A5021613748- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Nitric Oxide and Endothelin Effects
- Multiple Sclerosis Research Studies
- Cannabis and Cannabinoid Research
- Metabolism and Genetic Disorders
- Glutathione Transferases and Polymorphisms
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
- Adenosine and Purinergic Signaling
- Neonatal Health and Biochemistry
- Advanced Glycation End Products research
- Redox biology and oxidative stress
- Asthma and respiratory diseases
- Rheumatoid Arthritis Research and Therapies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Neuroscience of respiration and sleep
- Growth Hormone and Insulin-like Growth Factors
- Biochemical and Molecular Research
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Renal Transplantation Outcomes and Treatments
University of Nis
2011-2020
St Petersburg University
2018
Centar za Promociju Nauke
2005-2011
Institute of Biochemistry
1998-2010
University Hospital Medical Center Bezanijska kosa
2007-2008
Cardiff University
2006
Heidelberg University
2006
Inštitut Bion
2002-2003
Agrobioinstitute
1992
Inserm
1991
The aim of the study was to evaluate intensity oxidative stress in brain animals chronically exposed mobile phones and potential protective effects melatonin reducing injury.Experiments were performed on Wistar rats microwave radiation during 20, 40 60 days. Four groups formed: I group (control)- treated by saline, intraperitoneally (i.p.) applied daily follow up, II (Mel)- with (2 mg kg(-1) body weight i.p.), III (MWs)- rats, IV (MWs + Mel)- MWs i.p.). produced a test phone (SAR =...
The effects of a 3-day pneumococcal infection on diaphragmatic strength and endurance capacity were studied in an vivo rat model. Thirty-four rats divided into control (C) (n = 17) or septic (S) group 17). Animals inoculated subcutaneously with 10(11) Streptococcus pneumoniae (S), sterile culture media (C). All 3 days after inoculation. Diaphragmatic 11 animals each group. was assessed by measuring transdiaphragmatic pressure (Pdi) generated during electrical stimulation the phrenic nerves...
The principal metabolic effect of metformin-an oral antihyperglycaemic agent-is the improvement in sensitivity peripheral tissues and liver to insulin. This study examined metformin monotherapy on antioxidative defence system activity erythrocytes plasma diabetic patients. We studied treatment activities Cu, Zn-superoxide dismutase (EC 1. 15. 1.), catalase 11. 6.) glutathione peroxidase 9.) relation lipid peroxidation products reduced level erythrocytes. In this we also erythrocytes'...
Glucocorticoids (GC) are used widely for the treatment of patients with various disorders, including autoimmune diseases, allergies, and lymphoproliferative disorders. Glucocorticoid therapy is often limited by several adverse reactions associated GC excess. Excess can elicit a variety symptoms signs, growth retardation in children; immunosuppression; cardiovascular disorders like hypertension atherosclerosis; osteoporosis; myopathy; diabetes mellitus. Currently, attention focused on...
Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of human multiple sclerosis (MS). We have evaluated the role oxidative and nitrosative stress, as causal factors in development EAE, responsible for damage cardinal cellular components, such lipids, proteins nucleic acids, resulting demyelination, axonal damage, neuronal death. EAE was induced female Sprague-Dawley rats, 3 months old (300 ± 20 g), by immunization with myelin basic protein combination Complete...
The objective of the study was to asses possible influence hypothalamo-pituitary deficiencies, and growth hormone (GH) deficiency in particular, on cognition adult patients with traumatic brain injury (TBI). TBI is a recently identified risk factor for cognitive deficits hypopituitarism. Even favorable outcome after may present persistent bodily, psychosocial, impairments, resembling untreated partial or complete pituitary insufficiency.We performed retrospective cross-sectional endocrine...
Summary Skin aging is a dynamic process that occurs due to chronological and photo-aging caused by the influence of external factors, especially ultraviolet-UV radiation. Cumulative oxidative stress, formation free radicals their adverse effects on biological systems in skin cells common mechanism both processes. The formed reactive oxygen species-ROS can lead oxidation cell`s building molecules. Lipid peroxidation, membrane protein damage DNA mutation may many structural, functional...
The aim of this study was to determine oxidative stress (OS) parameters after testicular torsion/detorsion in adult rats.In experimental study, male Wistar rats were divided into four groups, each consisting seven animals: group I-one hour right torsion with subsequent orchiectomy, II-one followed by detorsion, III-unilateral right-sided orchiectomy without previous and IV-control. After 30 days, bilateral orchiectomies performed both testes unilateral single testicles. Parameters OS...
ABSTRACT Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin receptor (VDR) gene are potentially involved the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which reduces inflammation role VDR SNPs BA not completely understood. The aim this study was to examine possible associations FokI, BsmI, ApaI, TaqI with BA. A total 168 subjects were screened for using polymerase chain reaction restriction fragment length polymorphism (PCR‐RFLP) method. obtained...
The complexation of humic acid with certain heavy metal ions (Co(II), Ni(II), Cu(II), Zn(II) and Pb(II)) was investigated. stability constants humate complexes were determined by method which is based on distribution between solution resin in the presence absence ligand, known as Schubert?s ion exchange method. Experiments performed at 25 ?C, pH 4.0 ionic strength 0.01 mol dm-3. It found that 1:1 formed acid. Obtained results constants, log ?mn, follow order Co(II) < Ni(II) Cu(II) >...
Experimental autoimmune encephalomyelitis (EAE) is a well-established cell-mediated inflammatory disease of the CNS, which has been used as model human demyelinating disease. EAE characterized by infiltration CNS lymphocytes and mononuclear cells, microglial astrocytic hypertrophy, demyelination cumulatively contribute to clinical expression was induced in female Sprague-Dawley rats, 3 months old (300 g +/- 20 g), immunization with myelin basic protein (MBP) combination Complete Freund's...
Cadmium is a widespread, toxic industrial pollutant. The proximal tubule of the mammalian kidney major target Cd-induced toxicity. We analyzed effects cadmium exposure on model system experimental animals, thiobarbituric acid (TBA)-reactive substance (TBARS) level, and activity xanthine oxidase (XO) catalase in rats, with without glutathione lipoic (LA). animals were classified into six groups, regarding cadmium, glutathione, LA intake. concentration TBARSs homogenate was determined by...
Background: End-stage renal disease is a state of enhanced oxidative stress (OS) and hemodialysis (HD) anemia further augment this disbalance.Anemia correction with erythropoietin (EPO) may improve status.However, there no evidence time dependent effects EPO therapy on redox status HD patients.Objective: The aim study was to evaluate whether the duration treatment affect OS parameters in uremic patients.Patients methods: 104 patients 29 healthy volunteers were included.Patients divided into...
Here we report the influence of malondialdehyde (MDA) as a measure lipid peroxidation process (LP), on multiple sclerosis (MS) pathogenesis and its neurological signs, during treatment with aminoguanidine (AG) - selective inducible nitric oxide synthase inhibitor N-Acetyl cysteine (NAC) an oxidative scavenger, in experimental autoimmune encephalomyelitis (EAE), animal model for studying MS.Encephalomyelitis induction by subcutaneous injection myelin basic protein bovine type, dissolved...