A5100458158- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Bone Metabolism and Diseases
- Biosensors and Analytical Detection
- Hydrology and Sediment Transport Processes
- Cancer-related gene regulation
- Pneumonia and Respiratory Infections
- RNA and protein synthesis mechanisms
- Magnetic and Electromagnetic Effects
- Genomics and Phylogenetic Studies
- Advanced NMR Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Geological formations and processes
- BRCA gene mutations in cancer
- Geology and Paleoclimatology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related Molecular Pathways
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Cell death mechanisms and regulation
- Bacterial Identification and Susceptibility Testing
- Wnt/β-catenin signaling in development and cancer
- Enterobacteriaceae and Cronobacter Research
China University of Petroleum, Beijing
2023
The University of Texas Health Science Center at San Antonio
2018
The University of Texas Health Science Center at Houston
2018
Xiangya Hospital Central South University
2018
Central South University
2018
University of Nebraska–Lincoln
2017
University of California, Davis
2014
National University of Singapore
2013
Nanjing Medical University
2013
Harvard University
2013
The recent identification of the genes responsible for several human genetic diseases affecting bone homeostasis and characterization mouse models these indicated that canonical Wnt signaling plays a critical role in control mass. Here, we report osteoblast-specific transcription factor Osterix (Osx), which is required osteoblast differentiation, inhibits pathway activity. First, calvarial cells embryonic day (E)18.5 Osx-null embryos, expression antagonist Dkk1 was abolished, target c-Myc...
Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated by chemoradiotherapy. However, the outcome has not improved significantly due to radioresistance of cancer cells. This study aimed determine radiosensitizing effect LCL161, a novel second mitochondrial-derived activator caspase (Smac) mimetic, in ESCC lines were with LCL161 or radiation, alone combination. Cell proliferation was detected MTT assay. Radiosensitization evaluated clonogenic survival apoptosis...
Objective: Ventricular infection from multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is one of the most severe complications craniotomy. However, availability effective therapeutic options for these infections limited. Thus, this report aims to describe efficacy abscess clearance by intraventricular and intravenous tigecycline therapy in managing patients with A. ventriculitis after neurosurgery. Moreover, current literature on use life-threatening reviewed summarized, a...
The applicability of sequence stratigraphic models to continental fluvial successions has long been topic for debate. To improve our understanding how architectures record responses changes in the ratio between accommodation rate and sediment-supply (A/S), two case studies are analyzed, including a densely drilled subsurface reservoir imaged with seismic cube, an outcropping succession. dataset provides larger, three-dimensional perspective, whereas outcrop enables observation at higher...
Abstract Variants that alter the DNA-binding specificity of transcription factors could affect for and expression potentially many target genes, as has been observed in several tumor-derived mutations. Here we examined if such trans quantitative trait loci (trans-eQTLs) similarly result from common genetic variants. We chose to focus on Cys2-His2 class zinc finger because they are most abundant superfamily human have well-characterized DNA binding interactions. identified 430 SNPs cause...
Germ-line mutations in breast cancer susceptibility gene, BRCA1, result familial predisposition to and ovarian cancers. The BRCA1 protein has multiple functional domains that interact with a variety of proteins cellular processes. Understanding the biological consequences interactions its binding partners is important for elucidating tissue-specific tumor suppression function. Cofactor (COBRA1) BRCA1-binding that, as component negative elongation factor (NELF), regulates RNA polymerase II...
Aminoacyl-tRNA synthetases (aaRSs) are part of the cellular translation machinery and as such, they essential enzymes for every known cell. Due to their ubiquitous nature, evolutionary history has been intensely researched better understand origins life on a molecular level. Herein, we examine relatedness leucyl-tRNA (LeuRS) from each major eukaryotic branch through speciation process. This research effort was centered amino acid sequence data well generating homology protein models LeuRS...
Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation from mesenchymal stem cells.In Osx-null mice, no occurs.Matrix metalloproteinase 13 (MMP13) a member of the matrix family plays important role in endochondral ossification remodeling.Transcriptional regulation MMP13 expression osteoblasts not well understood.Here, we provide several lines evidence which show that direct target Osx osteoblasts.Calvaria obtained embryos...
Abstract Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it unclear whether loss these ubiquitously important fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate elimination R-loops, DNA-RNA hybrid structures involved transcription genetic instability. Here we show that R-loops accumulate...