A5049019988- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Coenzyme Q10 studies and effects
- Vitamin D Research Studies
- Biochemical Acid Research Studies
- Neuroscience and Neuropharmacology Research
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Heart Rate Variability and Autonomic Control
- Cancer, Stress, Anesthesia, and Immune Response
- Heart Failure Treatment and Management
- Adenosine and Purinergic Signaling
- Anatomy and Medical Technology
- Biochemical Analysis and Sensing Techniques
- Neuroendocrine regulation and behavior
- Parasitic Diseases Research and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory mediators and NSAID effects
- Cardiovascular Issues in Pregnancy
- Perfectionism, Procrastination, Anxiety Studies
- Hormonal Regulation and Hypertension
- Cancer and Skin Lesions
University of Nis
2004-2024
University of Veterinary Medicine in Košice
2015
University of Belgrade
2007
Institut za Reumatologiju
2006
Objectives: The nuclear factor κB regulates the expression of genes involved in many processes that play a key role development and progression cancer.The aim this study was to examine infl uence alpha lipoic acid chemoprevention colon cervix carcinoma vitro.Background: In recent years, special attention has been paid potential chemopreventive properties antioxidants.There are no published data on impact lipoc cancer.Methods: We examined effect alone or combination with cisplatin 5-fl...
Recent studies revealed a strong association between vitamin D (VD) status and chronic heart failure (CHF). It is now commonly considered that proinflammatory immune response underlies CHF development.Since VD expresses anti-inflammatory properties, we investigated its impact on cytokines implicated in CHF, such as TNFα IL-17, patients suffering from CHF.Blood was obtained forty with secondary to hypertension and/or coronary disease. status, IL-17 levels were assessed using 25-hydroxy VD3...
Acetylcholine interacts with endothelial muscarinic receptors releasing nitric oxide and causing vasodilatation. To identify the receptor subtype responsible for acetylcholine‐induced relaxation in canine uterine artery, usual organ bath method vitro investigation on isolated blood vessels was applied. Using a range of antagonists such as atropine (nonselective), pirenzepine (M 1 ‐selective), methoctramine 2 ‐selective) p ‐fluoro‐hexahydro‐sila‐difenidol ( ‐FHHSiD) /M 3 ) determining pA2...
In this study, a major part of genome the pestivirus isolate 297 from Slovakia, comprising 7195 nt-long 5΄-UTR-NS3 region was sequenced and analyzed.Conserved cleavage sites between individual viral proteins were determined number amino acids respective estimated as follows: 168 for N pro , 100 C, 227 E rns 195 E1, 373 E2, 70 p7, 453 NS2, 683 NS3.Based on sequence phylogenetic analysis 5΄-UTR, E2 characterized border disease virus genotype 3. It found to be distinct other BDV-3 strains...
Various in silico methods were employed for the development of antipsychotic agents by dopamine transporter inhibition.
The purposes of this study were to examine the therapeutic response advanced cervical cancer Ki-67 proliferative index (Ki-67 PI) dependent cisplatin chemotherapy, and determine PI referential value that is expected provide a satisfactory chemotherapy.This prospective enrolled 59 patients treated for at Clinic Oncology, Clinical Center Nis, Serbia. According obtained values, divided into three groups, all received same cytostatic, cisplatin. Therapeutic chemotherapy was evaluated in relation...
The effect of acetylcholine (ACh) on the isolated, nonprecontracted perforating branch human internal mammary artery (HIMA) was investigated. ACh induced concentration-dependent contractions rings with denuded endothelium (pEC(50) = 6.72 +/- 0.02, E(max) 88.8% by phenylephrine, 10(-5) mol/l) and without arterial segments intact endothelium. An inhibitor nitric oxide synthase, N(G)-monomethyl-L-arginine (L-NMMA), or indometacin, a cyclooxygenase inhibitor, had no acetylcholine-induced HIMA...
The effect of acetylcholine (ACh) on the isolated perforating branch human internal mammary artery (HIMA) was investigated. ACh induced concentration- and endothelium-dependent relaxation arterial rings precontracted with phenylephrine (pEC(50) = 6.93 +/- 0.01). muscarinic receptor antagonist atropine (no selectivity), pirenzepine (M(1)), methoctramine (M(2)), p-fluoro-hexahydro-siladifenidol (M(1)/M(3)) competitively antagonized response to ACh. pA(2) values were 9.81 0.15, 7.74 0.08, 6.27...
The aim was to examine the influence of endothelium on acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) functional responses in isolated glandular branch rabbit facial artery precontracted with phenylephrine as well potential contribution nitric oxide (NO) prostanoids ACh‐ VIP‐induced effects. Acetylcholine caused endothelium‐dependent VIP endothelium‐independent relaxations artery. effect ACh partly inhibited by N G ‐monomethyl‐ l ‐arginine ( ‐NMMA, a non‐selective NO...
Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these can mediate endothelium-dependent responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) human submandibular artery. evaluated contributions endothelial vessel relaxation response ACh VIP, using different inhibitors vasodilation, nitric oxide synthase inhibitor, cyclo-oxygenase indomethacin, potassium channel blocker, 4-aminopyridine. VIP caused...
The effect of acetylcholine on the isolated, non‐precontracted, porcine internal mammary artery (IMA) was investigated. Acetylcholine induced concentration‐dependent contractions non‐precontracted IMA rings with denuded endothelium (pEC 50 = 5.80 ± 0.04) and without arterial segments intact endothelium. muscarinic receptor antagonists atropine, pirenzepine, methoctramine p‐fluoro‐hexahydro‐sila‐diphenidol (pFHHSiD) antagonized response to acetylcholine. constrained pA 2 values were 10.14,...
Summary The effect of acetylcholine on the isolated, pre‐contracted, uterine artery non‐pregnant dog was investigated. Acetylcholine‐induced concentration‐dependent relaxation isolated canine with endothelium (pEC 50 = 6.48 ±0.01, n 37) and without arterial segments denuded endothelium. Indomethacin, 4‐aminopyridine (10 −5 m ) pre‐contraction K + ‐rich Krebs–Ringer bicarbonate solution had no acetylcholine‐induced relaxation. N G ‐nitro‐ l ‐arginine ( ‐NOARG) inhibited evoked by...
Summary The purpose of this study was to examine the effect vasoactive intestinal polypeptide (VIP) on uterine artery obtained from non‐pregnant dogs. VIP (3 × 10 −9 –3 −7 m ) induced concentration‐dependent relaxation in canine arteries with intact endothelium, pre‐contracted l0 −5 phenylephrine (pEC 50 = 7.52 ± 0.02, maximal response 82.19 2.15%, n 36). administration cyclooxygenase inhibitor indomethacin (l0 or 4‐aminopyridine (4‐AP), a blocker potassium channels ), did not modify by VIP....
Non-ionizing radiation has a significant and positive impact on modern society through number of uses. There is increasing public concern regarding the health risks radio-frequency (RF) radiation, particularly that produced by mobile phones. Concern potential exposure to EMFs led many epidemiological investigations, but effects EMF human other mammalian cells are still unclear. One most frequently asked questions about microwave biological systems whether they produce genotoxic could be...
Alpha-lipoic acid (ALA) is a natural, di-thiol antioxidant derived from octanoic acid. It was discovered in 1951 as molecule that participates the transfer of acyl groups Krebs cycle. ALA and its reduced form, dihydrolipoic acid, today represent important factors fight with diseases caused by increased oxidative stress. In human organism synthesized de novo fatty acids cysteine, but very small quantities, so it necessary to be entered external sources through food or adjuvant therapy. The...