Unpredictable drug efficacy and safety of combined antiepileptic therapy is a major challenge during pharmacotherapy decisions in everyday clinical practice. The aim this study was to describe the pharmacokinetics valproic acid (VA), lamotrigine (LTG), levetiracetam (LEV) pediatric population using nonlinear mixed-effect modeling, while machine learning (ML) algorithms were applied identify any relationships among plasma levels three medications patients' characteristics, as well develop...

Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim this study was investigate plants the potential influence health care professionals' advice or media information regarding use herbal dietary supplements with hypoglycemic effect in a population type 2 DM. Materials methods: This research, form an analytic cross-sectional study, conducted 6 pharmacies territory Nis,...

During choledocholitiasis inflammatory oxidant stress involves the promotion of mitochondrial dysfunction through an intracellular in hepatocytes leading mainly to necrosis and less apoptosis. The product oxidative stress, malondialdehyde (MDA), is extremely cytotoxic damages cell membranes macromolecules. toxicity MDA based on its ability act as a mutagenic agent cell. Therefore, aim this prospective study was establish correlation parameters inflammation biochemical markers cholestasis...

Objectives: The nuclear factor κB regulates the expression of genes involved in many processes that play a key role development and progression cancer.The aim this study was to examine infl uence alpha lipoic acid chemoprevention colon cervix carcinoma vitro.Background: In recent years, special attention has been paid potential chemopreventive properties antioxidants.There are no published data on impact lipoc cancer.Methods: We examined effect alone or combination with cisplatin 5-fl...

Antibiotics are the most frequently used drugs in hospitalized patients, but studies have shown that prescribed antibiotics may be inappropriate and contribute to antibiotic resistance. We carried out a survey of consumption resistance our tertiary care university hospital, from 2005 2013. focus on cephalosporins, one groups health care. The objective was identify any relationship between ceftriaxone by enterobacteria.Antibiotics antimicrobial were monitored hospital Data use surgical...

Summary In search for new and promising coumarin compounds as HIV-1 integrase inhibitors, chemoinformatic methods like quantitative structure-activity relationships (QSAR) modeling molecular docking have an important role since they can predict desired activity propose molecule binding to enzyme. The aim of this study was building QSAR models derivatives inhibitors with the application Monte Carlo method. SMILES notation used represent structure defining optimal SMILES-based descriptors....

In this study, a major part of genome the pestivirus isolate 297 from Slovakia, comprising 7195 nt-long 5΄-UTR-NS3 region was sequenced and analyzed.Conserved cleavage sites between individual viral proteins were determined number amino acids respective estimated as follows: 168 for N pro , 100 C, 227 E rns 195 E1, 373 E2, 70 p7, 453 NS2, 683 NS3.Based on sequence phylogenetic analysis 5΄-UTR, E2 characterized border disease virus genotype 3. It found to be distinct other BDV-3 strains...

Abstract The aim of this study was to examine the effect treatment type on anxiety in patients with cervical cancer. Subjects and methods: This prospective conducted 60 cancer treated by radiotherapy. done before treatment, 3 6 months after initial testing. For assessment Hamilton Anxiety Scale (HAM-A) used.: At baseline, values scale who were surgically significantly higher than had been radiotherapy, but intensity gradually decreased both groups. In study, pain irregular menstrual bleeding...

Irrational antibiotic consumption, especially in the case when there is no appropriate indication for its usage, may be one of most crucial global issues public health care, leading to bacterial resistance and increase indirect medical expenses. According report European program monitoring Serbia on fifth place among countries which are not members EU. The goal this work evaluation consumption Clinical Centre Nis, from 2007 2013, with focus cephalosporins utilization, as they prescribed...

The insulin resistance is present when the concentration of normal and biological response decreased. most frequent metabolic change that was detected during anti-hypertension therapy a in resistance. Beta-blockers are generally accompanied by deterioration control patients with diabetes. It considered using certain beta-blockers hypertension diabetes mellitus type 2 (DM 2) can significantly influence Taking into consideration latest knowledge on pharmaco-dynamics analogues beta -blockers,...

