A5022357001- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Growth Hormone and Insulin-like Growth Factors
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Nutritional Studies and Diet
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Neutropenia and Cancer Infections
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sulfur Compounds in Biology
- Liver physiology and pathology
- Opioid Use Disorder Treatment
- HIV, Drug Use, Sexual Risk
- Pain Management and Opioid Use
- Lipid metabolism and disorders
- Radiation Therapy and Dosimetry
- Viral-associated cancers and disorders
- Lung Cancer Diagnosis and Treatment
- 14-3-3 protein interactions
The University of Texas MD Anderson Cancer Center
2019-2025
Centers for Disease Control and Prevention
2015
Hepatocellular carcinoma (HCC) disproportionately affects Hispanic persons with higher age-specific incidence and increased mortality rates compared to non-Hispanic Whites. These high of may be explained by the variation in risk factors. Given prevalence type 2 diabetes mellitus (DM) among population, we aimed assess prognosis HCC Mexican Americans DM consideration treatment for DM. A case-control study 241 American patients 500 healthy controls Texas was conducted. Multivariable logistic...
Six strategies for identifying hepatitis C virus (HCV) viremia, involving testing HCV antibody (HCVAb) followed by a nucleic acid test (NAT) RNA when the is positive, are compared. Decision analysis was used to determine mean relative cost per person tested and outcomes of viremia detection. Parameters included proportions population with HCVAb plus specificity, sensitivity, individual tests. For an seroprevalence 3.25%, all adopting quantitative NAT vary little in (range, $29.50‐$30.70)...
// Yehia I. Mohamed 1 , Dan G. Duda 2 Muhammad O. Awiwi 3 Sunyoung S. Lee Lina Altameemi 4 Lianchun Xiao 5 Jeffrey Morris 6 Robert A. Wolff Khaled M. Elsayes Rikita Hatia 7 Aliya Qayyum Shadi Chamseddine Asif Rashid 8 James C. Yao Armeen Mahvash 9 Manal Hassan Hesham Amin 10 and Ahmed Omar Kaseb Department of Gastrointestinal Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, TX 77030, USA Steele Laboratories, Radiation Massachusetts General Hospital Harvard School,...
Adrenocortical carcinoma (ACC) is a rare malignancy whose risk factors are unclear. We explored the association of ACC with exposure to selected environmental factors, focus on cigarette smoking. conducted hospital‐based case–control study at The University Texas MD Anderson Cancer Center. Cases ( n = 432) patients treated Anderson, and controls 1,204) were healthy genetically unrelated spouses who had cancers not associated Information subjects’ demographic features was collected using...
Background and Aims N-nitroso compounds (NOCs) are among the most potent dietary carcinogens. N-nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), N-nitrosopiperidine (NPIP) abundant in foods carcinogenic to liver. We investigated relationship between NOCs HCC risk. Approach Results In this large, hospital-based, case-control study of 827 pathologically or radiologically confirmed cases 1,013 controls, NOC intake was calculated by linking food frequency questionnaire–derived data...
Abstract Background and Aims The role of dietary fat consumption in the etiology hepatocellular carcinoma (HCC) remains unclear. We investigated associations total fatty acids with risk HCC among US adults a hospital‐based case–control study. Methods analyzed data from 641 cases 1034 controls recruited at MD Anderson Cancer Center during 2001–2018. Cases were new patients pathologically or radiologically confirmed diagnosis HCC; cancer‐free spouses cancers other than gastrointestinal, lung,...
Immune checkpoint inhibitors (ICIs), agents that stimulate T-cell function, have become the standard first-line treatment for unresectable hepatocellular carcinoma (HCC). However, they may also cause immune-related adverse events (irAEs), which are rare and not been extensively reported. Here, we describe a case of severe febrile neutropenia pancytopenia after atezolizumab plus bevacizumab (atezo/bev) therapy its course.
Galectin-3 plays critical roles in the adhesion, proliferation, and differentiation of tumor cells. Recent data have suggested that galectin-3 a role development hepatocellular carcinoma (HCC); however, its prognostic value has not been validated. The aim our study was to evaluate clinical patients with HCC.
Abstract Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development the setting of metabolic perturbations. Using human samples, we investigated associations between common rare variants these closely related biochemical pathways risk for HCC a multicenter international study. We performed targeted exome sequencing 64 among 556 cases 643 cancer-free controls with conditions. Multivariable logistic regression was used to calculate...
The extent of provider-to-patient hepatitis C virus (HCV) transmission from diversion, self-injection, and substitution ("tampering") anesthetic opioids is unknown. To quantify the contribution opioid tampering to nosocomial HCV outbreaks, data health care-related outbreaks occurring in developed countries 1990 2012 were collated, grouped, compared. Tampering was associated with 17% (8 46) but 53% (438 833) cases. Of six (75%) involved fentanyl, five (63%) occurred United States, one each...
