A5101522473- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Urinary Tract Infections Management
- Pregnancy and Medication Impact
- Reproductive tract infections research
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Influenza Virus Research Studies
- Maternal and Perinatal Health Interventions
- Streptococcal Infections and Treatments
- Neonatal Respiratory Health Research
- Reproductive Physiology in Livestock
- Vaccine Coverage and Hesitancy
- Surgical site infection prevention
- Gestational Diabetes Research and Management
- Rabbits: Nutrition, Reproduction, Health
- COVID-19 Impact on Reproduction
- Antibiotic Use and Resistance
- Neonatal and fetal brain pathology
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Pain Management
- Cardiovascular Issues in Pregnancy
- Genital Health and Disease
Stanford University
2017-2023
University of Colorado Denver
1994-2014
Novartis (United States)
2012
National Jewish Health
2010
University of Maryland, Baltimore
2007
University of Colorado Health
1995-2006
Denver School of Nursing
1991-1996
The University of Texas Health Science Center at San Antonio
1979-1994
Harvard University
1994
University of California, San Francisco
1994
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an clock in women delivering at term. Using mass cytometry, the abundance and functional responses all major cell subsets were quantified serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from elastic net algorithm, was developed to infer prospectively validate predictive...
Multiple biological clocks govern a healthy pregnancy. These mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of Modeling chronology these full-term pregnancy provides frameworks for future studies examining deviations implicated in pregnancy-related pathologies including preterm birth preeclampsia.
Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology.
Journal Article Intraamniotic Infection in Low-Hirth-Weight Infants Get access Rhoda S. Sperling, Sperling From the Department of Obstetrics and Gynecology, The University Texas Health Science Center at San Antonio, Antionio, Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward Newton, Newton Ronald Gibbs Please address requests reprints to Dr. Gibbs, Jane Roland Blumberg Professor, 7703 Floyd Curl Drive, 78284-7836. Infectious Diseases, Volume 157, Issue 1,...
The safety and immunogenicity of inactivated influenza virus vaccines in pregnant women have not been adequately investigated. In this study, 56 received A/New Jersey/76 vaccine during the second third trimesters pregnancy. No significant immediate reactions or increased fetal complications were associated with administration vaccine. antibody response to was similar that nonpregnant adults. Forty mother-infant pairs available for surveillance. At delivery, reciprocal titers greater than...
Preeclampsia is one of the most severe pregnancy complications and a leading cause maternal death. However, early diagnosis preeclampsia remains clinical challenge. Alterations in normal immune adaptations necessary for maintenance healthy are central features preeclampsia. prior analyses primarily focused on static assessment select cell subsets have provided limited information prediction Here, we used high-dimensional mass cytometry immunoassay to characterize dynamic changes over 370...
<h3>Importance</h3> Worldwide, preterm birth (PTB) is the single largest cause of deaths in perinatal and neonatal period associated with increased morbidity young children. The PTB multifactorial, development generalizable biological models may enable early detection guide therapeutic studies. <h3>Objective</h3> To investigate ability transcriptomics proteomics profiling plasma metabolomics analysis urine to identify measurements PTB. <h3>Design, Setting, Participants</h3> This...
To estimate whether elevations of complement C3a early in pregnancy are predictive the subsequent development adverse outcomes.A plasma sample was obtained from each enrolled pregnant woman before 20 weeks gestation. The cohort (n=1,002) evaluated for outcomes defined as hypertensive diseases (gestational hypertension or preeclampsia), preterm birth (before 37 gestation), premature rupture membranes, loss (during embryonic and fetal period), intrauterine growth restriction, composite outcome...
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling multivariate modeling to investigate biological signatures these characteristics. Maternal covariates were collected during pregnancy from 13,841 pregnant women across five sites. Plasma samples 231...
Early identification of pregnant women at risk for preeclampsia (PE) is important, as it will enable targeted interventions ahead clinical manifestations. The quantitative analyses plasma proteins feature prominently among molecular approaches used prediction. However, derivation protein signatures sufficient predictive power has been challenging. recent availability platforms simultaneously assessing over 1000 offers broad examinations the proteome, which may extraction proteomic with...
We evaluated moxalactam in 62 patients with puerperal or postabortal genital infections. In all patients, the initial dose was 6 g/day. 84% of we found anaerobes specimens. Of aerobic isolates, only enterococci were resistant. Among tested, two isolates (a Clostridium leptum and a Bacteroides disiens) had minimal inhibitory concentrations greater than equal to microgram/ml. Good clinical responses occurred 56 (90%). Moxalactam well tolerated little local irritation hepatic, renal,...
With the emergence of H1N1 pandemic (pH1N1) influenza, CDC recommended that pregnant women be one five initial target groups to receive 2009 monovalent vaccine, regardless prior infection with this influenza strain. We sought compare immune response versus vaccination and determine extent passive immunity conferred newborn.
GIBBS, RONALD S. MD; HALL, ROBERT T. YOW, MARTHA D. MCCRACKEN, GEORGE H. JR. NELSON, JOHN MD Author Information
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of Tin with SilicomolybdateIrvin. Baker, Martin. Miller, and R Stevens. GibbsCite this: Ind. Eng. Chem. Anal. Ed. 1944, 16, 4, 269–271Publication Date (Print):April 1, 1944Publication History Published online1 May 2002Published inissue 1 April 1944https://pubs.acs.org/doi/10.1021/i560128a012https://doi.org/10.1021/i560128a012research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations7LEARN...