A5012761391- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Tuberous Sclerosis Complex Research
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Kidney Disease and Diabetes
- Sperm and Testicular Function
- Erythrocyte Function and Pathophysiology
- S100 Proteins and Annexins
- MRI in cancer diagnosis
- Cancer-related gene regulation
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Histone Deacetylase Inhibitors Research
- Biomarkers in Disease Mechanisms
- Bladder and Urothelial Cancer Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
First Affiliated Hospital of Soochow University
2011-2023
Soochow University
2011-2023
Huzhou Central Hospital
2021
Shenyang Medical College
2018-2020
MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs approximately 22 nucleotides in length that play role wide range biological processes. Abnormal miRNA function has been implicated various human cancers including prostate cancer (PCa). Altered expression may serve as biomarker for diagnosis and treatment. However, limited data available on the cancer-specific miRNAs. Integrative computational bioinformatics approaches effective detection potential outlier miRNAs cancer. The...
This study is aimed at constructing a nomogram to predict the risk of clinically significant prostate cancer (csPCa) based on aggregate index systemic inflammation (AISI) and imaging-reporting data system version (PIRADS) score.Clinical patients who had undergone initial biopsy from January 2019 December 2021 were collected. Patients randomized in 7 : 3 ratio training cohort validation cohort. Potential factors for csPCa identified by univariable multivariate logistic regression. Nomogram...
Background: Gliomas are one of the most lethal cancers in human central nervous system. Despite clinical treatment advancements, prognosis patients with glioma remains poor. KDM2B is a histone lysine demethylase, which has been observed multiple tumors. But concrete role gliomas to be further illustrated. Methods: The expression was detected immunohistochemistry and Western blot assay. Furthermore, knockdown U87 U251 cell lines, proliferation capacity evaluated by viability assay, colon...
S100A12 belongs to the S100 family and acts as a vital regulator in different types of tumors. However, function thyroid carcinoma has not yet been investigated. In this study, we analyzed expression human papillary cancer (PTC) samples two PTC cell lines. addition, explored effects on progression vitro vivo. Our results showed that was significantly upregulated specimens. Moreover, silencing markedly inhibited proliferation, migration, invasion cycle progression. knockdown reduced CyclinD1,...
Carboxyl terminus of Hsc-70-interacting protein (CHIP) is an E3 ubiquitin ligase that induces the ubiquitination and degradation numerous tumor-associated proteins serves as a suppressor or promoter in tumor progression. To date, molecular mechanism CHIP prostate cancer remains unknown. Therefore, present study investigated biological function cells obtained evidence expression upregulated tissues. The vector was introduced into DU145 cell behaviour examined through series experiments,...
Lung squamous cell carcinoma (LUSC) is a subtype of non-small lung cancer with poor prognosis. This study aimed to explore the role KDM2B in development LUSC. The results this demonstrated that was upregulated LUSC tissues and lines. Knockdown reduced viability colony forming ability SK-MES-1 NCI-H520 cells. inhibition glucose consumption, lactate production, ATP level, also downregulated expression LDHA GLUT1. knockdown decreased protein LC3-I p62, increased LC3-II Beclin-1. Furthermore,...
Gastric cancer (GC), a highly prevalent gastric cancer, has high-risk mortality. Thus, investigating strategies to counteract its growth is important provide theoretical guidance for prevention and treatment. It been pointed out that abnormal expression of microRNAs (miRNAs) serves as noninvasive biomarkers GC. This present study probed into the role miR-622 NUAK family SNF1-like kinase 1 (NUAK1). Five mRNA datasets (GSE64916, GSE118916, GSE122401, GSE158662, GSE159721) one miRNA dataset...
Renal cell carcinoma (RCC) accounts for 85%&90% of all kidney tumors. Although the majority renal tumors in surgical series are malignant, a number patients do undergo nephrectomy benign lesions.1 Such minimal fat angiomyolipomas (AML) visually indistinguishable from RCC and present particular diagnostic difficulties.2,3 In this study, CT region whole mass (ROW) is advocated. METHODS Patients A retrospective study was conducted; we classified 117 into two groups, 96 were 21 AML by pathologic...
Objective To evaluate the value of intraoperative frozen section examination (IFS) in diagnosis and surgical procedures selection for renal occupying lesions. Methods From January 2006 to December 2010,IFS was used 114 men 81 women with lesions.The mean age 52 years (range 17 -78).In 104,89,and 2 patients,lesions were right,left bilateral kidneys,respectively.All patients underwent physical examination,129 asymptomatic at presentation while clinical symptoms observed 66.The largest dimension...