Atypical adenomatous hyperplasia (AAH) is classified as a precancerous lesion of lung adenocarcinoma. We established an immortalized AAH cell line (PL16T) and human non‐neoplastic bronchial epithelial (PL16B) from the same patient by transfection with gene for SV40 large T antigen. The expression profile PL16T was compared that PL16B suppression subtractive hybridization method. From 704 selectively hybridized clones, we finally selected 25 fragments mRNA showed transcription levels more...

The effects of FM system fitted into the normal hearing ear (NHE) or a cartilage conduction aid (CCHA) affected (AE) on speech recognition ability in noise were examined children with unilateral congenital aural atresia (UCAA). In bilateral (BNH), score (SRS) was significantly decreased noisy environment -5 dB signal-to-noise ratio (SNR), compared those quiet. UCAA, SRS environments 0 and SNR, UCAA decreased, BNH. aided by NHE better than unaided same group. CCHA AE tended to be higher can...

Abstract Congenital dacryocystocele is a relatively rare type of nasolacrimal duct obstruction that may induce respiratory distress during the early neonatal period. We encountered case bilateral congenital dacryocystoceles with intranasal cysts in premature infant delivered at 34 weeks gestation. The patient developed symptoms failure immediately after birth, but no ophthalmologic symptoms. Treatment nasal continuous positive airway pressure via mask, instead prong, effectively relieved...

Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder caused by heterozygous POLD1 mutations. To date, 13 patients affected mutation-caused MDPL have been described. We report clinically undiagnosed 11-year-old male who noted joint contractures at 6 years of age. Targeted exome sequencing identified known mutation [NM_002691.3:c.1812_1814del, p.(Ser605del)] that diagnosed him as the first Japanese/East Asian case.

Objectives : We examined speech recognition ability of elementary school-aged Japanese children with unilateral hearing loss under noisy environments and then the effects FM system fitted into their normal ear on ability.Methods Twelve severe-to -profound sensorineural ten age-matched bilateral received test in quiet environments.Other nine severe-to-profound or without receiver to environments.Results Signal-to-noise ratio (SNR) school classrooms was estimated be -6.9 dB at a preferential...

The adenomatoid odontogenic tumor (AOT) is a rare benign that mostly found in jawbone. It generally the incisor region of maxilla young females. rarely extends into paranasal sinuses. This article describes case AOT and occupying maxillary sinus nasal cavity.A 20-year-old woman was referred to our department because swelling left cheek. CT examination showed cystic lesion including calcified structures an impacted tooth. A biopsy specimen revealed tumor. We performed extirpation combined...

We report on a 79-year-old woman complaining of progressive dysphagia as an initial symptom tetanus. Endoscopic and videofluoroscopic examination her swallowing process showed dysphagea with food retention in the pyriform sinus, probably because spasm cricopharyngeal muscles due to The patient was cured tetanus antitoxin antibiotics without any sequelae. Tetanus must be considered differential diagnosis spite lack history injury.

Objective : In the present study, an attempt was made to evaluate acoustic characteristics of voice in pediatric patients with vocal nodules using analysis voice. Methods Thirty-five and 32 control children without dysphonia were enrolled this study. Their samples analyzed Multi-Dimensional Voice Program. Acoustic parameters voice, such as pitch period perturbation quotient (PPQ), amplitude (APQ), noise-to-harmonic ratio (NHR), measured. Results phonation at a loudness over 80 dBA, PPQ, APQ,...

小中学校の耳鼻咽喉科定期健康診断を受診した1384名について，嗄声の出現率とスポーツ活動との関連を検討した．嗄声の出現率は，女児（5.2％）に比べて男児（17.7％）が高く，男児は小学校3年生まで高く4年生以降に減少し，女児は小学校2年生まで高く以降減少したが中学校2，3年生では高かった．小学校の高学年ではスポーツ活動を行っていない児童（男児4.9％，女児0.6％）に比べて，スポーツ活動を行っている児童（男児21.2％，女児5.8％）は嗄声の出現率が有意に高かった．スポーツの種類と嗄声とのオッズ比は，男児の小学校低学年の野球が2.88，小学校高学年でサッカー2.29，野球2.92で高く，強い声門閉鎖を伴う屋外の団体スポーツであることが要因と考えられた．小学校の男児に野球やサッカーを行わせる場合には，声の衛生を行い嗄声の予防が必要である．中学生は，対象者を増やして再検討が必要である．

Pineal glial cysts associated with bilateral hearing impairment are very rare. Here, we present the case of a 13-year-old boy pineal cyst, which caused severe persisting from 6 years age. When patient was old, acuity about 40 dB on audiometry. Upon admission to our otolaryngology department, his audiogram revealed worsening (80 dB). Magnetic resonance imaging (MRI) an abnormal cyst tectal compression left hardly normal brainstem auditory evoked potentials (BAEPs). We obtained informed...

The adenomatoid odontogenic tumor (AOT) is a rare benign that mostly found in jawbone. It generally the incisor region of maxilla young females. rarely extends into paranasal sinuses. This article describes case AOT and occupying maxillary sinus nasal cavity.A 20-year-old woman was referred to our department because swelling left cheek. CT examination showed cystic lesion including calcified structures an impacted tooth. A biopsy specimen revealed tumor. We performed extirpation combined...

