A5049274405- Acute Myeloid Leukemia Research
- Apelin-related biomedical research
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Click Chemistry and Applications
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- COVID-19 and Mental Health
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Chemical Synthesis and Analysis
- Kruppel-like factors research
- Synthesis and Catalytic Reactions
- Colorectal and Anal Carcinomas
- Biosensors and Analytical Detection
- Inflammatory Biomarkers in Disease Prognosis
- CAR-T cell therapy research
- Healthcare professionals’ stress and burnout
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Thyroid and Parathyroid Surgery
- Phytochemical compounds biological activities
Harbin Medical University
2020-2025
Second Affiliated Hospital of Harbin Medical University
2021-2025
Gansu Agricultural University
2024
Zhengzhou University
2014-2024
Henan Cancer Hospital
2023-2024
Capital Medical University
2012-2023
Beijing YouAn Hospital
2023
Sun Yat-sen University
2021-2023
Peking University
2023
Sun Yat-sen Memorial Hospital
2021-2023
Objective: Cardiac dysfunction caused by sepsis, usually termed sepsis-induced cardiomyopathy (SIC), is one of the most serious complications and ferroptosis can play a key role in this disease. In study, we identified cuproptosis- ferroptosis-related genes involved SIC further explored drug candidates for treatment SIC. Methods: The GSE79962 gene expression profile patients was downloaded from Gene Expression Omnibus database (GEO). data used to identify differentially expressed (DEGs)...
Abstract Objective This study employed bioinformatics techniques to identify diagnostic genes associated with programmed cell death (PCD) and explore potential therapeutic agents for the treatment of sepsis. Methods Gene expression profiles from sepsis patients were analyzed differentially expressed (DEGs) hub through Weighted Co-expression Network Analysis (WGCNA). Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses conducted elucidate functions DEGs. PCD-related cross-referenced...
Background The diagnosis of radioiodine refractory differentiated thyroid cancer (RAIR-DTC) is primarily based on clinical evolution and iodine uptake over the lesions, which still time-consuming, thus urging a predictive model for timely RAIR-DTC informing. aim this study was to develop nomogram RAIR prediction among DTC patients with distant metastases (DM). Methods Data were extracted from treatment follow-up databases Peking Union Medical College Hospital between 2010 2021. A total 124...
The ratio of C-reactive protein to albumin (CAR) is an inflammatory marker that has been demonstrated be a simple and reliable prognostic factor in several solid tumours chronic lymphocytic leukaemia (CLL). However, no studies have investigated the value CAR patients with acute myeloid (AML).We retrospectively analysed 212 newly diagnosed non-M3 AML patients. Using receiver operating characteristic curve (ROC) method, optimal cut-off for was determined. We correlations pretreatment levels...
Despite recent progress in multiple myeloma (MM) treatments, most patients will relapse and require additional treatment. Intravenous daratumumab, a human IgGκ monoclonal antibody targeting CD38, has shown good efficacy the treatment of MM. A subcutaneous version daratumumab was formulated to reduce burden intravenous infusions. We aimed investigate safety Chinese with relapsed/refractory MM based on demonstrated noninferiority shorter administration time reduced infusion-related reaction...
Soybean genomic clones were isolated based on hybridization to probes that code for the conserved biotinylation domain of biotin-containing enzymes. The corresponding cDNA was and expressed in Escherichia coli through fusion bacterial trpE gene. resulting chimeric protein biotinylated E. coli. Antibodies raised against reacted specifically with an 85-kDa polypeptide from soybean inhibited 3-methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) activity cell-free extracts leaves. Thus, gene subunit...
Severe myocardial dysfunction and tissue damage resulting from ischemia/reperfusion (I/R) is a common clinical scenario in patients with certain types of heart diseases therapies such as thrombolysis, percutaneous coronary intervention, artery bypass grafting, cardiac transplantation. The underlining mechanism endogenous protection after I/R injury has been focus current research. Growing evidences suggests that soluble receptor for advanced glycation end-products (sRAGE) cardioprotective...
The gut-liver axis in ruminants can explain nutrient regulation, the cycle, and immune function ruminant biology through gut microbe-gut metabolite-liver metabolite relationship. to investigate effects of herbal feed additives on Hu sheep. In this study, a broadly targeted UPLC-MS/MS metabolomics approach 16s sequencing microorganisms were used detect, identify quantify changes ileal microorganisms, liver metabolites following addition Chinese preparations. 0.5% additive increased IgA, IgG...
This study aimed to assess the influence of ulinastatin (UTI) on lymphocyte apoptosis and autophagy in sepsis patients, as well its effect inflammatory factors vital organ function, with goal providing insights for improved clinical management sepsis. A total 40 patients were randomly assigned UTI group or control group. The received standard treatment plus intravenous UTI, while alone. Peripheral blood samples collected at multiple time points analysis apoptosis, autophagy, markers,...
Background: Gemcitabine and cisplatin combined with conventional radiotherapy in treating patients cervical cancer, resulted a favourable conclusion but accompanied high toxicity. The objective of our research was to assess the tolerability, efficacy feasibility dual chemotherapy addition image-guided adaptive brachytherapy highly conformal external beam radiation therapy. Methods & Materials: From June 2011 November 2013, 81 cancer FIGO stage IB2-IIIB medical records were retrospectively...
Elevated pretreatment lactate dehydrogenase (LDH) has been associated with poor prognosis in various malignancies; however, its prognostic role hypopharyngeal cancer remains elusive. In this study, we aimed to assess the association between LDH and clinical outcome of cancer.We retrospectively collected 198 patients treated surgery our institution 2004 2018. The was explored by using univariate multivariate analyses. Besides, subgroup analysis performed based on T stage.Three-year Five-year...
A reverse transcription-free, label-free and enzyme-free colorimetric method is developed for RNA nucleic acid fragment detection. The simultaneously responds to dual viral gene fragments distinguishes single nucleotide polymorphisms.