A5009438868- BRCA gene mutations in cancer
- Health Education and Validation
- CRISPR and Genetic Engineering
- Medical Malpractice and Liability Issues
- Education and Public Policy
- Science and Education Research
- Phytochemistry Medicinal Plant Applications
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Environmental Toxicology and Ecotoxicology
- Spectroscopy and Chemometric Analyses
- Mesenchymal stem cell research
- Biological Stains and Phytochemicals
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Education during COVID-19 pandemic
- Acute Myeloid Leukemia Research
- Innovations in Medical Education
- Viral Infections and Immunology Research
- Metabolomics and Mass Spectrometry Studies
- Chromosomal and Genetic Variations
- Problem and Project Based Learning
- Ethnobotanical and Medicinal Plants Studies
- Health Sciences Research and Education
- Spectroscopy Techniques in Biomedical and Chemical Research
Universidade Federal de Alagoas
2008-2022
Rio de Janeiro Federal Institute of Education, Science and Technology
2008
Universidade Federal do Rio de Janeiro
2000-2004
Hospital Universitário Clementino Fraga Filho
2003-2004
Brazilian Agricultural Research Corporation
1998-2000
Plum Island Animal Disease Center
1997
Isolates of foot-and-mouth disease virus (FMDV) exist as complex mixtures variants. Two different serotype O1 Campos preparations that we examined contained two variants with distinct plaque morphologies on BHK cells: a small, clear-plaque replicates in and CHO cells, large, turbid-plaque only grows cells. cDNAs encoding the capsids these were inserted into genome-length FMDV type A12 infectious cDNA used to produce chimeric viruses exhibited phenotype original Analyses viruses, hybrids...
RESUMO As Instituições de saúde ensino superior têm buscado efetuar mudanças em seus projetos político-pedagógicos, replanejando, assim, currículos. Esta pesquisa teve por objetivo avaliar o processo ensino-aprendizagem no estágio supervisionado, quando realizado com a integração estudantes diversos cursos na área da saúde, utilizando como abordagem um estudo caso etnográfico, meio observação participante, questionário semiestruturado e grupo focal. Mediante triangulação dos dados, pôde-se...
Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation macrophages, which major effectors killing this organism. lymphocytes that proliferate in response B. were characterized for phenotype and cytokine activity. Human, murine, bovine exhibited type 1 profile, suggesting an analogous these different hosts. In vivo protection afforded by...
A series of coumarin derivatives and isosteres were synthesized from the reaction triflic intermediates with phenylboronic acids, terminal alkynes, organozinc compounds through palladium-catalyzed cross-coupling reactions. The in vitro cytotoxic effect was evaluated against two non-small cell lung carcinoma (NSCLC) lines (A-549 H2170) a normal line (NIH-3T3) using cisplatin as reference drug. Additionally, effects most promising derivative (9f) reversing epithelial-to-mesenchymal transition...
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that distributed widely in the tropical and subtropical regions of world. In northeast region Brazil, where B. called "sucupira-preta," stem bark used folk medicine to treatment inflammatory painful diseases. This study aimed evaluate antinociceptive activity aqueous extract dried virgilioides. The doses 50, 100, 200, 400 mg/kg was administered orally 1 hour prior pain induction. Only 200 produced an inhibition by 61% 74%,...
Germline inactivating variants in BRCA1 lead to a significantly increased risk of breast and ovarian cancers carriers. While the functional effect many can be inferred from DNA sequence, determining missense present significant challenge. A series biochemical cell biological assays have been successfully used explore impact these on function BRCA1, which contribute assessing their likelihood pathogenicity. It has determined that co-localize with structural or motifs are more likely disrupt...
In this work we have used Fourier transform infrared (FTIR) / vibrational absorption (VA) spectroscopy to study two cancer cell lines: the Henrietta Lacks (HeLa) human cervix carcinoma and 5637 bladder lines. Our goal is experimentally investigate biochemical changes differences in these cells lines utilizing FTIR spectroscopy. We chemometrical statistical method principal component analysis (PCA) spectral differences. been able identify certain bands spectra which are so-called biomarkers...
The herbicide trifluralin is one of the most widely herbicides used in weed control. This study aims to evaluate genotoxic potential on Colossoma macropomum (tambaqui) using a multi-biomarker approach. C. highly adapted and predominant species variety water bodies delta region São Francisco River other river systems Brazil. mutagenic effects different concentrations (0.25, 0.5, 0.75, 1.0 mg L-1) peripheral erythrocytes were investigated micronucleus (MN), comet assay apoptosis test. After an...
Our College of Medicine implemented a new curriculum in 2006 following the release 2001 National Curricula Guidelines from Ministry Education Brazil. These guidelines establish core comprehensive competences, such as those involved patient care, health care management, communication, decision-making and leadership skills, recommend use student-centred methods, integration content learning activities, well early clinical experiences increased community-based services. Although had been our...
Objetivo: Conhecer a preceptoria em odontologia sob o ponto de vista dos profissionais/cirurgiões dentistas quanto sua função e prática pedagógica. Métodos: Trata-se uma pesquisa com abordagem qualitativa na modalidade estudo caso, técnica da entrevista semiestruturada observação participante os 12 cirurgiões que atuavam como preceptores estágio no serviço público. Os dados foram interpretados luz análise conteúdo temática. Resultados: relataram reconhecem cenários pratica locais...
Ribosomal DNA (rDNA) is a multigenic family composed of one or more clusters repeating units (RU). Each unit consists highly conserved sequences codifying 18S, 5.8S and 28S rRNA genes intercalated with poorly regulatory between species. In this work, we analyzed the rDNA Drosophila arizonae, member mulleri complex (Repleta group). Using genomic restriction patterns, cloning mapping some representative fragments, were able to construct map. RU in species are 13.5-14 kb long, sites completely...
Este estudo propôs demonstrar o tutorial (mentoring) como metodologia de aprendizagem para a formação em Enfermagem. Realizou-se um Estudo Caso com abordagem metodológica quantitativa e qualitativa. Os sujeitos da pesquisa foram os estudantes do segundo quinto ano curso enfermagem. A construção dos dados se deu por meio questionário estruturado descrição uma situação-problema. quantitativos analisados pelo teste não paramétrico Kruskal Wallis construídos resposta à situação problema...
A monitoria da disciplina de Biologia Celular e Molecular do ano 2020, Instituto Ciências Biológicas Saúde (ICBS), se modificou para atender a nova realidade que surgiu com pandemia novo coronavírus (SARS COV 2). Para dar continuidade às atividades, Universidade Federal Alagoas (UFAL) implementou o Período Letivo Excepcional (PLE) aulas totalmente remotas. Dessa forma, professores, alunos monitores tiveram adaptar essa ensino, procurando encontrar as melhores plataformas programas adequados,...