The objective of this study was to assess the association between dietary patterns and risk hepatocellular carcinoma (HCC) among US adults in a hospital-based case-control study. We analyzed data from 641 cases 1002 controls recruited at University Texas MD Anderson Cancer Center during 2001–2018. Cases were patients with pathologically or radiologically confirmed new diagnosis HCC; cancer-free spouses cancers other than gastrointestinal, lung, liver, head neck cancer. frequency-matched by...
Introduction: Circulating inflammatory cytokines play critical roles in tumor-associated inflammation and immune responses. Recent data have suggested that several interleukins (ILs) mediate carcinogenesis hepatocellular carcinoma (HCC). However, the predictive prognostic value of circulating ILs is yet to be validated. Our study aimed evaluate association serum with overall survival (OS) clinicopathologic features a large cohort HCC patients. Methods: We prospectively collected samples from...
Introduction:In this study, we explored the potential of plasma growth hormone (GH) as a prognostic biomarker in patients with advanced HCC treated durvalumab plus tremelimumab (D+T).Methods: In included 16 who received D+T at MD Anderson Cancer Center between 2022 and 2023 had GH measurements recorded before treatment.Plasma levels were measured from prospectively collected blood samples correlated progression-free survival (PFS) overall (OS).The cutoff for normal women men was defined ≤3.7...
e16161 Background: In this study, we explored the potential of plasma growth hormone (GH) as a prognostic biomarker in patients with advanced HCC treated durvalumab plus tremelimumab (D+T). Methods: included 24 who received D+T at MD Anderson Cancer Center between 2022 and 2023. Plasma GH levels were measured from prospectively collected blood samples 16 correlated progression-free survival (PFS) overall (OS). The cutoff for normal women men was defined ≤3.7 μg/L ≤0.9 μg/L, respectively....
Abstract Background: It is estimated that 6% to 20% of all cholangiocarcinoma (CCA) diagnoses are explained by primary sclerosing cholangitis (PSC), but the underlying risk factors in absence PSC unclear. We examined associations different with intrahepatic (ICC) and extrahepatic (ECC) United States. Methods: conducted a case–control study 121 patients ECC 308 ICC treated at MD Anderson Cancer Center between May 2014 March 2020, compared 1,061 healthy controls. Multivariable logistic...
e16660 Background: Sorafenib is the first systemic therapy approved for advanced HCC treatment; with no accurate tool available to help predict survival and treatment outcome guide decisions. Our novel blood-based insulin-like growth factor-1 (IGF)-Child-Turcotte-Pugh (CTP) score comprises levels of IGF-1, bilirubin, INR, albumin. IGF-CP significantly improved prediction in our recently published studies. The current prospective study aimed compare overall (OS) progression free (PFS) 116...
227 Background: The association between the GH/IGF-1 axis and HCC was reported in patients (pt) with underlying cirrhosis. However, there is limited information among pt without (w/o) We herein investigated role of GH as a circulating biomarker for diagnosis prognosis w/o Methods: Under IRB approval, we prospectively enrolled 1267 newly-diagnosed case control study at MD Anderson Cancer Center (2000-2015). Controls were healthy individuals (n = 1104). Plasma AFP measured 274 cirrhosis 200...
193 Background: Circulating insulin-like growth factor-1 (IGF-1) significantly declines in patients (pts) with cirrhosis and hepatocellular carcinoma (HCC), reflecting damaged hepatocytes. The bioavailability of IGF-1 is controlled by factor binding proteins (IGFBPs), which bind IGF-1. IGFBPs transcription cell specific, are secreted mainly the liver. Variations circulating HCC pts, especially those non-cirrhotic HCC, has not been elucidated. We investigated expression these without...
Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary cancer of liver with a five-year survival rate less than 5 percent. Gallbladder disease (GBD) defined as presence cholelithiasis or cholecystitis. Both and cholecystitis have been reported risk factors in development gastrointestinal cancers, such biliary tract pancreatic cancers. Moreover, patients GBD tend to develop chronic diseases, which may progress cirrhosis. However, role non-cirrhotic related HCC has not...
BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary cancer of liver with a five-year survival rate less than 5 percent. Gallbladder disease (GBD) defined as presence cholelithiasis or cholecystitis. Both and cholecystitis have been reported risk factors in development gastrointestinal cancers, such biliary tract pancreatic cancers. Moreover, patients GBD tend to develop chronic diseases, which may progress cirrhosis. However, role non-cirrhotic related HCC has not...