ventricular dysfunction 28 days. compared...
Wild-type transthyretin amyloid (ATTRwt) cardiomyopathy is increasingly recognized in the development of heart failure. The link between cardiac performance, hemodynamics, and mitochondrial function disease stages ATTRwt has not previously been studied but may provide new insights into pathophysiology clinical performance patients.
Background. Strategies to minimize ischemic damage during heart transplantation (HTX) by donation after circulatory death (DCD) are warranted because the inevitable injury linked DCD HTX deteriorates mitochondrial respiratory capacity and ultimately graft quality. This study aimed examine myocardial function with hypothermic oxygenated machine perfusion (HOPE) compare effect of normothermic regional (NRP) that direct procurement (DPP). Methods. A porcine model was used hearts subjected...
Elevation of the plasma levels (S)-lactate (Lac) and/or (R)-beta-hydroxybutyrate (BHB) occurs naturally in response to strenuous exercise and prolonged fasting, respectively, resulting millimolar concentrations these two metabolites. It is increasingly appreciated that Lac BHB have wide-ranging beneficial physiological effects, suggesting novel nutritional solutions, compatible with high-level sustained consumption, which allow direct control BHB, are strong interest. In this study, we...
Abstract Inhibition of succinate dehydrogenase (SDH) by Dimethyl Malonate (DiMal) reduces cardiac ischemia–reperfusion (IR) injury. We investigated the cardioprotective effect DiMal in a rat model during advancing type 2 diabetes. Zucker Diabetic Fatty rats and lean controls were corresponding to prediabetes, onset mature Hearts mounted an isolated perfused model, subjected IR for investigation infarct size (IS) mitochondrial respiratory control ratio (RCR). was administered 10 min before...
Introduction Aerobic capacity is a strong predictor of cardiovascular mortality. Whether aerobic influences myocardial ischemia and reperfusion (IR) injury unknown. Purpose To investigate the impact intrinsic differences in cardioprotective potential on IR injury. Methods We studied hearts from rats developed by selective breeding for high (HCR) or low (LCR) treadmill running. The were randomized to: (1) control, (2) local ischemic preconditioning (IPC) (3) remote (RIC) followed 30 minutes...
Introduction: Cardiac transplantation following circulatory death (DCD) and normothermic regional perfusion (NRP) is a new strategy that allows assessment of cardiac function therapeutical interventions before transplantation. Sodium-3-hydroxybutyric acid (3-OHB) increases output by 40% in heart failure patients diminishes ischemia reperfusion (IR) injury, presumably improving mitochondrial energy metabolism. Hypothesis: We hypothesize infusion with 3-OHB during NRP improves hemodynamic...
Introduction: The role of skeletal muscle mitochondrial dysfunction in exercise intolerance heart failure patients is unknown. Therefore, this study aimed to identify the relationship between physical capacity and function with reduced ejection fraction (HFrEF). Methods A total 53 HFrEF 20 age- sex-matched controls underwent dual-energy X-ray absorptiometry assess mass by appendicular lean index (ALMI), cardiopulmonary testing (peakVO2), 6-minute walking test (6MWD) maximal isometric...