A5047437412- Retinal Diseases and Treatments
- Protein Structure and Dynamics
- Connexins and lens biology
- RNA and protein synthesis mechanisms
- Retinal Development and Disorders
- DNA and Nucleic Acid Chemistry
- Membrane Separation Technologies
- Wastewater Treatment and Nitrogen Removal
- Calpain Protease Function and Regulation
- Advanced Glycation End Products research
- Electron Spin Resonance Studies
- S100 Proteins and Annexins
- Higher Education and Teaching Methods
- Heat shock proteins research
- Retinopathy of Prematurity Studies
- Recycling and Waste Management Techniques
- Education and Work Dynamics
- Epigenetics and DNA Methylation
- Advanced Battery Materials and Technologies
- Environmental Changes in China
- Adsorption and biosorption for pollutant removal
- Advancements in Battery Materials
- Retinal Imaging and Analysis
- Extraction and Separation Processes
- Photosynthetic Processes and Mechanisms
University of Michigan
2013-2024
Michigan United
2017-2020
North China University of Science and Technology
2019
Harbin Institute of Technology
2013-2018
Stanford University
2015-2018
Wayne State University
2015-2017
Kresge Eye Institute
2016-2017
Zhejiang University of Technology
2014-2016
Inner Mongolia Agricultural University
2016
Invitae (United States)
2016
Abstract The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause blindness worldwide. Here we set out to explore Akt2 signaling—integral both RPE homeostasis and glucose metabolism—to DR. Using human tissue genetically manipulated mice (including RPE-specific conditional knockout (cKO) knock-in (KI) mice), investigate whether Akts influences DR models eye disease. We found that Akt1 activities were reciprocally regulated...
Petroleum-based plastic pollution has been a global environmental concern for decades. The obvious contrast between the remarkable durability of plastics and their short service time leads to increasing accumulation wastes in environment. A cost-effective, sustainable strategy solve problem should focus on source control clean up. Polystyrene (PS) wastes, recalcitrant polymer, are among wide spread man-made pollutants. Destruction PS can be achieved using various abiotic methods such as...
BACKGROUND. This study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying alterations associated with severity DR.
Helix-junction-helix (HJH) motifs are flexible building blocks of RNA architecture that help define the orientation and dynamics helical domains. They also frequently involved in adaptive recognition proteins small molecules formation tertiary contacts. Here, we use a battery nuclear magnetic resonance techniques to examine how deleting single bulge residue (C24) from human immunodeficiency virus type 1 (HIV-1) transactivation response element (TAR) trinucleotide (U23-C24-U25) affects over...
A Gram-negative, aerobic, short rod-shaped, non-motile, pale-yellow bacterial strain was isolated from biological soil crusts collected in the desert of Kubuqi, Inner Mongolia China, designated MIMBbqt12T. The G+C content genomic DNA MIMBbqt12T 49.5 mol%. Phylogenetic analysis using 16S rRNA gene sequences showed that belongs to genus Spirosoma with highest sequence similarity 93.5 % arcticum R2-35T. major fatty acids were C16 : 0, iso-C15 iso-C17 03-OH, 1ω5c and summed feature 3 (C16 1ω6c...
Purpose: We have previously demonstrated that HspB4/αA-crystallin, a molecular chaperone, plays an important intrinsic neuroprotective role during diabetes, by its phosphorylation on residue 148. also reported HspB4/αA-crystallin is highly expressed glial cells. There growing interest in the potential causative of low-grade inflammation diabetic retinopathy pathophysiology and retinal Müller cells’ (MGCs’) participation inflammatory response. MGCs indeed play central homeostasis via...
HSPB4 and HSPB5 (α-crystallins) have shown increasing promise as neuroprotective agents, demonstrating several anti-apoptotic protective roles in disorders such multiple sclerosis diabetic retinopathy. HSPs are highly regulated by post-translational modification, including deamidation, glycosylation, phosphorylation. Among them, T148 phosphorylation has been to regulate the structural functional characteristics of underlie, part, its capacity. We recently demonstrated that this is reduced...
A growing number of studies employ time-averaged experimental data to determine dynamic ensembles biomolecules. While it is well-known that different can satisfy within error, the extent and nature these degeneracies, their impact on accuracy ensemble determination remains poorly understood. Here, we use simulations a recently introduced metric for assessing similarity explore degeneracies in determining using NMR residual dipolar couplings (RDCs) with specific application A-form helices...
<h3>Abstract</h3> Expression and secretion of neurotrophic factors have long been known as a key mechanism neuroglial interaction in the central nervous system. In addition, several other intrinsic neuroprotective pathways described, including those involving small heat shock proteins such α-crystallins. While initially considered purely intracellular mechanism, both αA-crystallins αB-crystallins recently reported to be secreted by glial cells. an anti-apoptotic effect αA-crystallin has...
Patients may lose part of the hand-gripping force, because diseases stroke, carpal tunnel syndrome, nerve damage etc, which lead to greatly inconvenience during their daily life. The research work in this area has been really investigated world, and is with significant importance medical military areas. A mechanical exoskeleton system designed project for improving force these patients. includes five parts: framework, finger motion intention detecting system, extra output joints’ angle...
Computational fluid dynamics (CFD), which is a widely used technique, has been applied to the wastewater biological treatment field recently. It can clearly reveal inner flow state that hydraulic condition of reactor. In engineering, it able guide optimization, and even design. This paper reviews application CFD in main reactors, including: stabilization pond, membrane bioreactor activated sludge addition, existing difficulties are thoroughly analyzed from three aspects: current researches,...
In this study, sludge reduction by ultrasound combining anaerobic-anoxic-oxic system (AAO) was developed and examined. Compared with AAO process, 38.07, 46.07 50.98% of excess could be obtained ultrasonic (sludge return ratios 40%, 60%, 80%). When the ratio is can achieve best effect. Chemical oxygen demand (COD) removal rates were 88.21, 89.77, 90.31%, respectively. The introduction disruption pretreatment did not affect COD ability system, whereas increased in efficiency. This combined...
Volatile organic compounds (VOCs), especially toluene as the typical indoor air pollutants, are toxic and environmentally persistent whose removal is undoubtedly becoming increasingly urgent matter over these years. Titania one of most promising photocatalysts for degradation compounds, whereas large band gap titania massive recombination photogenerated charge carriers limit its overall photocatalytic effciency. These defects can be tackled by modifying electronic structure including various...