A5014302024- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Near-Field Optical Microscopy
- Neuroscience and Neural Engineering
- Force Microscopy Techniques and Applications
- Metamaterials and Metasurfaces Applications
- Cold Atom Physics and Bose-Einstein Condensates
- Photonic and Optical Devices
- Advanced biosensing and bioanalysis techniques
- Photoreceptor and optogenetics research
- Laser Material Processing Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Junctions and Nanostructures
- Advanced Surface Polishing Techniques
- Diamond and Carbon-based Materials Research
- Nanofabrication and Lithography Techniques
- Nanowire Synthesis and Applications
- CRISPR and Genetic Engineering
- Atomic and Molecular Physics
- Orbital Angular Momentum in Optics
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Integrated Circuits and Semiconductor Failure Analysis
- Luminescence and Fluorescent Materials
- Ion-surface interactions and analysis
Italian Institute of Technology
2016-2025
University of Salento
2023
University of Oulu
2023
Istituto di Nanotecnologia
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2018
University of Pisa
2006-2017
National Interuniversity Consortium for the Physical Sciences of Matter
2006-2017
Ariel University
2016
National Institute of Optics
2013-2016
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2006-2014
Three-dimensional vertical micro- and nanostructures can enhance the signal quality of multielectrode arrays promise to become prime methodology for investigation large networks electrogenic cells. So far, access intracellular environment has been obtained via spontaneous poration, electroporation, or by surface functionalization micro/nanostructures; however, these methods still suffer from some limitations due their intrinsic characteristics that limit widespread use. Here, we demonstrate...
A Universal plasmonic/microfluidic platform for spatial and temporal controlled intracellular delivery is described. The system can inject/transfect the desired amount of molecules with an efficacy close to 100%. Moreover, it highly scalable from single cells large ensembles without administering extracellular bath. latter enables quantitative control over injected molecules. We present in vitro delivering a broad range into compartment cell selective high parallelization potential. achieved...
Integration of plasmonic nanostructures with fiber-optics-based neural probes enables label-free detection molecular fingerprints via surface-enhanced Raman spectroscopy (SERS), and it represents a fascinating technological horizon to investigate brain function. However, developing neuroplasmonic that can interface deep regions minimal invasiveness while providing the sensitivity detect biomolecular signatures in physiological environment is challenging, particular because same waveguide...
In vitro neurotoxicology aims to assess and predict the side effects of exogenous chemicals toward human brain. Among exploited approaches, electrophysiological techniques stand out for high spatiotemporal resolution sensitivity, with patch clamp considered gold standard technique such purposes. However, structural toxicity metabolic may elude detection when only electrical activity is measured, highlighting need integrating recordings complementary approaches as optical methods. this study,...
The properties of polymeric nanofibers can be tailored and enhanced by properly managing the structure molecules at nanoscale. Although electrospun polymer fibers are increasingly exploited in many technological applications, their internal nanostructure, determining improved physical properties, is still poorly investigated understood. Here, we unravel functional made prototype conjugated polymers. unique features near field optical measurements to investigate nanoscale spatial variation...
Abstract Light focusing through a microbead leads to the formation of photonic nanojet functional for enhancing spatial resolution traditional optical systems. Despite numerous works that prove this phenomenon, method appropriately translate on top region interest is still missing. Here, by using advanced 3D fabrication techniques we integrated an AFM cantilever thus realizing system efficiently position nanojets. This approach robust and can be exploited in myriad applications, ranging from...
Delivery of molecules into intracellular compartments is one the fundamental requirements in molecular biology. However, possibility delivering a precise number nano-objects with single-particle resolution still an open challenge. Here we present electrophoretic platform based on 3D hollow nanoelectrodes to enable delivery single nanoparticles selected cells and monitoring by surface-enhanced Raman scattering (SERS). The gold-coated nanoelectrode capable confinement enhancement...
Abstract We present a theoretical and experimental study of plasmonic nanoelectrode architecture that is able to inject bunches hot electrons into an aqueous environment. In this approach, are accelerated in water by ponderomotive forces up energies capable exciting or ionizing molecules. This ability enabled the structure (extruding out metal baseplate), which allows for production intense spot at apex while maintaining electrical connection virtually unlimited charge reservoir. The...
