Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there a lack evidence explaining the risk factors predisposing to in patients with chronic kidney disease (CKD). This retrospective study was undertaken evaluate incidence and possible for among hospitalized UTI cohort CKD patients. Patients were divided into group non-urosepsis group. Of 489 UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that...

<b><i>Objectives:</i></b> To assess the degree of immunosuppressive medication adherence in kidney transplant patients (KTPs) and to determine if there is a difference rate tacrolimus (Tac), cyclosporine (CsA) sirolimus (Sir). <b><i>Subjects Methods:</i></b> From total 63 KTPs treated at Clinic Nephrology, Clinical Centre Niš, Serbia, 60 participated study by responding questionnaires. They were divided into group (n = 43) nonadherence 17)...

The purpose of this study was to derive population pharmacokinetics (PPK) model tacrolimus clearance, identify and describe factors that influence it in Serbian kidney transplant patients.Population analysis performed using nonlinear mixed-effects (NONMEM) program from adult patients receiving triple immunosuppressive therapy, including oral tacrolimus. Details drug dosage history, sampling time concentration 63 (44 males 19 females), 27 - 57 years old (age mean 40.88 +/- 7.01 years) were...

Background: End-stage renal disease is a state of enhanced oxidative stress (OS) and hemodialysis (HD) anemia further augment this disbalance.Anemia correction with erythropoietin (EPO) may improve status.However, there no evidence time dependent effects EPO therapy on redox status HD patients.Objective: The aim study was to evaluate whether the duration treatment affect OS parameters in uremic patients.Patients methods: 104 patients 29 healthy volunteers were included.Patients divided into...

The clinical use of tacrolimus (Tac) is complicated by the large inter-individual variability in its pharmacokinetics as well chronic adverse effects on renal function. main goal this study was to evaluate potential influence cytochrome P450 3A5 (CYP 3A5) and ATP-binding cassette transporter B1 (ABCB1) gene polymorphisms Tac dose requirements dose-adjusted concentrations different long-term periods following transplantation. Another aim investigate whether these affect function late...

Abstract: Monitoring of tacrolimus blood concentration is utmost importance in the management renal transplant recipients because Narrow Therapeutic Index and highly variable pharmacokinetics. The aim this study was to detect inter‐patient pharmacokinetic variability assess predictability individual concentrations at various times area under curve (AUC) seeking find best sampling time predict exposure with triple therapy. This oral dose pharmacokinetics conducted 18 Serbian on...

The utilization of all potentials small and medium-sized enterprises, in terms their contribution to the growth development national economy poverty reduction, is largely conditioned by degree institutional support provided state through relevant mechanisms. role enterprises particularly important transition countries, which are faced with problems high unemployment, low level economic activity, lack competition, investment dominated large inefficient enterprises. For these reasons, seen one...

Assessment of liver fibrosis is important for making treatment decisions, as well predicting prognosis and therapeutic outcome in patients on chronic hemodialysis (HD) infected with hepatitis C virus (HCV). The aim the present investigation was to evaluate changes standard laboratory tests (AST, ALT, yGT, cholesterol platelet count) indirect serum markers: AST-to-platelet ratio index (APRI), FIB-4 Forns index, chronically HCV-infected maintenance HD without antiviral treatment.A total 38...

Introduction/Aim. Patients who undergo kidney transplantation can encounter significant changes in body composition because of weight gain caused by fat mass accumulation and muscle loss, resulting poor graft outcomes. The study aimed to investigate the impact different obesity parameters on function transplant recipients. Methods. A cross-sectional was conducted 80 patients aged 25-75 years (40% females). All were triple immunosuppressive therapy. Weight, height, waist, hip circumferences...

The idea for Prof. Norman Beaulieu's DL Tour was raised during the Globecom 2013 conference in December Atlanta, when Beaulieu and Zoran Hadzi-Velkov, Chair of R. Macedonia ComSoc Chapter, first discussed it. Distinguished Lecturer organized at beginning 2014 to include four different European countries: Republic Macedonia, Italy, Montenegro, Serbia.

Introduction: Two most common pharmaceutical formulation of tacrolimus (Tac) used after kidney transplantation (Tx) are immediate-release one, administered twice-daily (TacTD), and prolonged-release once-daily (Tac-OD). Aim: The aim this study was to compare daily doses, trough concentrations (C0 ) dose-adjusted /D) Tac between patients who different drug formulations, Tac-TD or Tac-OD, during the first year Tx. Additionally, distribution C0 within beyond target therapeutic range (8-12 ng/mL...

In 2020, the European postal market had significant changes caused by COVID-19 virus pandemic.The analysis is monitored Regulatory Group for Postal Services -ERGP, which an advisory body to Commission.A special place in work of this working group given subgroup "Regulatory framework", with task presenting Commission extent pandemic affected sector EU.The aim paper inform professional public about results ERGP on impact 2020 and measures taken governments, national regulatory agencies...