A5043125108- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- AI in cancer detection
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Frailty in Older Adults
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Colorectal Cancer Surgical Treatments
- Folate and B Vitamins Research
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
Erasmus MC Cancer Institute
2021-2023
Erasmus MC
2023
This study aimed to describe the treatment of metachronous colorectal cancer metastases in a recent population-based cohort.Patients with stage I-III (CRC), diagnosed between January 1st and June 30th, 2015 who were surgically treated curative intent selected from Netherlands Cancer Registry. Follow-up was at least 3 years after diagnosis primary tumour. Treatment categorized into local treatment, systemic best supportive care. Overall survival estimated using Kaplan-Meier method.Out 5412...
Maintaining a sufficient health-related quality of life (HRQoL) is important in the palliative treatment patients with metastatic colorectal cancer (mCRC). The ORCHESTRA trial (ClinicalTrials.gov identifier: NCT01792934) designed to prospectively evaluate overall survival benefit and impact on HRQoL tumor debulking when added first-line systemic therapy multiorgan mCRC. In present study, we report associated this combination compared standard therapy.Patients included clinical after 3 or 4...
The aim of this study was to evaluate the Dutch regional practice variation in treatment synchronous colorectal liver metastases (CRLM) over time and assess their impact on patients survival.Two cohorts with CRLM were selected from Netherlands Cancer Registry (NCR). All diagnosed between 2014 2018 analyze interregional variations local therapy (LT) multivariable logistic regression. Overall survival (OS) assessed for 2008 2013 using Kaplan Meier method Cox regression analyses.The proportion...
Abstract Background Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP multi-organ inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy CRLM. Methods Patients undergoing resection CRLM perioperative systemic two centers were included. Survival...
Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunotherapy efficacy reported patients with LM, tumor-infiltrating lymphocytes (TIL) have not yet been investigated BCLM. Here, we evaluate distribution of HGP TIL BCLM, their association clinicopathological variables survival. We collect samples from surgically resected BCLM (n = 133...
Abstract Background: Liver metastases (LM) are ultimately present in ~50% of all patients with metastatic breast cancer (BC). Metastatic seeding to the liver relies on interaction between cells and host microenvironment, resulting into two main histopathological growth patterns (HGPs): replacement HGP (metastasis mimics architecture exploits vasculature) desmoplastic (presence a fibrotic rim separating hepatocytes from tumor cells). While prognostic value these HGPs is established for...
Abstract Histopathological growth patterns (HGPs) of liver metastases represent a potential biomarker for prognosis after resection. They have never been studied in neuroendocrine tumor (NETLM). This study evaluated if distinct HGPs can be observed resected NETLM and they prognostic value. Sixty-three patients who underwent resection between 01–01-2001 31–12-2021 were retrospectively included. scored on Haematoxylin&Eosin slides using light microscopy, distinguishing desmoplastic-...
Histopathological Growth Patterns (HGPs) have prognostic and predictive value in patients with Colorectal Liver Metastases (CRLM). This study examined whether preoperative measurement of Circulating Tumour Cells (CTCs) is associated HGP. CTCs were prospectively enumerated 7.5 ml blood using the FDA-approved CellSearch system who underwent local treatment CRLM curative intent between 2008 2021. All CTC samples collected on day treatment. Patients treated neoadjuvant chemotherapy for or...
Abstract The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, further substantiated potential clinical value HGPs patients with from various tumour types and are starting to shed light on biology distinct HGPs. In present we give an overview studies, discuss novel strategies predicting metastases, such as deep learning algorithms whole slide...
Sarcopenia is associated with impaired short- and long-term outcomes in gastrointestinal cancers. Whether sarcopenia survival after local therapy of Colorectal Cancer Liver Metastases (CRLM) remains controversial. This study aimed to determine the influence on curative-intent for CRLM.Patients undergoing CRLM between 2003 2019 were retrospectively analyzed using skeletal muscle index at level third lumbar vertebra as an indicator sarcopenia. Factors overall (OS) disease-free (DFS)...
Abstract Introduction: Recurrence risk after curative surgery for colorectal liver metastases (CRLM) remains high, underlining the need novel prognostic markers. Liquid biopsies provide promising biomarkers to detect minimal residual disease (MRD) local treatment. The aim of this study was determine and compare characteristics cell-free DNA (cfDNA) circulating tumor (ctDNA) in liquid taken before surgical treatment CRLM. Materials & Methods: Patients with isolated CRLM were recruited...