A5035025940- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Ultrasound in Clinical Applications
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Cardiac Arrest and Resuscitation
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Cardiac Structural Anomalies and Repair
- Soft Robotics and Applications
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
Aarhus University Hospital
2016-2025
Aarhus University
2023-2025
Regionshospitalet Herning
2024
GTx (United States)
2016
Regional Hospital Randers
2016
Heart failure triggers a shift in myocardial metabolic substrate utilization, favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that 14-day treatment with ester (KE) would improve resting and exercise hemodynamics capacity patients heart reduced ejection fraction.
Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared sodium-matched sodium chloride (SAL). Eight healthy male participants were randomized in controlled, single-blinded, crossover study. Each participant received four-hour SAL order. Assessor-blinded echocardiography blood samples performed. The primary endpoint...
Abstract Background Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate preferred oxidative substrate for stressed myocardium. Exogenous infusion increases cardiac output (CO). The exact mechanism underlying this has yet to be elucidated. aim study was investigate the cardiovascular mechanisms acute haemodynamic effects exogenous in an experimental model human-sized pigs. Methods In randomised, blinded crossover eight 60-kg-pigs, pigs received...
Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality in patients type 2 diabetes (T2DM). Acute increases circulating levels ketone body 3-hydroxybutyrate have beneficial acute hemodynamic effects without T2DM chronic heart reduced fraction. However, the cardiovascular prolonged oral ester (KE) treatment HFpEF remain unknown.
Background Pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary (CTEPH) are debilitating diseases with a high mortality. Despite emerging treatments, vascular resistance frequently remains elevated. However, the ketone body 3-hydroxybutyrate (3-OHB) may reduce in these patients. Hence, aim was to assess hemodynamic effects of 3-OHB patients PAH CTEPH. Methods and Results We enrolled (n=10) CTEPH residual hypertension. They received infusion placebo (saline) for 2 hours...
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) by 35% to 40% in healthy people and with heart failure. mechanisms underlying the effects of 3-OHB on myocardial contractility loading conditions as well cardiovascular its enantiomeric forms, D-3-OHB L-3-OHB, remain undetermined.
Background The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output (CO) in patients with heart failure through unknown mechanisms. 3-OHB activates the hydroxycarboxylic acid receptor 2 (HCA2), which prostaglandins and suppresses circulating free fatty acids. We investigated whether cardiovascular effects of involved HCA2 activation if potent HCA2-stimulator niacin may increase CO. Methods Results Twelve reduced ejection fraction were included a randomized crossover study examined...
Butyrate, a short-chain fatty acid, has shown potential to improve left ventricular (LV) function and induce vasorelaxation in rodents. Butyrate may either be produced by the microbiome colon, ingested or administered intravenously. This study aimed evaluate effects of butyrate on cardiac output (CO) associated hemodynamic variables porcine model. In randomized, blinded crossover study, ten healthy 60-kg pigs were given three hour infusions 600 mM equimolar sodium chloride (control). CO was...
Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment lactate improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of administration in CS lacking, the mechanisms underlying cardiovascular effects not yet been elucidated. In study we aimed cardiometabolic treatment experimental ischemic CS. a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery...
Abstract Evaluating right ventricular (RV) function remains a challenge. Recently, novel echocardiographic assessment of RV myocardial work (RVMW) by non-invasive pressure-strain loops was proposed. This enables evaluation ventriculoarterial coupling and quantifies dyssynchrony post-systolic shortening. We aimed to assess RVMW in patients with different etiologies dysfunction healthy controls. investigated controls (n=17), severe functional tricuspid regurgitation (FTR; n=22), precapillary...
Lactate is a decisive intermediary metabolite, serving as an energy substrate and signaling molecule. The present study examines the effects of lactate on metabolism insulin sensitivity in healthy males. Hyperlactatemia reduces lipolysis by 30% without affecting glucose metabolism. In addition, hyperlactatemia increases whole body amino acid turnover rate.
The palpation technique is generally used for radial artery catheterisation, but associated with a high rate of failure and complications. Dynamic needle tip positioning (DNTP) new ultrasound-guided technique. We aimed to compare the traditional DNTP performed by four anaesthesiology residents.The study was randomised, controlled, patient-blinded, crossover study. Fourty patients underwent bilateral catheterisation using both techniques. primary endpoint first attempt success rate. secondary...
Background Traditional palpation technique for peripheral venous catheter ( PVC ) placement can be challenging. We aimed to compare the Dynamic Needle Tip Positioning DNTP ultrasound with in anaesthetised toddlers undergoing elective, low‐risk procedures. Methods The study was a randomised, controlled, crossover study. Five operators applied both techniques on 50 children < 4 years. primary endpoint first attempt success rate. secondary endpoints were: (1) overall rate, (2) number of skin...
Background Cardiogenic shock (CS) presents a medical challenge with limited treatment options. Positive end-expiratory pressure (PEEP) during mechanical ventilation has been linked clinical benefits in patients CS. This study investigated whether increasing PEEP levels could unload the left ventricle (LV) CS large animal model of LV-CS. Methods Left cardiogenic was induced 26 female pigs (60 kg) by microsphere injections into main coronary artery. In one study, protocol increased (5, 10, and...
Apheresis treatments can be performed with peripheral venous catheters (PVC), although central (CVC) are inserted when PVCs fail or patient history of difficult vascular access prior to the apheresis. Ultrasound guidance for PVC has shown promising results in other settings.To investigate if ultrasound could implemented among apheresis nurses. Second, how implementation affected number CVCs used per patient.Apheresis nurses completed a systematic training program ultrasound-guided access....
Background Oral treatment with the exogenous ketone body 3‐hydroxybutyrate improves cardiac function in patients heart failure reduced ejection fraction, but ketosis is limited to 3 4 hours. Treatment (R)‐1,3‐butanediol (BD) provides prolonged healthy controls, hemodynamic and metabolic profile unexplored fraction. Methods Results This was a randomized, single‐blind, placebo‐controlled, crossover study. Transthoracic echocardiography venous blood samples were performed at baseline hourly for...
Purpose Vein punctures are performed daily to sample blood. Ultrasound (US) offers an alternative the blind landmark technique for difficult vascular access. A challenge this procedure is presence of US gel in puncture area. We present a US-guided from extremity veins not palpable or visible human eye, while keeping area dry and gel-free. Methods Ten healthy volunteers underwent two vein that were neither nor visible. One was drawn antebrachial another brachial vein. sterile barrier drape...
Beta-hydroxybuturate (