The importance of the pharmacist's role in health care has become more pronounced during COVID-19 pandemic as they were accessible and frontline healthcare professionals, who significantly contributed to ensuring uninterrupted access essential services.This research aimed examine experiences community pharmacists regarding quality extent pharmaceutical patient counseling relation pre-pandemic period.Also, this investigate informative considering (possibility infection, symptoms, protection,...

Introduction/Aim. Polypharmacy can increase the risk of side effects and cause adverse drug interactions with a significant impact on course basic disease. The aim study was to determine frequency polypharmacy examine its drug-drug in patients rheumatoid arthritis (RA). research conducted form retrospective cross-sectional study. Material methods. included 131 diagnosed RA, treated during 2019 2020. Demographic data clinical characteristics subjects were collected from medical documentation...

Alpha-lipoic acid (ALA), a naturally-occurring antioxidant, inhibits proliferation and induces apoptosis in various cancer cell lines without effects on normal non-transformed cells.The aim of this study was to examine the alpha-lipoic alone combined with 5-fluorouracil (5-FU), Bcl-2/Bax expression human colon Caco-2 line as well investigate possible molecular mechanisms pathways involved ALA-mediated effects.In present ALA 5-FU showed tendency decrease Bcl-2 increase Bax expression.ALA...

Alpha-lipoic acid (ALA) is a natural, di-thiol antioxidant derived from octanoic acid. It was discovered in 1951 as molecule that participates the transfer of acyl groups Krebs cycle. ALA and its reduced form, dihydrolipoic acid, today represent important factors fight with diseases caused by increased oxidative stress. In human organism synthesized de novo fatty acids cysteine, but very small quantities, so it necessary to be entered external sources through food or adjuvant therapy. The...

Colorectal cancer is in the third most frequent among malignant tumors of both sexes developed countries. It predominantly a disease older persons and occurs mostly after age 60. Although etiology colon unknown, it assumed to arise as result unclear complex interactions between genetic environmental factors. The main element colorectal process changes epithelial cells mucosa. believed that specific epidemiological factors such stress, hypoxia, reduced intake glucose other nutrients,...

In the recent years, there have been considerable discussion and concern about possible hazards of RF/MW radiation. More recently, growth development in personal mobile communications focused attention on frequencies associated with this technology. A number studies examined health effects electromagnetic fields (EMFs), originating from occupational exposure, hobbies, or residence near radio television transmitters. Particularly controversial are biophysical mechanisms by which these RF may...

Previously, we performed population pharmacokinetic analysis and indicated age, mycophenolate mofetil (MMF)/mycophenolic acid (MPA) daily dose, presence of nifedipine in patient therapy as significant predictors MPA apparent clearance (CL/F) variability. This study aimed to determine the reliability previously published models derived from similar studies. Furthermore, this investigated correspondence between chosen literature.By means Monte Carlo simulation method, different studies are...

The aim of this study was to evaluate potential influence cytochrome P450 3A5 (CYP3A5) 6986A>G gene polymorphisms on inter-and intravariability (IPV) in tacrolimus (Tac) exposure within the first year after renal transplantation.Secondary, we aimed analyze change distribution patients regarding IPV between early (<6 months) and late posttransplant period (>6 months).The enrolled 91 transplant recipients, who were Tac-based immunosuppressive protocol.Dose-adjusted concentration (C0/D) Tac...

Introduction: Two most common pharmaceutical formulation of tacrolimus (Tac) used after kidney transplantation (Tx) are immediate-release one, administered twice-daily (TacTD), and prolonged-release once-daily (Tac-OD). Aim: The aim this study was to compare daily doses, trough concentrations (C0 ) dose-adjusted /D) Tac between patients who different drug formulations, Tac-TD or Tac-OD, during the first year Tx. Additionally, distribution C0 within beyond target therapeutic range (8-12 ng/mL...

Pharmacotherapeutic strategies in the treatment of chronic venous disease (CVD) include a wide range venoactive drugs available form over counter medicines and dietary supplements.The aim this study was to investigate selfmedication practice concerning relative influence health care professionals self-initiative on choice pharmacotherapy CVD symptoms.The conducted cross-section epidemiological showed high presence among patients with symptoms, also implied attendance use 35.6% respondents...