A5034409308- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Diabetes Management and Research
- Liver Diseases and Immunity
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Acute Kidney Injury Research
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Renal and related cancers
- Bone health and osteoporosis research
- Genetic and Kidney Cyst Diseases
- Bone health and treatments
- Neurofibromatosis and Schwannoma Cases
- Electrolyte and hormonal disorders
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Heart Failure Treatment and Management
University of Michigan–Ann Arbor
2015-2024
Michigan United
2016-2024
Health First
2022
Oakland University
2021
Ann Arbor Center for Independent Living
2017
A. Alfred Taubman Health Care Center
2015
Ann Arbor VA Medical Center
2011-2013
Michigan Medicine
2011-2012
HealthEast Care System
2009
St. Joseph's Hospital
2009
Kidney aging is associated with an increasing proportion of globally scarred glomeruli, decreasing renal function, and exponentially ESRD prevalence. In model systems, podocyte depletion causes glomerulosclerosis, suggesting age-associated glomerulosclerosis could be caused by a similar mechanism. We measured number, size, density, glomerular volume in 89 normal kidney samples from living deceased donors poles nephrectomies. Podocyte nuclear density decreased age due to combination number...
Studies of lipids in CKD, including ESRD, have been limited to measures conventional lipid profiles. We aimed systematically identify 17 different classes and associate the abundance thereof with alterations acylcarnitines, a metric β -oxidation, across stages CKD. From Clinical Phenotyping Resource Biobank Core (CPROBE) cohort 1235 adults, we selected panel 214 participants: 36 stage 1 or 2 99 3 61 4 18 5 Among participants, 110 were men (51.4%), 64 black (29.9%), 150 white (70.1%), mean...
Model systems demonstrate that progression to ESRD is driven by progressive podocyte depletion (the hypothesis) and can be noninvasively monitored through measurement of urine pellet mRNAs. To test these concepts in humans, we analyzed mRNAs from 358 adult pediatric kidney clinic patients 291 controls (n=1143 samples). Compared with controls, increased 79-fold (P<0.001) biopsy-proven glomerular disease a 50% decrease function or ESRD. An independent cohort Alport syndrome had 23-fold...
BACKGROUND. In this study, we identified the lipidomic predictors of early type 2 diabetic kidney disease (DKD) progression, which are currently undefined.
Human studies report conflicting results on the predictive power of serum lipids progression chronic kidney disease (CKD). We aimed to systematically identify that predict end-stage disease.From Chronic Renal Insufficiency Cohort, 79 patients with CKD stage 2 3 who progressed ESKD over 6 years follow up were selected and frequency-matched by age, sex, race, diabetes 121 non-progressors less than 25% decline in estimated glomerular filtration rate (eGFR) during up. The randomly divided into...
The attrition rate of functioning allografts beyond the first year has not improved despite immunosuppression, suggesting that nonimmune mechanisms could be involved. Notably, glomerulopathies may account for about 40% failed kidney engraftment, and glomerulosclerosis progression to ESRD are caused by podocyte depletion. Model systems demonstrate nephrectomy can precipitate hypertrophic stress triggers progressive depletion leading ESRD, this process is accompanied accelerated detachment...
Abstract Background: Population-based interventions aimed at halting the increasing prevalence of metabolic syndrome (MetS) require thorough understanding dietary interplays. Objective is to identify independent nutrients associated with MetS and its components using pattern identification single-nutrient approaches in The United States. Methods: This a cross-sectional observation. Participants are selected from National Health Nutrition Examination Survey (NHANES) available intake,...
The association of hypoalbuminemia with osteoporosis in human studies is controversial.We tested the independent between and a national dataset.This cross-sectional observation.Participants are individuals selected from National Health Nutrition Examination Survey (NHANES) available clinical, laboratory, densitometry data 2005-2010 2013-2014 cycles.Exposure defined as serum albumin <3.5 g/dL.Osteoporosis bone mineral density ≤2.5 SD below mean peak mass young, healthy adults. Analysis took...
