A5086787338- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Effects and risks of endocrine disrupting chemicals
- HIV-related health complications and treatments
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Parvovirus B19 Infection Studies
- Pregnancy and preeclampsia studies
- HIV/AIDS drug development and treatment
- Air Quality and Health Impacts
- Pesticide Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Toxoplasma gondii Research Studies
- Advanced biosensing and bioanalysis techniques
- Energy and Environment Impacts
- Folate and B Vitamins Research
- Air Quality Monitoring and Forecasting
- Carcinogens and Genotoxicity Assessment
- Cardiovascular Health and Risk Factors
- Climate Change and Health Impacts
- HIV/AIDS Research and Interventions
Duke University
2023-2025
National Institute of Environmental Health Sciences
2020-2022
University of North Carolina at Chapel Hill
2016-2020
Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants protection to inform design a maternal vaccine remain elusive. Here, we characterized outcome primary rhesus CMV (RhCMV) infection during pregnancy in an competent nonhuman primate (NHP) model. RhCMV DNA was detected amniotic fluid and/or fetal tissues six 12 (50% placental transmission) CMV-naive macaque dams inoculated intravenously with early second trimester gestation....
Abstract Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role infection and pathogenesis is unknown. To examine vivo function an animal model evolutionarily closely related to humans, we identified characterized Rh05, Rh152/151 Rh173 as the complete set of vFcγRs encoded by rhesus CMV (RhCMV). Each one these proteins displays functional similarities prospective HCMV orthologs with respect...
Background Previously we observed elevated odds ratios (ORs) for total pesticide exposure and 10 birth defects: three congenital heart defects structural affecting the gastrointestinal, genitourinary musculoskeletal systems. This analysis examines association of those with to seven commonly applied active ingredients. Methods Cases were live‐born singleton infants from North Carolina Birth Defects Monitoring Program linked records 2003–2005; noncases served as controls (total n = 304,906)....
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV during pregnancy leads to a higher frequency (cCMV) than maternal re-infection, suggesting that immunity confers partial protection. However, poorly understood immune correlates protection against placental transmission contributes current lack an approved vaccine prevent cCMV. In this study, we characterized kinetics plasma rhesus (RhCMV) viral load (VL) RhCMV-specific antibody...
Abstract Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro , but their role infection and pathogenesis is unknown. To examine the vivo function of vFcγRs animal hosts closely related to humans, we identified characterized encoded by rhesus CMV (RhCMV). We demonstrate Rh05, Rh152/151 Rh173 represent complete set RhCMV vFcγRs, each displaying functional similarities respective HCMV orthologs with respect...
The altered immune states of aging and HIV infection may affect intracellular metabolism tenofovir disoproxil fumarate (TDF) emtricitabine (FTC); increased cellular senescence decreases FTC-triphosphate (FTCtp) concentrations. effects age inflammation on the ratio metabolites (IMs; diphosphate [TFVdp] FTCtp) to their endogenous nucleotides (ENs; dATP dCTP), a potential treatment efficacy marker, were assessed among participants Women's Interagency Study (WIHS), who ranged from 25 75 years....
<h3>Funding</h3> This study was supported by the Rheumatology Research Foundation Investigator Award (PI: Ardalan). <h3>Disclosures</h3> KA – Cure JM (support for clinical trial design with ReveraGen BioPharma) LES Bristol Myers Squibb (research grant), Sanofi (DSMB), UCB (DSMB) EYW Pharming Healthcare, Inc (advisory board, speaker bureau); Enzyvant Therapeutics <h3>Background/Purpose</h3> Juvenile lupus (JSLE) and dermatomyositis (JDM) are independent predictors of cardiovascular disease...
Cytomegalovirus (CMV) is the most common congenital infection and cause of birth defects worldwide. Primary CMV during pregnancy leads to a higher frequency (cCMV) than maternal re-infection, suggesting that immunity confers partial protection. However, poorly understood immune correlates protection against placental transmission contributes current lack an approved vaccine prevent cCMV. In this study, we characterized kinetics plasma rhesus (RhCMV) viral load (VL) RhCMV-specific antibody...
Background: Oxidative stress, the imbalance between reactive oxygen species and antioxidants, has been associated with sperm dysfunction in men. Phthalate exposure increased oxidative stress; however, few studies have explored joint association to multiple phthalate metabolites simultaneously circulating stress measures. Methods: We addressed this question among men (n=235) Environment Reproductive Health (EARTH) study, which couples seeking infertility treatment were recruited from a clinic...