A5082420619- Ocular Surface and Contact Lens
- Signaling Pathways in Disease
- Advancements in Transdermal Drug Delivery
- Ion Channels and Receptors
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Connexins and lens biology
- Microencapsulation and Drying Processes
- Histone Deacetylase Inhibitors Research
- Biochemical effects in animals
- Olfactory and Sensory Function Studies
- Essential Oils and Antimicrobial Activity
- Circadian rhythm and melatonin
- Natural Antidiabetic Agents Studies
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- Seed and Plant Biochemistry
- Immune Response and Inflammation
- Biochemical Acid Research Studies
Consejo Superior de Investigaciones Científicas
2022-2023
Instituto de Neurociencias
2017-2023
Instituto de investigación sanitaria y biomédica de Alicante
2023
EU Business School
2022
Neurotech (United States)
2022
Hospital Universitari Sant Joan D'Alacant
2021
Universitat de Miguel Hernández d'Elx
2018-2019
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5, and 7 but not Hdac9. Here, we show that a transcription factor regulated genetic compensatory mechanism within family proteins, blocks negative regulators myelination ensuring peripheral nerve developmental remyelination after injury. Thus, when Hdac4 5 are knocked-out from mice, JUN-dependent induces overexpression Hdac7 permitting, although...
Cyclosporine A (CsA) is used for the treatment of dry eye (DE) with good clinical results, improving tear secretion and decreasing subjective symptoms. These effects are attributed to improved film dynamics, but there no data on effect CsA abnormal sensory nerve activity characteristic in DE. Our purpose was evaluate enhanced corneal cold thermoreceptors a tear-deficient DE animal model using vitro extracellular recording terminal impulses (NTIs) before presence CsA. NTI shape also analyzed....
The role of TRPA1 in the thermosensitivity corneal cold thermoreceptor nerve endings was studied young and aged mice. contribution TRPA1-dependent activity to basal tearing thermally-evoked blink also explored. thermoreceptors’ recorded extracellularly (5-month-old) (18-month-old) C57BL/6WT (WT) TRPA1−/− knockout (TRPA1-KO) mice at temperature (34 °C) during cooling (15 heating (45 ramps. response heat stimulation ocular surface rate were measured animals using orbicularis oculi muscle...
Purpose TRPA 1 and TRPM 8 channels provide cold sensitivity to thermoreceptor neurons, being activated by high‐ low‐intensity cooling stimuli respectively. Corneal sensory nerve terminals ( CSNT s) encode both corneal surface temperature reductions tear osmolarity increases associated with evaporation, acting as `dryness detectors′. 8‐dependent activity of s contribute basal tearing is disturbed ageing, while the role 1‐dependent still unknown. In present work, electrical from 1‐ KO mice was...
Abstract Purpose To determine the influence of dendritic cells (DCs) in modulating corneal sensory nerve activity at basal conditions using a DC‐depletion mice model. Methods C57BL/6 CD11c‐DTR (5‐6 month old) both sexes were used. The effect short‐term (2 days) and long‐term (8 DC depletion on was studied eyes following bilateral temporal nasal subconjunctival injections diphtheria toxin (DT) anesthetized animals. Nerve terminal impulse (NTI) cold thermoreceptor endings recorded excised...
Abstract Purpose: CD11c‐DTR+ mice have a transgene encoding for simian diphtheria toxin (DT) receptor under the CD11c promoter that makes dendritic cells (DCs) sensitive to DT, which causes DC depletion. Preliminary results using this mouse suggest there is functional interaction between DCs and corneal sensory nerves, as depletion modifies nerve activity nociceptive behaviour. The aim of work was validate model proving observed effects are not due DT itself, littermates negative therefore...
ABSTRACT The class IIa histone-deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express HDAC4, 5 and 7 but not HDCA9. Here we show that a transcription factor regulated genetic compensatory mechanism within family proteins, blocks negative regulators myelination ensuring peripheral nerve developmental remyelination after injury. Thus, when HDAC4 are knocked-out from cells, c-Jun dependent induces overexpression HDAC7 permitting,...