RNA localization is one mechanism neurons use to spatially and temporally regulate gene expression at synapses. Here, we test the hypothesis that cells exhibiting distinct forms of synaptic plasticity will have differences in dendritically localized RNAs. Indeed, discover each major subregion adult mouse hippocampus expresses a unique complement dendritic Specifically, describe more than 1,000 differentially expressed RNAs, suggesting local translation are regulated cell type-specific...

The growth in obesity and rates of abdominal developing countries is due to the dietary transition, meaning a shift from traditional, fiber-rich diets Westernized high processed foods, sugars, unhealthy fats. Environmental changes, such as improving quality fat consumed, may be useful preventing or mitigating phenotype individuals with genetic predisposition, although this has not yet been confirmed. Therefore, study, we investigated how indices metabolically healthy (MHO) (MUO) based on...

Background & Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood. The exact etiology this disease unknown, but it believed to be related disorder catecholaminergic and serotonergic systems. Also, serum vitamin D levels patients with ADHD lower. Several studies have also shown effect on synthesis pathways dopamine, serotonin, a number neurotrophic factors. Therefore, study aimed investigate D3 supplementation...

Abstract Background The decline in sleep quality is one of the main public health problems affecting global population. Some studies have shown that a high-fat diet may be linked to changes circadian rhythm and quality. cholesterol/saturated fatty acid index (CSI) determines amount cholesterol saturated (SFA) people's dietary patterns can affect rhythm. However, date, no investigated effect this on these two variables. Therefore, our aim was investigate relationship between CSI obese...

Dietary patterns that promote mild metabolic acidosis may have a negative effect on bone and muscle, high dietary acid load (DAL) be detrimental to skeletal muscle mass mineral content. However, the association between content with has not been consistently reported in previous studies. The objective of study was evaluate potential renal net (PRAL) endogenous production (NEAP) pre-menopause women overweight or obesity Iran.Three hundred ninety body index (BMI) 25 were included this...

Abstract Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the other CA subregions. Notably, this includes a lack of typical long‐term potentiation stratum radiatum synapses. neurons express high levels several known and potential regulators metabotropic glutamate receptor (mGluR)‐dependent signaling including Striatal‐Enriched Tyrosine Phosphatase (STEP) Regulator G‐protein Signaling (RGS) proteins, yet functions these proteins regulating...

Abstract We aimed to investigate the interaction between transcript levels of taurine-upregulated gene 1 (TUG1) and metastasis-associated lung adenocarcinoma (MALAT1) Cholesterol-Saturated Fat Index (CSI) in relation visceral adiposity index (VAI) body (BAI). This cross-sectional study involved 346 women classified as obese overweight, aged 18 48 years. Dietary intake quality dietary fat were assessed using a validated reliable 147-item semi-quantitative food frequency questionnaire, with...

Abstract Background & aims For more than eight decades, cardiovascular disease (CVD) has remained the leading cause of death in world. CVD risk factors are multifaceted, with genetics and lifestyle both playing a role. The aim this study was to investigate association between genetic profile score for obesity GRS cardio-metabolic overweight obese women. Methods current cross-sectional conducted on 391 created by combining three single nucleotide polymorphisms [MC4R (rs17782313), CAV-1...

Abstract Background and aim Metabolic syndrome is one of the major public-health challenges, affecting one-quarter world population. Fatty acid quality indices are novel determinants this disease their interactions with genetic factors may have an impact on metabolic risk. Therefore, we aimed to investigate interaction between risk score (GRS) fatty (MetS) among overweight obese women. Methods In present cross-sectional study, 279 women (18–48 years old) were included. Several anthropometric...

Background and Objective. Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders in children. Increased oxidative stress decreased vitamin D may be associated with neurodevelopmental psychiatric disorders, such as ADHD. The purpose this study was to investigate effect supplementation on children attention disorder. Method. In double-blind, randomized, placebo-controlled trial, 75 (aged 6–12) diagnosed ADHD were randomly assigned into two groups....

