A5057390834- Renal Diseases and Glomerulopathies
- Control Systems and Identification
- Advanced Control Systems Optimization
- Stability and Control of Uncertain Systems
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Kidney Disease and Diabetes
- Non-Invasive Vital Sign Monitoring
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Evacuation and Crowd Dynamics
- Natural Products and Biological Research
- Vasculitis and related conditions
- Pharmacological Effects of Natural Compounds
- Hemophilia Treatment and Research
- Systemic Sclerosis and Related Diseases
- Hemodynamic Monitoring and Therapy
- Fault Detection and Control Systems
- Advanced Control Systems Design
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Drug-Induced Hepatotoxicity and Protection
- Redox biology and oxidative stress
- Dialysis and Renal Disease Management
- Facility Location and Emergency Management
Hyogo Prefectural Amagasaki General Medical Center
2020-2025
Shimada Municipal Hospital
2009-2024
Hiroshima City University
2013-2022
International University Of Health And Welfare Atami Hospital
2012-2021
Nagoya City University
2012-2019
Toho University
2017
Toho University Ohashi Medical Center
2017
International University of Health and Welfare
2013-2016
Hiroshima University
2014
University of Shizuoka
2004-2012
Rosmarinic acid is a phenolic compound widely distributed in Labiatae herbs such as rosemary, sweet basil, and perilla, which are frequently used with meat fish dishes Western Asian countries. In the present study we investigated effects of rosmarinic on cultured murine mesangial cell proliferation.Cultured cells were stimulated by growth factors or without acid, [(3)H]thymidine incorporation was measured regard both to signal transduction cycle dependency. other experiments, mRNA extracted...
<i>Background:</i> To determinewhether intravenous immunoglobulin (IVIg) cancontrol disease activity in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated rapidly progressive glomerulonephritis (RPGN). <i>Methods:</i> Twelve serologically and histologically confirmed MPO-ANCA-associated RPGN (7 men, 5 women; mean age 71 ± 3 years) received IVIg (400 mg/kg/day) alone for days. The effects of were evaluated by white blood cell...
Oxidative stress is a major determinant of acute kidney injury (AKI); however, the effects an AKI on renal redox system are unclear, and few existing markers suitable for evaluating oxidative stress. We measured urinary levels redox-regulatory protein thioredoxin 1 (TRX1) in patients with various kinds disease mice ischemia-reperfusion injury. Urinary TRX1 were markedly higher than those chronic or healthy subjects. In receiver operating characteristic curve analysis to differentiate between...
Rosmarinic acid is known to be a natural phenolic compound widely distributed in Labiatae herbs such as rosemary, sweet basil, and perilla. In the present study, we evaluated suppressive effects of rosmarinic on mesangioproliferative glomerulonephritis vivo, which was induced by intravenous injection rabbit anti-rat thymocyte serum (ATS) rats.Rosmarinic orally administered rats at dose 100 mg/kg/day from day ATS (day 0) 8 when were sacrificed. The degree mesangial cell proliferation matrix...
The active type of coagulation factor X (factor Xa) activates various cell-types through protease-activated receptor 2 (PAR2). We previously reported that a Xa inhibitor could suppress Thy-1 nephritis. Considering fibrin deposition is observed in diabetic nephropathy as well glomerulonephritis, this study examined the roles pathway and development using model mice. Diabetic (db/db) normoglycemic (m+/m+) mice were immunohistochemically evaluated for their expression/deposition PAR2,...
The inhibitory effects of Perilla frutescens and its phenolic constituents on cytokine-induced proliferation murine cultured mesangial cells were investigated. DNA synthesis stimulated by platelet derived growth factor (PDCF, 10ng/ml) or tumor necrosis (TNF)-α (lOO U/ml) was inhibited the extract P. (IC50 values, 3.3 1.4 µg/ml, respectively). strength anti-proliferative activity nearly equal in various chemotypes frutescens. Caffeic acid, methyl caffeate, rosmarinic luteolin...
For 30 myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) related rapidly progressive glomerulonephritis patients (male 17, female 13, average age of 68 +/- 11.8 years old), intravenous immunoglobulin (IVIg) (400 mg/kg/day) was administered for 5 consecutive days before or along with conventional immunosuppressive therapy in Japan. Twenty were treated IVIg the start newly increase and evaluated independent effect this therapy. In these patients, just after IVIg, significant...
Background. Myeloperoxidase-specific anti-neutrophil cytoplasmic auto-antibody (MPO-ANCA) has been a useful diagnostic marker in systemic vasculitis with crescentic glomerulonephritis (CrGN). It is highly suspected that the antigenic enzyme MPO released from activated neutrophils involved these lesions. We evaluated relationship between neutrophil functions including peripheral counts and renal lesions SCG/Kj mice as model of ANCA-associated CrGN vasculitis.
It is well known that tissue factor starts the extrinsic coagulation pathway, which activates X to Xa, and V a membrane-bound potent cofactor for terminating stage of prothrombin activation by Xa. In previous in vitro study, was induced cultured mesangial cells inflammatory stimulation increased expression promoted fibrin generation on cell surface. We report extracellular matrix (ECM) accumulation association with area through mesangioproliferative glomerulonephritis (MsPGN). Wistar rats...
The leaves of Perilla frutescens (perilla) are a common herb used in Japan for garnishing raw seafood. Previously, we reported that decoction perilla had suppressive effects on the progression glomerulonephritis an animal model spontaneous IgA nephropathy. objective present study was to isolate anti-nephritic constituents under guidance its vitro anti-proliferative activity cultured murine mesangial cells, and measure contents active decoctions prepared from various chemotypes, which differ...
The effects of perilla (Perilla frutescens, Labiatae) on murine cultured vascular smooth muscle cells (VSMC) were investigated. water extract leaves induced nitric oxide (NO) production VSMC and this effect was synergistically augmented when combined with interferon (IFN)-gamma or tumour necrosis factor (TNF)-alpha, while the significantly inhibited NO by IFN-gamma lipopolysaccharide (LPS). Northern blot analysis revealed that these paralleled mRNA expression inducible synthase. However,...