A5103145152- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Multiple and Secondary Primary Cancers
- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Intracerebral and Subarachnoid Hemorrhage Research
- Chemokine receptors and signaling
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Enhanced Recovery After Surgery
- Cerebrospinal fluid and hydrocephalus
- Abdominal vascular conditions and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
Sapporo Medical University
2024-2025
Kyoto University
2018-2024
Iwate Medical University
2001-2024
Nihon University
2006-2024
St. Marianna University School of Medicine
2021
Tenri Hospital
2016-2019
Shiga University of Medical Science
2003-2018
Shiga Medical Center
2018
Creative Research Enterprises (United States)
2018
Mitsubishi Kyoto Hospital
2016
Cytoplasmic male sterility (CMS) in plants is a maternally inherited inability to produce functional pollen, and often associated with mitochondrial DNA abnormalities. Specific nuclear loci that suppress CMS, termed as restorers of fertility (Rf), have been identified. Previously, we identified an Rf for the CMS Kosena radish used genetic analysis identify locus create contig covering critical interval. To gene, introduced each lambda cosmid clones into Brassica napus scored restoration....
Inflammatory angiogenesis is a critical process in tumor progression and other diseases. The inflammatory cytokine IL-1beta promotes angiogenesis, growth, metastasis, but its mechanisms remain unclear. We examined the association between IL-1beta-induced cell inflammation. induced neovascularization mouse cornea at rates comparable to those of VEGF. Neutrophil infiltration occurred on day 2. Macrophage days 4 6. anti-Gr-1 Ab-induced depletion infiltrating neutrophils did not affect IL-1beta-...
The coat protein (CP) gene of rice stripe virus was introduced into two japonica varieties by electroporation protoplasts. resultant transgenic plants expressed the CP at high levels (up to 0.5% total soluble protein) and exhibited a significant level resistance infection. Plants derived from selfed progeny primary transformants also showed viral resistance, indicating stable transmission trait next generation. Moreover, virally encoded strip disease-specific not detected in expressing 8...
Low-dose cisplatin and 5-fluorouracil (LDPF) chemotherapy with daily radiotherapy (RT) is used as an alternative chemoradiotherapy regimen for locally advanced esophageal carcinoma. We evaluated whether RT plus LDPF had advantage in terms of survival and/or toxicity over standard-dose (SDPF) this study. This multicenter trial included cancer patients clinical T4 disease unresectable regional lymph node metastasis. Patients were randomly assigned to receive (2 Gy/fraction, total dose 60 Gy)...
Attention has recently focused on the critical role of inflammatory responses in tumor stroma that provide favorable conditions for cancer‐cell growth and invasion/metastasis. In particular, macrophages recruited into activated, known as tumor‐associated macrophages, are suggested to promote tumorigenesis. this study, we examined effect a decrease number monocytes/macrophages peripheral blood development bone muscle metastases by lung cancer cells. Treatment with clodronate encapsulated...
The focus of the present study was whether and how infiltrating macrophages play a role in angiogenesis growth cancer cells response to inflammatory cytokine interleukin (IL)‐1β. Lewis lung carcinoma overexpressing IL‐1β grew faster induced greater neovascularization than low IL‐1β‐expressing counterpart vivo . When were depleted using clodronate liposomes, both tumor reduced tumors. Co‐cultivation with synergistically augmented migration vascular endothelial cells. In these co‐cultures,...
Cerebral amyloid angiopathy (CAA) is a disease in which beta (Aβ) deposited blood vessels and meninges the brain. typically occurs elderly but also known to occur younger patients with history of childhood head trauma or dura graft following neurosurgical procedures. The patient was 39-year-old female who had undergone neurosurgery for an arachnoid cyst right temporal lobe at age two years. Severe headache, dizziness, leg weakness developed abruptly. Aβ42/40 ratio decreased cerebrospinal...
OBJECTIVE Awake craniotomy is commonly used to resect lesions located near the language area during brain surgery. However, it often difficult perform tasks due several limitations such as difficulty in awakening surgery and intraoperative seizures. This study investigated clinical significance of bidirectional corticocortical evoked potential (CCEP) monitoring a new approach evaluate function. METHODS enrolled 12 patients who underwent awake tumor resection with CCEP assess Electrodes were...