Metastatic hepatocellular carcinoma in the sinonasal region is rare. We report case of an 85-year-old man who presented to us with a history recurrent nasal bleeding. A reddish and hemorrhagic tumor was found right septum. Histopathological examination biopsy specimen revealed metastatic carcinoma. The patient had been diagnosed as having many years ago received multiple sessions transcatheter arterial chemoembolization. Computed tomography magnetic resonance imaging showed slightly...

Metastatic hepatocellular carcinoma in the sinonasal region is rare. We report case of an 85-year-old man who presented to us with a history recurrent nasal bleeding. A reddish and hemorrhagic tumor was found right septum. Histopathological examination biopsy specimen revealed metastatic carcinoma. The patient had been diagnosed as having many years ago received multiple sessions transcatheter arterial chemoembolization. Computed tomography magnetic resonance imaging showed slightly...

In order to clarify the role of arteriosclerosis in development and recovery from sudden deafness, we evaluated patients with using pulse wave velocity (PWV) as a marker. Arteriosclerosis was observed 69% deafness initial hearing level worse than those without arteriosclerosis. After treatment steroid lipid microsphere-incorporated prostaglandin E1 (lipo-PGE1), rate significantly lower These findings suggest that is an exacerbating condition poor prognostic factor deafness. On other hand,...

In order to clarify the role of arteriosclerosis in development and recovery from sudden deafness, we evaluated patients with using pulse wave velocity (PWV) as a marker. Arteriosclerosis was observed 69% deafness initial hearing level worse than those without arteriosclerosis. After treatment steroid lipid microsphere-incorporated prostaglandin E1 (lipo-PGE1), rate significantly lower These findings suggest that is an exacerbating condition poor prognostic factor deafness. On other hand,...

症例は67歳の男性, 右不全麻痺と構音障害を主訴に来院した. 入院時神経学的所見では, 顔面を含む右半身不全麻痺と, 顔面を除く右半身の痛覚過敏・しびれ・痛み・振動覚低下, 右上下肢の腱反射亢進と病的反射の出現を認めた. 入院翌日の頭部MRIでは症状を説明する病巣は認めず, 短潜時体性感覚誘発電位では右刺激にてP14以降の振幅の著しい低下, 脳血管造影では左椎骨動脈の閉塞を認めた. 発症18日目に再度行った頭部MRIでは左延髄内側に梗塞巣を認めた. 本症例は Dejerine 症候群の古典的三徴を示さず, 非典型的症状を伴い, さらに初回MRIで病巣が描出できなかった事により, 診断に難渋した症例であった.

We report two young patients of Wallenberg syndrome who presented with acute vertigo as the initial symptom. Neither Case 1, an 8-year-old girl, nor 2, a 29-year-old man, showed any abnormal findings on magnetic resonance imaging (MRI) day 1. In addition to nystagmus, several neurological signs became positive during clinical course. Finally, diagnosis was made in both cases based detection lateral medullary infarction follow-up MRI conducted 4. Stroke should be considered differential...

医学教育における VOXEL-MAN TempoSurg を用いたバーチャルリアリティー (VR) 側頭骨手術シミュレーション実習の有用性を明らかとする目的で, Bedside learning における医学生の側頭骨の解剖学的知識や側頭骨手術の手技に関する理解度を指標とした検討を2年間行った. 実習は, 1年目は同一医師, 2年目は複数の医師が指導した. 実習前後に側頭骨の解剖学的知識を問う筆記試験と手術手技の理解に関する自己評価を実施した. その結果, 実習1年目の筆記試験の正答率は平均51.8点から83.9点に, 2年目は平均49.4点から80.0点へ上昇した. 手術手技に関する自己評価では「よく理解できた」「ほぼ理解できた」と答えた医学生の割合は, 乳突削開術で1年目が84.3%, 2年目が76.4%, 鼓室開放で1年目が74.8%, 2年目が66.4%, 蝸牛開窓で1年目が67.8%, 2年目が52.3%であった. 複数の指導医による実習でも, 同一指導者の実習と比較して, 筆記試験の成績や蝸牛開窓以外の手術手技に関する理解度に差は認められなかった. VR...

The division of pediatric otology was established in the Department Otolaryngology Head and Neck Surgery Tokushima University Hospital 2000, continues to examine children with hearing loss living Prefecture. Pediatric otolaryngologists are engaged diagnosis follow-up loss, aid fitting, performance cochlear implant surgery patients loss. In particular, they also involved performing genetic analyses providing counseling, constituting multidisciplinary conferences for determining indications...

In Japan, infant health examinations and school medical checkups are well established useful for early identification of speech language disorders in children. Tokushima, we have well-developed advanced examination checkup systems, where doctors cooperation with speech-language-hearing therapists perform detailed screening children disorders. Our findings regard to development through out the systems suggest that prevalence delayed has recently increased preschool-age school-age We speculate...

The speech recognition ability in children with unilateral hearing loss is similar to that age-matched normal quiet and slightly noisy environments. However, environments, such as working classrooms, show reduced compared hearing. An FM system, consisting of a microphone worn by the teacher receiver fitted ear students impairment, used school classrooms. into was shown improve Use system recommended an audiological management tool overcome listening difficulties