Electroporation of in-vitro cultured cells is widely used in biological and medical areas to deliver molecules interest inside cells. Since very high electric fields are required electroporate the plasma membrane, depending on geometry electrodes voltages can be often critical cell viability. Furthermore, traditional electroporation configuration based planar there no a priori certain feedback about which has been targeted delivered addition fluorophores may needed gain this information. In...
In the present work, preparation of different styrene‐based polymer films containing small amounts TPE and evaluation their photoluminescent behaviour is reported. When dispersed in a poor solvent or glassy PS matrix, arrested intramolecular rotations its aryls favour strong emission light centred at about 455–460 nm. Conversely, fluorescence significantly weakens to faint signal when good solvents viscous but not matrices are used. Near‐field optical microscopy correlates with matrix...
Since its discovery, surface-enhanced Raman spectroscopy (SERS) has pushed researchers' interest to develop different kinds of active substrates for high sensitivity molecular detection. Defocused ion beam sputtering (IBS) represents a viable route the production large scale, highly reproducible SERS-active consisting near-field coupled nanowires featuring localized surface plasmon resonances in visible and near-infrared. Here we investigate field enhancement spatial confinement...
We demonstrate the generation of far-field propagating optical beams with a desired orbital angular momentum by using smooth optical-mode transformation between plasmonic vortex and free-space Laguerre-Gaussian modes. This is obtained means an adiabatically tapered gold tip surrounded spiral slit. The proposed physical model, backed up numerical study, brings about optimized structure that fabricated highly reproducible secondary electron lithography technique. Optical measurements...
Deterministic fractal antennas are employed to realize multimodal plasmonic devices. Such structures show strongly enhanced localized electromagnetic fields typically in the infrared range with a hierarchical spatial distribution. Realization of engineered operating optical regime would enable nanoplasmonic platforms for applications, such as energy harvesting, light sensing, and bio/chemical detection. Here, we introduce novel multiband metamaterial based on Sierpinski carpet (SC)...
Optical beams carrying orbital angular momentum (OAM) can find tremendous applications in several fields. In order to apply these particular photonic integrated devices innovative optical elements have been proposed. Here we are interested the generation of OAM-carrying at nanoscale level. We design and experimentally demonstrate a plasmonic vortex emitter, based on metal-insulator-metal holey lens. Our element is shown convert impinging circularly polarized light an state capable...
The use of nano/microspheres or beads for optical nanolithography is a consolidated technique achieving subwavelength structures using cost-effective approach; this method exploits the capability to focus electromagnetic waves into beams called photonic nanojets, which are used expose photoresist on placed. However, has only been produce regular patterns based spatial arrangement substrate, thus considerably limiting pool applications. Here, we present novel microsphere-based lithography...
A platform that enables simultaneous targeted drug delivery to single/few cells and intracellular recording at a network level from large cell populations.
Abstract Tuning optical properties of plasmonic nanostructures, including their absorption, scattering, and local‐field distribution is great interest for various applications that rely on energy regulated by effects. Conventional nanostructures enhance light scattering absorption simultaneously, leading to compromise either surface‐enhanced spectroscopy or thermoplasmonic applications. In this paper, a dual functional platform based hyperbolic meta particles (HMP) substrate exhibits...
Heart disease remains a leading cause of global mortality, underscoring the need for advanced technologies to study cardiovascular diseases and develop effective treatments. We introduce an innovative interferometric biosensor high-sensitivity label-free recording human induced pluripotent stem cell (hiPSC) cardiomyocyte contraction in vitro. Using optical cavity, our device captures interference patterns caused by contraction-induced displacement thin flexible membrane. First, we...
Abstract Presently, the in vitro recording of intracellular neuronal signals on microelectrode arrays (MEAs) requires complex 3D nanostructures or invasive and approaches such as electroporation. Here, it is shown that laser poration enables coupling planar electrodes without damaging neurons altering their spontaneous electrophysiological activity, allowing process to be repeated multiple times same cells. This capability distinguishes laser‐based neuron from more methods like...