Antimicrobial resistance is one of the greatest threats to human health. One most important factors leading emergence resistant bacteria overuse antibiotics. The purpose this study was investigate correlation between antimicrobial usage and bacterial Pseudomonas aeruginosa (P. aeruginosa) over a 10-year period in Clinical Center Niš, biggest tertiary care hospitals Serbia. We focused on possible relationships consumption carbapenems beta-lactam antibiotics rates P. carbapenems.We recorded...

<b><i>Objectives:</i></b> To assess the degree of immunosuppressive medication adherence in kidney transplant patients (KTPs) and to determine if there is a difference rate tacrolimus (Tac), cyclosporine (CsA) sirolimus (Sir). <b><i>Subjects Methods:</i></b> From total 63 KTPs treated at Clinic Nephrology, Clinical Centre Niš, Serbia, 60 participated study by responding questionnaires. They were divided into group (n = 43) nonadherence 17)...

The purpose of this study was to derive population pharmacokinetics (PPK) model tacrolimus clearance, identify and describe factors that influence it in Serbian kidney transplant patients.Population analysis performed using nonlinear mixed-effects (NONMEM) program from adult patients receiving triple immunosuppressive therapy, including oral tacrolimus. Details drug dosage history, sampling time concentration 63 (44 males 19 females), 27 - 57 years old (age mean 40.88 +/- 7.01 years) were...

Background: End-stage renal disease is a state of enhanced oxidative stress (OS) and hemodialysis (HD) anemia further augment this disbalance.Anemia correction with erythropoietin (EPO) may improve status.However, there no evidence time dependent effects EPO therapy on redox status HD patients.Objective: The aim study was to evaluate whether the duration treatment affect OS parameters in uremic patients.Patients methods: 104 patients 29 healthy volunteers were included.Patients divided into...

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The aim of this study was to develop a population pharmacokinetic (PK) model for clearance mycophenolic acid (MPA) in adult renal transplant recipients, quantify the PK parameters and influence covariates on MPA parameters. Parameters associated with plasma concentrations at steady-state were analyzed 70 recipients (mean age 42.97 years; mean total body weight 75.33 kg) using nonlinear mixed-effect modeling (NONMEM). Characteristics patients screened gender, age, weight, time after...

Antibiotics are the most frequently used medications in Serbian hospitalized patients. Information about antibiotic utilization and sensitivity among inpatients Serbia is scanty, there no available publications on topic. The aim of this study was to investigate correlation between use bacterial resistance Clinical Center Nis, one biggest hospitals Serbia.The data antibiotics were obtained from database Department Pharmacotherapy expressed as defined daily doses per 100 bed-days (DBD), during...

What is known and Objective: There little published information about antibiotic utilization resistance amongst hospital inpatients in Serbia. The purpose of this study was to analyse the variation relation between bacterial resistance. Methods: This analysis performed surgical clinic one biggest Serbian tertiary hospitals, during 2005–2008. Data on use antibiotics were obtained expressed as defined daily doses per 100 bed-days. Bacterial resistances given percentages resistant isolates....

SPE-HPLC method has been developed and validated for rapid analysis of carbamazepine its two metabolites epoxide trans-diol in human plasma. The was performed using C18 Bakerbond-BDC analytical column (250 mm x 4.6 i.d., particle size 5 ?m). optimal conditions the separation were established with mobile phase acetonitrile - 10 mM phosphate buffer, pH 7.0 (30:70, v/v) at flow rate 1.5 mL min-1, temperature 35?C, UV detection 210 nm. Total run time about 8 minutes. SPE procedure extraction...

The aim of the study was to evaluate parameters oxidative and nitrosative stress as well antioxidative in a group renal transplant recipients with stable graft function no clinical signs cardiovascular disease. We also aimed determine correlations among these potential differences all biomarkers regard immunosuppression protocol.We enrolled 57 31 controls who were age sex matched recipients. All patients included this had post-renal surgery at least 12 months earlier on standard...

Background: Renal transplant dysfunction has been shown to be independent predictor for premature cardiovascular disease and mortality. Renalase, a flavoprotein secreted by several tissues, including the kidney, found regulate sympathetic tone blood pressure. The purpose of this secondary analysis was explore relationships among parameters endothelial dysfunction, lipids, glomerular filtration rate, renalase in 2 groups: renal patients with controlled hypertension healthy volunteers....

Abstract: Monitoring of tacrolimus blood concentration is utmost importance in the management renal transplant recipients because Narrow Therapeutic Index and highly variable pharmacokinetics. The aim this study was to detect inter‐patient pharmacokinetic variability assess predictability individual concentrations at various times area under curve (AUC) seeking find best sampling time predict exposure with triple therapy. This oral dose pharmacokinetics conducted 18 Serbian on...

Immunosuppressive drugs play a crucial role in the inhibition of immune reaction and prevention graft rejection aswell as pharmacotherapy autoimmune disorders. Effective immunosuppression should provide an adequate safety profile improve treatment outcomes patients' quality life. High-risk transplant recipients may be identified, but definitive prediction model has still not been recognized. Therapeutic drug monitoring (TDM) for immunosuppressive is essential, at same time insufficient tool...

Abstract A 39-year-old female presented to the nephrology clinic emergency department with a complaint of muscle weakness and stomach pain. detailed personal history revealed ingestion 50–100 g herbal products which contained licorice, every day for 8 weeks treat sterility. The product was studied determined contain ‘licorice’ containing glycyrrhizic acid. Licorice (a plant contains acid) induced hypokalemia usually has mild progression. However, it may cause critical failure in physical...

Summary Decreased nitric oxide (NO) production and/or impaired NO bioavailability may occur in patients with the chronic kidney disease (CKD), and could contribute to elevation of blood pressure, cardiovascular (CVD) progression renal injury these patients. Free guanidinomethylated arginine residues endogenously as a result proteolysis post-translational methylated tissue proteins. The asymmetric dimethyl (ADMA) is competitive inhibitor synthase (NOS) enzymes. has predominant role ADMA...

We present a case which reports the occurrence of psychotic disorders after metronidazole and levofloxacin therapy in chronic kidney patient while being treated for enterocolitis urinary infection. A 48-year-old female was admitted to hospital placement peritoneal dialysis catheter due indicated dialysis. During admission, symptoms infection had occurred, so were introduced into therapy, respectively. After 4 days 3 became confused, disoriented, with signs delirium. Since diagnosis...

Background: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics exposure. Aim: This study aimed to assess validate the effect of Tac IPV trough concentration-to-dose ratio (C0/D) over 6-12 months on reduced estimated glomerular filtration rate (eGFR) values late period after kidney transplantation (Tx), applying Monte Carlo (MC) simulation. Methods: The previously published linear regression was basis for MC simulation, performed...

Self-medication represents the use of medicines and herbal remedies with purpose treating or preventing a disease symptoms which are recognized by patients themselves. Drugs that intended for self-medication do not require prescription called “over-the-counter medicines” (OTC) products. The aim paper was to evaluate in adult population Nis region determine potential factors affecting level quality self-medication. A total 300 respondents, divided into three age categories, were interviewed:...

The study aimed to estimate and compare the prevalence type of potentially inappropriate medications (PIMs) potential prescribing omissions (PPOs) between STOPP/START original (v1) updated version (v2) among older patients in various settings, as well associated factors. included 440 attending a community pharmacy, 200 outpatients 140 nursing home users. An increase STOPP v2 (57.9%) compared v1 (56.2%) was not statistically significant total sample within each setting (p>0.05). A decrease...