Usha Dhingra
A5044308581- Child Nutrition and Water Access
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Neonatal skin health care
- Infant Nutrition and Health
- Autopsy Techniques and Outcomes
- Global Maternal and Child Health
- Pediatric health and respiratory diseases
- Preterm Birth and Chorioamnionitis
- Iron Metabolism and Disorders
- Pregnancy and Medication Impact
- Cardiac, Anesthesia and Surgical Outcomes
- Gestational Diabetes Research and Management
- Hemodynamic Monitoring and Therapy
- Child Nutrition and Feeding Issues
- Anesthesia and Sedative Agents
- Maternal and fetal healthcare
- Clostridium difficile and Clostridium perfringens research
- Metabolism and Genetic Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Folate and B Vitamins Research
- Gut microbiota and health
The Centre for Health (New Zealand)
2019-2024
Johns Hopkins University
2007-2023
Center for Disease Dynamics, Economics and Policy
2019-2022
Public Health Laboratory Ivo de Carneri
2017
Annamalai University
2001-2007
Office of International Affairs
2004
All India Institute of Medical Sciences
1994
Harvard University
1985-1990
Brigham and Women's Hospital
1985-1990
Hahnemann University Hospital
1987
Modelled mortality estimates have been useful for health programmes in low-income and middle-income countries. However, these are often based on sparse low-quality data. We aimed to generate high quality data about the burden, timing, causes of maternal deaths, stillbirths, neonatal deaths south Asia sub-Saharan Africa.In this prospective cohort study done 11 community-based research sites Africa, between July, 2012, February, 2016, we conducted population-based surveillance women...
Background. Low birth weight infants have been noted to low zinc concentrations in cord blood, and deficiency childhood is associated with reduced immunocompetence increased infectious disease morbidity. This study investigates whether supplementation of born full term small for gestational age affects mortality. Methods. A randomized, double-blind, controlled trial 2-by-2 factorial design enrolled 1154 full-term receive syrup 1 the following: riboflavin; riboflavin (5 mg as sulfate);...
Verbal autopsy methods are critically important for evaluating the leading causes of death in populations without adequate vital registration systems. With a myriad analytical and data collection approaches, it is essential to create high quality validation dataset from different evaluate comparative method performance make recommendations future verbal implementation. This study was undertaken compile set strictly defined gold standard deaths which autopsies were collected validate accuracy...
Monitoring progress with disease and injury reduction in many populations will require widespread use of verbal autopsy (VA). Multiple methods have been developed for assigning cause death from a VA but their application is restricted by uncertainty about reliability.
Reliable data on the distribution of causes death (COD) in a population are fundamental to good public health practice. In absence comprehensive medical certification deaths, only feasible way collect essential mortality is verbal autopsy (VA). The Tariff Method was developed by Population Health Metrics Research Consortium (PHMRC) ascertain COD from VA information. Given its potential for improving information about COD, there interest refining method. We describe further development...
<h3>Importance</h3> Worldwide, preterm birth (PTB) is the single largest cause of deaths in perinatal and neonatal period associated with increased morbidity young children. The PTB multifactorial, development generalizable biological models may enable early detection guide therapeutic studies. <h3>Objective</h3> To investigate ability transcriptomics proteomics profiling plasma metabolomics analysis urine to identify measurements PTB. <h3>Design, Setting, Participants</h3> This...
Recent reviews suggest common infectious diseases continue to be a major cause of death among preschool children in developing countries. Identification feasible strategies combat this disease burden is an important public health need. We evaluated the efficacy adding prebiotic oligosaccharide and probiotic Bifidobacterium lactis HN019 milk, preventing diarrhea, respiratory infections severe illnesses, aged 1-4 years as part four group study design, running two studies simultaneously.In...
Background Multiple micronutrient deficiencies are highly prevalent among preschool children and often lead to anemia growth faltering. Given the limited success of supplementation health education programs, fortification foods could be a viable sustainable option. We report results from community based double-masked, randomized trial 1–4 years evaluating effects micronutrients (especially zinc iron) delivered through fortified milk on growth, iron status markers as part four group study...
Verbal autopsy (VA) is recognized as the only feasible alternative to comprehensive medical certification of deaths in settings with no or unreliable vital registration systems. However, a barrier its use by national systems has been amount time and cost needed for data collection. Therefore, short VA instrument (VAI) needed. In this paper we describe shortened version VAI developed Population Health Metrics Research Consortium (PHMRC) Gold Standard Autopsy Validation Study using systematic...
Biofortification of staple food crops with zinc (Zn) can be one the cost-effective and sustainable strategies to combat deficiency prevent morbidity among target population. Agronomic approaches such as application Zn fertilizers soil and/or foliar spray seem a practical tool for biofortification wheat. However, there is need evaluate its efficacy from randomized controlled trials. This study aimed biofortified wheat flour on status impact children aged 4–6 years non-pregnant non lactating...