Abstract Explosive shockwaves, and other types of blast exposures, are linked to injuries commonly associated with military service an increased risk for the onset dementia. Neurological complications following a injury, including depression, anxiety, memory problems, often persist even when brain damage is undetectable. Here, hippocampal explants were exposed explosive 1,3,5‐trinitro‐1,3,5‐triazinane (RDX) identify indicators blast‐induced changes within important neuronal circuitries....

The aim of the present study was to investigate association between dietary patterns, derived through latent class analysis (LCA), with visceral adiposity index (VAI), Triglyceride-Glucose Index (TyG), inflammation biomarkers, and body composition in overweight obese Iranian women. For this cross-sectional study, exposure assessed using a validated 147-item semi-quantitative food frequency questionnaire (FFQ). Dietary patterns were LCA. Binary logistic performed test associations VAI, TyG,...

Mental disorders are associated with dietary fatty acids and genome-wide association studies have found multiple risk loci robustly related to depression, anxiety, stress. The aim of this study is investigate the interaction genetic score (GRS) fat quality indices on mental health.This cross-sectional included 279 overweight obese women for N6/N3 ratio 378 CSI aged 18-68 years. Using reliable verified standard protocols, body composition, anthropometric indices, blood pressure, physical...

The nutrition transition in developing countries like Iran causes the increasing rise of obesity and abdominal rates. However, it is not yet well proven that environmental modifications improving quality beverage intake can be effective people who have a genetic predisposition to obesity. So, present study, we examine interaction between healthy index (HBI) with obesity-related metabolic risk factors overweight obese women.Based on inclusion exclusion criteria, 202 or females were chosen for...

<title>Abstract</title> Background: The association between plant-based foods with obesity, cardiovascular diseases (CVD), and their novel predictive biomarkers considering genetic predisposition remains uncertain. Given that diet is a significant modifiable risk factor, we sought to investigate the interactions susceptibility atherogenic factors, visceral body adiposity indices in Iranian women. Methods: This cross-sectional study was conducted on 377 obese overweight women, aged 18–48 from...

Mental health is affected by tryptophane (TRP) metabolism regulation. Diet-influenced gut microbiome regulates TRP metabolism. Thus, the present study aimed to explore relationship between type of dietary protein intake, microbiota, metabolites homeostasis, and mental well-being in healthy women. 91 females aged 18-50 were recruited based on protocol. Validate reliable questionnaires assessed intake health. Biochemical tests microbiota composition analyzed following manufacturer's...

Abstract Background: The growth in obesity and rates of abdominal developing countries is due to the dietary transition. Environmental changes, such as increasing quality fat consumed, may be useful prevent or improvement unhealthy phenotype persons who are genetically predisposed it, although this not yet firmly established. Therefore, current study, we look at how indices with metabolically healthy (MHO) (MUO) based on Karelis criteria interact genetic predisposition Iranian female adults....

Abstract Background Indirect immunofluorescence (IIF) on rat bladder epithelium (RBE) has been widely used to detect anti‐plakin antibodies present in paraneoplastic pemphigus (PNP). However, have also found a group of patients with vulgaris (PV). Objectives To assess the reactivity rate PV sera IIF using RBE as substrate and diagnostic usefulness aforementioned test. Methods Patients diagnosed presenting Razi Hospital, Tehran, Iran, were recruited. The patients' demographics, disease...

Background and Objective. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent psychiatric developmental disorders in children. Low serum vitamin D concentration elevated inflammation biomarkers might be involved neuropsychiatric disorders, such as ADHD. The purpose this study was to evaluate effect supplementation on TNF-α IL-6 levels children with attention disorder. Method. This randomized double-blind, placebo-controlled trial conducted 75 school-aged a diagnosis...

Introduction Proper nutrition can play an important role in preventing and improving disease progression patients with COVID-19. The Healthy Eating Index-2015 (HEI-2015) is one of the most common measures used to assess overall nutritional quality. This research aimed identify relationship between HEI-2015 score severity hospitalised military Methods cross-sectional study was conducted 295 (retired reserve) A validated food frequency questionnaire intake. To evaluate quality diet,...