OBJECTIVES Patients with type 1 diabetes (T1D) exhibit modest lipid abnormalities as measured by traditional metrics. This study aimed to identify lipidomic predictors of rapid decline kidney function in T1D. RESEARCH DESIGN AND METHODS In a case-control study, 817 patients T1D from three large cohorts were randomly split into training and validation subsets. Case was defined &gt;3 mL/min/1.73 m2 per year estimated glomerular filtration rate (eGFR), while control &lt;1 over minimum...
Abstract Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known risk factors, suggesting lipid profiles early during may identify individuals who develop later the disease course. This retrospective cohort study examined 10 years prior to diabetic assessment. Methods Participants comprised members of Gila River Indian community ( n = 69) available stored samples assessment using combined Michigan...
<b><i>Introduction:</i></b> Metabolomics could offer novel prognostic biomarkers and elucidate mechanisms of diabetic kidney disease (DKD) progression. Via metabolomic analysis urine samples from 995 CRIC participants with diabetes state-of-the-art statistical modeling, we aimed to identify metabolites DKD <b><i>Methods:</i></b> Urine (<i>N</i> = 995) were assayed for relative metabolite abundance by untargeted flow-injection mass...
Human studies have reported conflicting results on the association of hypoalbuminemia with osteoporosis.
The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 5 collagen IV chains resulting in glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured urine increased AS, suggesting depletion could play a role causing progressive loss kidney function. To test this hypothesis podometric parameters were 26 biopsies from 21 patients aged 2–17 years with clinic-pathologic diagnosis including classic thin...
Abstract The antioxidant effect of three different extracts Morus nigra fruit (fruit juice, hydroalcoholic and polyphenolic) on haemoglobin glycosylation, peroxidative damage to human erythrocytes, liver hepatooytes rats low‐density lipoprotein (LDL) were studied. results show that all inhibited glycosylation induced by glucose differing degrees. haemolysis erythrocytes hydrogen peroxide was also inhibited. production malondialdehyde (MDA) during plasma membranes isolated rat hepatocytes...
BackgroundSpontaneous renal artery dissection (SRAD) is a rare entity of unknown etiology. We aimed to study the clinical course and outcomes compare characteristics patients with SRAD those general population.
<b><i>Background:</i></b> The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by microbiota, outcomes <b><i>Methods:</i></b> SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform baseline plasma samples from 214 CKD enrolled Clinical...
Abstract Motivation Functional enrichment testing methods can reduce data comprising hundreds of altered biomolecules to smaller sets biological ‘concepts’ that help generate testable hypotheses. This study leveraged differential network analysis methodology identify and validate lipid subnetworks potentially differentiate chronic kidney disease (CKD) by severity or progression. Results We built a partial correlation interaction network, identified highly connected components, applied...
BACKGROUND. This study systematically investigated circulating and retinal tissue lipid determinants of human diabetic retinopathy (DR) to identify underlying alterations associated with severity DR.
<b><i>Background:</i></b> The role of myeloperoxidase in chronic kidney disease (CKD) and its association with coronary artery (CAD) is controversial. In this study, we compared protein-bound 3-chlorotyrosine (ClY) levels subjects varying degrees CKD tested their associations CAD.<b><i> Methods:</i></b> From Clinical Phenotyping Resource Biobank Core, 111 patients were selected from stages 1 to 5. Plasma level was measured using...
Kidney function decreases with age. A potential mechanistic explanation for kidney and allograft half-life has evolved through the realization that linear reduction in glomerular podocyte density could drive progressive glomerulosclerosis to impact both native half-lives.
Non-traditional risk factors like inflammation and oxidative stress play an essential role in the increased cardiovascular disease (CVD) prevalent chronic kidney (CKD). Tryptophan catabolism by kynurenine pathway (KP) is linked to systemic CVD general dialysis population. However, relationship of KP incident CKD population unknown.