To estimate neonatal mortality, particularly within 24 hours of birth, in six low- and lower-middle-income countries.We analysed epidemiological data on a total 149 570 live births collected between 2007 2013 prospective randomized trials cohort study from predominantly rural areas Bangladesh, Ghana, India, Pakistan, the United Republic Tanzania Zambia. The mortality rate birth were estimated for all countries 6 was four with available data. findings compared published model-based estimates...
A blood protein signature discriminates active tuberculosis (TB) from other TB-like disease in adults regardless of HIV status.
The World Health Organization recommends 20 mg of zinc per day for 10 to 14 days children with acute diarrhea; in previous trials, this dosage decreased diarrhea but increased vomiting.
To evaluate the effect of Bifidobacterium lactis HN019 and prebiotic-fortified milk on iron status, anemia, growth among 1- to 4-year-old children.In a community-based double-masked, controlled trial in periurban population, 624 children were enrolled randomly allocated receive either fortified with additional probiotic prebiotic (n = 312) or control for 1 year. Probiotic contained an 1.9 x 10 colony-forming units per day B 2.4 g/day oligosaccharides milk. Hematological parameters estimated...
Abstract Background Bacterial pathogens cause substantial diarrhea morbidity and mortality among children living in endemic settings, yet antimicrobial treatment is only recommended for dysentery or suspected cholera. Methods AntiBiotics Children with severe Diarrhea was a 7-country, placebo-controlled, double-blind efficacy trial of azithromycin 2–23 months age watery accompanied by dehydration malnutrition. We tested fecal samples enteric utilizing quantitative polymerase chain reaction to...
Supplemental zinc during acute diarrhea reduces illness duration but also increases vomiting. In a recent trial, we found that children receiving lower daily doses of (5 mg or 10 vs. 20 mg) had rates vomiting with comparable stool output and diarrhea. We performed secondary analysis to identify sociodemographic clinical factors associated in data 4500 aged 6-59 months an episode (<72 h before enrollment) randomized, double-blind controlled trial India Tanzania. To clinically important risk...
The differential levels of sensory blockade pinprick, cold, and touch were monitored throughout the course spinal anesthesia administered to 50 patients determine variations in degree spread during onset, plateau, regression, establish effects epinephrine effect posture injection. A significant difference was observed between dermatomal level loss either pinprick or cold at 5 min given tetracaine with epinephrine, time maximum sitting position, all groups regression. Loss began later, never...
Interventions providing foods fortified with multiple micronutrients can be a cost-effective and sustainable strategy to improve micronutrient status physical growth of school children. We evaluated the effect micronutrient-fortified yoghurt on biochemical important (iron, zinc, iodine, vitamin A) as well indicators among children in Bogra district Bangladesh. In double-masked randomized controlled trial (RCT) conducted 4 primary schools, 1010 from classes 1–4 (age 6–9 years) were randomly...
BackgroundIn low-income countries, including the east African region, a third of neonatal deaths are due to infections. A substantial proportion these have been attributed sepsis, which can result from umbilical cord Evidence Asia suggests that chlorhexidine application reduces mortality, but no data Africa available. We aimed assess effect cleansing with 4% solution on mortality and omphalitis in rural settings sub-Saharan Africa.MethodsWe did community-based randomised controlled trial...
World Health Organization (WHO) guidelines do not recommend routine antibiotic use for children with acute watery diarrhea. However, recent studies suggest that a significant proportion of such episodes have bacterial cause and are associated mortality growth impairment, especially among at high risk diarrhea-associated mortality. Expanding dehydrated or undernourished may reduce improve growth.To determine whether the addition azithromycin to standard case management nonbloody diarrhea aged...
Background Maternal morbidity occurs several times more frequently than mortality, yet data on burden and its effect maternal, foetal, newborn outcomes are limited in low- middle-income countries. We aimed to generate prospective, reliable population-based the of major direct maternal morbidities antenatal, intrapartum, postnatal periods association with neonatal death South Asia sub-Saharan Africa. Methods findings This is a prospective cohort study, conducted 9 research sites 8 countries...
<b>Objective</b> To evaluate the efficacy of milk fortified with specific multiple micronutrients on morbidity in children compared same without fortification. <b>Design</b> Community based, double masked, individually randomised trial. <b>Setting</b> Peri-urban settlement north India. <b>Participants</b> Children (n=633) aged 1-3 randomly allocated to receive (n=316) or control (n=317). <b>Intervention</b> One year providing additional 7.8 mg zinc, 9.6 iron, 4.2 µg selenium, 0.27 copper,...