A5012002137- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Electroconvulsive Therapy Studies
- Reproductive Biology and Fertility
- Cardiac Ischemia and Reperfusion
- Muscle and Compartmental Disorders
- Congenital gastrointestinal and neural anomalies
- Adenosine and Purinergic Signaling
- Congenital Anomalies and Fetal Surgery
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Sedative Agents
- Dye analysis and toxicity
- Neurogenetic and Muscular Disorders Research
- Bone health and treatments
- Treatment of Major Depression
- Healthcare Systems and Practices
- RNA regulation and disease
- Restraint-Related Deaths
- Genetic Neurodegenerative Diseases
- Thermal Regulation in Medicine
- Physical Education and Gymnastics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Connective tissue disorders research
- Health Literacy and Information Accessibility
Universidade Federal de São Paulo
2013-2025
Valencian Infertility Institute
2021
Universidade Estadual do Centro-Oeste
2016
University of Bío-Bío
2015
Universidade Federal da Grande Dourados
2010
Faculdade de Medicina do ABC
2007
Anhembi Morumbi University
2007
Universidade Federal Fluminense
2005
Simulation-based training is particularly beneficial for rare and life-threatening diseases such as Malignant Hyperthermia (MH). In addition, cognitive aids, including flowcharts checklists, can be used guidance in crisis, reducing demand simplifying patient care. We assessed the technical non-technical performance of anesthesiology residents when diagnosing treating a hypothetical case MH three different scenarios. This was an observational, cross-sectional, controlled study. Pairs...
Summary The morphological characteristics of the oviduct 12 sexually mature rheas ( Rhea americana ) were studied. Only left is developed as a long tube with length 122 ± 23.1 cm, and subdivided into infundibulum (15.2 4.0 cm), magnum (63.3 9.4 isthmus (5.6 3.1 uterus (16.0 4.2 cm) vagina (11.5 1.4 cm). mucous membrane oviduct, whole, possesses luminal folds covered by ciliated columnar epithelium secretory cells. part presents cranial opening thin fimbriae few tubular glands in caudal...
Malignant hyperthermia is an autosomal dominant hypermetabolic pharmacogenetic syndrome, with a mortality rate of 10%-20%, which triggered by the use halogenated inhaled anesthetics or muscle relaxant 10%-20% succinylcholine. The gold standard for suspected susceptibility to malignant in vitro contracture test response halothane and caffeine. determination families allows planning safe anesthesia without triggering agents patients known positive test. Moreover, patient whose suspicion was...
Malignant hyperthermia is an autosomal dominant hypermetabolic pharmacogenetic syndrome, with a mortality rate of 10%–20%, which triggered by the use halogenated inhaled anesthetics or muscle relaxant succinylcholine. The gold standard for suspected susceptibility to malignant in vitro contracture test response halothane and caffeine. determination families allows planning safe anesthesia without triggering agents patients known positive test. Moreover, patient whose suspicion was excluded...
Malignant Hyperthermia (MH) is an inherited hypermetabolic syndrome triggered by exposure to halogenated anesthetics/succinylcholine. The lack of knowledge regarding this condition might be associated with the rare occurrence MH reaction and symptoms. This observational study evaluated 68 patients from 48 families confirmed or suspected susceptibility due medical history idiopathic increase creatine kinase MH-related myopathies. Participants were assessed a standardized questionnaire...
Malignant Hyperthermia (MH) is a pharmacogenetic disorder triggered by halogenated anesthesia agents/succinylcholine and characterized hypermetabolism crisis during anesthesia, but also day-to-day symptoms, such as exercise intolerance, that may alert the health professional.The study aimed to analyze incidence of fatigue in MH susceptible patients variables can impact perception fatigue, level routine physical activity depression.A cross-sectional observational was carried out with three...
Congenital malformations correspond to one of the main causes embryonic loss during gestational process. They result from interaction several factors such as multifactor heredity, chromosomal and genetic alterations environmental agents; however, unknown aetiology also can be present. In this article, we have used 10 embryos, a frigorific area Dracena, SP, Brazil, which were fixed in Bouin solution for macro- micro-scopic description. We could verify presence an encephalic tissue mass on...
Rhabdomyosarcomas have been described in association with thyroid disease, dermatomyositis, Duchenne muscular dystrophy, and dystrophy models but not patients ryanodine receptor-1 gene (RYR1) pathogenic variants. We here an 18-year-old male who reported a cervical nodule. Magnetic resonance images revealed mass the ethmoidal sinus corresponding to rhabdomyosarcoma. As his father died from malignant hyperthermia (MH), vitro contracture test was conducted positive for MH susceptibility. Muscle...
Malignant Hyperthermia (MH) is a pharmacogenetic, hereditary and autosomal dominant syndrome triggered by halogenates/succinylcholine. The In Vitro Contracture Test (IVCT) the gold standard diagnostic test for MH, it evaluates abnormal skeletal muscle reactions of susceptible individuals (earlier/greater contracture) when exposed to caffeine/halothane. MH susceptibility episodes IVCT seem be related individual features. To assess variables that correlate with in Brazilian patients referred...
Abstract Background Malignant hyperthermia (MH) is a rare, hereditary disease with hypermetabolic response to volatile anesthetics/succinylcholine. Susceptible patients face difficulties due lack of knowledge about MH. As informational materials could increase and adherence prevention/therapy, digital information rare diseases validated for needed. Our objective was evaluate the following: (1) impact manuals on knowledge/quality life MH (2) access services. Materials methods Fifty...
Abstract Study question Is hyperspectral imaging of individual sperm cells an appropriate candidate technique with potential to identify molecular characteristics single spermatozoa prior microinjection? Summary answer Preliminary tests have allowed us obtain the images, set up methodology and correct segmentation each into its signature spectra. What is known already Although image techniques such as fluorescence microscopy Raman spectroscopy been used biomarkers on cells, their translation...
Background Statins are currently the preferred agent for treatment of hypercholesterolemia. However, myalgia, increased serum levels creatinekinase (CK) and even rhabdomyolysis may occur, characterizing cholesterol lowering agents myopathy (CLAM), with a multifactorial aetiology. In statin monotherapy, incidence CLAM is 0.1 to 0.5 % dose related. RYR1 (ryanodine 1) gene alteration was observed in patients CLAM, an animal model MH (malignant hyperthermia) showed hyper metabolism after...