A5030952768- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Palliative Care and End-of-Life Issues
- Thyroid and Parathyroid Surgery
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Inflammation biomarkers and pathways
- Lung Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Cardiac Health and Mental Health
- Chemotherapy-related skin toxicity
- Myasthenia Gravis and Thymoma
- Neurological Disease Mechanisms and Treatments
- Occupational and environmental lung diseases
- Teratomas and Epidermoid Cysts
- Frailty in Older Adults
- Pleural and Pulmonary Diseases
- Intensive Care Unit Cognitive Disorders
- Potassium and Related Disorders
- Genetic factors in colorectal cancer
The University of Texas Health Science Center at Houston
2018-2025
The University of Texas MD Anderson Cancer Center
2020
Background Patients with advanced cancers visit the emergency room and get hospitalised frequently, potentially half of these visits being avoidable. Our institution provides comprehensive, low-cost cancer treatment to a safety-net population in Texas. We performed retrospective review hospital readmission patterns amongst our oncology patients developed posthospitalisation workflow reduce readmissions. Method Following discharge, were risk stratified based on their Length stay, Acuity...
Coronary atherosclerosis and recurrent cardiovascular events are common among individuals with type 2 myocardial infarction (T2MI). However, resource utilization T2MI patients is unclear. The aim of the study was to characterize across United States. Using Optum's de-identified Clinformatics Data Mart Database, procedures, physician services, prescriptions within 6 months postdischarge were compared vs 1 (T1MI) between October 1, 2017, June 30, 2020. Multivariable logistic regression...
Background and Purpose: CD200 (cluster of differentiation 200), a highly glycosylated protein primarily expressed on neurons in the central nervous system, binds with its receptor CD200R to form an endogenous inhibitory signal against immune responses. However, little is known about effect neuronal signaling cerebral ischemia. The aim this study was investigate how impacts poststroke inflammation ischemic injury. Methods: tma1 lf/fl :Thy1CreER mice were treated tamoxifen induce conditional...
The microbiome is pivotal in maintaining health and influencing disease by modulating essential inflammatory immune responses. Hepatocellular carcinoma (HCC), ranking as the third most common cause of cancer-related fatalities globally, influenced gut through bidirectional interactions between liver, evidenced both mouse models human studies. Consequently, biomarkers based on microbiota represent promising non-invasive tools for early detection HCC. There a growing body evidence suggesting...
To investigate the utility of a novel serum miRNA biomarker panel to distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
Abstract Background Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) an attractive potential treatment. However, TKIs have been associated with increased risk tumor cavitation, in turn linked poor outcomes, patients lungs, where thyroid cancer commonly metastasizes. Method We performe d a retrospective cohort study and evidence metastatic disease lung that were treated...
Introduction: Circulating inflammatory cytokines play critical roles in tumor-associated inflammation and immune responses. Recent data have suggested that several interleukins (ILs) mediate carcinogenesis hepatocellular carcinoma (HCC). However, the predictive prognostic value of circulating ILs is yet to be validated. Our study aimed evaluate association serum with overall survival (OS) clinicopathologic features a large cohort HCC patients. Methods: We prospectively collected samples from...
Introduction:In this study, we explored the potential of plasma growth hormone (GH) as a prognostic biomarker in patients with advanced HCC treated durvalumab plus tremelimumab (D+T).Methods: In included 16 who received D+T at MD Anderson Cancer Center between 2022 and 2023 had GH measurements recorded before treatment.Plasma levels were measured from prospectively collected blood samples correlated progression-free survival (PFS) overall (OS).The cutoff for normal women men was defined ≤3.7...
e16161 Background: In this study, we explored the potential of plasma growth hormone (GH) as a prognostic biomarker in patients with advanced HCC treated durvalumab plus tremelimumab (D+T). Methods: included 24 who received D+T at MD Anderson Cancer Center between 2022 and 2023. Plasma GH levels were measured from prospectively collected blood samples 16 correlated progression-free survival (PFS) overall (OS). The cutoff for normal women men was defined ≤3.7 μg/L ≤0.9 μg/L, respectively....
Abstract Background: Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) an attractive potential treatment. However, TKIs have been associated with increased risk tumor cavitation, in turn linked poor outcomes, patients lungs, where thyroid cancer commonly metastasizes. Method: We performed a retrospective cohort study and evidence metastatic disease lung that were treated...
Abstract Background and Objectives Precision medicine has altered the management of colorectal cancer (CRC). However, concordance mutational findings between primary CRC tumors associated pulmonary metastases (PM) is not well‐described. This study aims to determine genomic profiles PM. Methods Patients treated for PM at a single institution from 2000 2017 were identified. Mutational was defined as either both wild‐type or mutant alleles in lung lesion; genes with opposing reported...
56 Background: Patients with cancer visit the emergency room (ER) and are hospitalized frequently. Contributing factors may include uncontrolled symptoms (cancer- or treatment-related), caregiver fatigue, concerns about cancer, difficulty accessing healthcare elsewhere. It is estimated that nearly 50% of ER hospital visits by advanced patients be avoidable. This represent unmet needs in oncology outpatient care counseling. The LACE+ index a validated clinical tool available within EPIC...
Introduction: The Inflammatory response is a fundamental pathophysiological procedure in stroke, and the activation of microglia characterized by either M1 (pro-inflammatory) or M2 (anti-inflammatory) state crucial initiating, sustaining resolving post-stroke inflammation. IRF5/4 are key determinants macrophage polarization. Our previous study has also shown signaling corresponds to microglial M1/M2 early/late phases ischemic stroke respectively. In present study, we tested our hypothesis...
Thymomas are slow-growing neoplasia arising from the epithelial cells of thymus that usually present with respiratory symptoms, superior vena cava syndrome, or parathymic syndromes. Approximately 30% thymomas develop myasthenia gravis. An additional 5% patients have other systemic syndromes, including rheumatoid arthritis, thyroiditis, red cell aplasia, lupus erythematosus, and Cushing syndrome. Rarely, can diarrhea due to thymoma-associated autoimmune gastrointestinal pathologies include...
Abstract Background: Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) an attractive potential treatment. However, TKIs have been associated with increased risk tumor cavitation, in turn linked poor outcomes, patients lungs, where thyroid cancer commonly metastasizes. Method: We performed a retrospective cohort study and evidence metastatic disease lung that were treated...
Abstract Background: Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) an attractive potential treatment. However, TKIs have been associated with increased risk tumor cavitation, in turn linked poor outcomes, patients lungs, where thyroid cancer commonly metastasizes. Method: We performed a retrospective cohort study and evidence metastatic disease lung who were treated...
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of various advanced malignancies. By unleashing immune system from its natural self-autoregulating mechanisms, malignant cells throughout body are more effectively destroyed. These new immunotherapies been used for a variety cancers including cancer lung, colon, skin, prostate, and more. Although these therapies provide an effective mechanism at treating cancer, they unfortunately come with undesirable autoimmune side...
Introduction: Delirium is an acute confusional state typically seen in patients admitted to the hospital that can affect mentation, cause agitation, and complicate inpatient stays. The number of older adults with cardiovascular diseases rapidly increasing. When hospital, elderly are at increased risk developing delirium. Hypothesis: We hypothesized there will be predictors associated delirium among who were hospitalized care units disease. Methods: A retrospective chart review was conducted...