Abstract Background The aim of this study was to investigate the possible prognostic factors and predictive accuracy Glasgow Prognostic Score (GPS) for patients with unresectable locally advanced esophageal squamous cell carcinoma (LAESCC) treated chemoradiotherapy. Methods One hundred forty-two were enrolled in JCOG0303 assigned standard cisplatin 5-fluorouracil (PF)-radiotherapy (RT) group or low-dose PF-RT group. thirty-one sufficient data included analysis. A Cox regression model used...
The objective of this study was to evaluate the therapeutic usefulness chemoradiotherapy (CRT) followed by surgery in patients with clinically T4 (cT4) esophageal cancer involving adjacent organs such as trachea, main bronchi, and large vessels. Thirty-seven cT4 squamous cell carcinoma thoracic esophagus were enrolled study. CRT regimen comprised cisplatin (70 mg/m2) on day 1, 5-fluorouracil (700 days 1–4 external irradiation (200 cGy/day, total 30 Gy) either 8–26 (sequential schedule, n=15)...
OBJECTIVE The purpose of this study was to understand the anatomical and functional connections between paracentral lobule (PCL) primary motor cortex (M1) human brain. METHODS This retrospective included 16 patients who underwent resection lesions located near M1. Nine had in dominant hemisphere. Tractography performed visualize connectivity two regions interest (ROIs)—the convexity interhemispheric fissure—that were shown by MRI be activated during a finger tapping task. number, mean...
Background and Aims: The mechanism underlying liver regeneration following partial hepatectomy (PH) is not fully elucidated. We aimed to characterize collagen gene expressing hepatic cells PH examine their contribution regeneration. Approach Results: Col‐GFP mice, which express GFP under the control of promoter, were used detect PH. GFP‐expressing analyzed via single‐cell RNA sequencing (scRNA‐seq). Additionally, Col‐ER Cre/RFP Cre/DTA mice utilized cell fates functional roles in...
The aim of the present study was to evaluate long-term outcomes laparoscopic Heller myotomy with Dor fundoplication (LHD) and its effect on chest pain. Between June 1995 August 2009, a total 35 patients achalasia underwent an LHD. symptom scores were calculated by combining frequency severity. Pre- postoperative evaluations included score, radiology, manometry, 24-hour pH manometry. Median score significantly lower than preoperative (19 vs 4, P < 0.001) at median follow-up 94 months. Among...
The aim of this study was to assess the feasibility and outcomes concomitant laparoscopic treatment for coexisting spleen gallbladder diseases.Between March 1997 August 2009, 9 patients underwent splenectomy cholecystectomy. Indications included hereditary spherocytosis (4 patients), splenic artery aneurysm (2), hypersplenism Evans syndrome (1).The median operating time blood loss were 165 minutes (range: 70 300 min) 36 mL 10 274 mL). resected weight 256 g 137 820 g). No patient required...
Autotaxin (ATX) is an extracellular lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine into lysophosphatidic acid (LPA). Recent accumulating evidence indicates biological roles ATX in malignant tumors. However, expression and clinical implications human cholangiocarcinoma (CCA) remain elusive.
Abstract Background and Purpose Elevated intracranial pressure (ICP) resulting from severe head injury or stroke poses a risk of secondary brain that requires neurosurgical intervention. However, currently available noninvasive monitoring techniques for predicting ICP are not sufficiently advanced. We aimed to develop minimally invasive prediction model using simple CT images prevent caused by elevated ICP. Methods used the following three methods determine presence absence midbrain‐level...
The body's response to stress is comprised of two opposing reactions, namely inflammation and immunosuppression. balance between these reactions not only changes over time, but also varies among different cells or organs. Limited information available regarding the cytokine circulating blood inflammatory sites after thoracic surgical stress.The subjects present study were 10 patients undergoing esophageal cancer surgery which requires thoracolaparotomic manipulation. postoperative levels...
Situs inversus is a rare congenital condition that currently classified into two types: complete situs (situs totalis, SIT) and partial partialis, SIP). In SIP patients, some organs are inverted others in their expected position, individual patient variation organ position increases surgical difficulty. Several surgeons have performed laparoscopic or robotic surgeries but almost all were SIT patients. We report the first case, to our knowledge, of an with gastric cancer who was successfully...