A5067202760- Algal biology and biofuel production
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Electrostatics and Colloid Interactions
- Nanopore and Nanochannel Transport Studies
- Forest Insect Ecology and Management
- Plant Pathogens and Fungal Diseases
- Supramolecular Self-Assembly in Materials
- Fish Ecology and Management Studies
- Thyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Biological Control of Invasive Species
- Radiomics and Machine Learning in Medical Imaging
- Insect Pest Control Strategies
- Trace Elements in Health
- Luminescence and Fluorescent Materials
- Genomics and Chromatin Dynamics
- Growth Hormone and Insulin-like Growth Factors
- Artificial Intelligence in Healthcare
- Acupuncture Treatment Research Studies
- Yeasts and Rust Fungi Studies
- Transgenic Plants and Applications
- Mycorrhizal Fungi and Plant Interactions
- COVID-19 Impact on Reproduction
- Lipid Membrane Structure and Behavior
Costa Rican Department of Social Security
2023
Universidad de Costa Rica
2023
Fundación Renal
2021-2023
University of Bern
2022
Institut Laue-Langevin
2018-2021
Universidad de Burgos
2018-2021
Chalmers University of Technology
2021
National Agricultural Technology Institute
2004
National Research Council
2003
University of Cienfuegos
1996-1997
DNA is a flexible molecule, but the degree of its flexibility subject to debate. The commonly-accepted persistence length ${l}_{p}\ensuremath{\approx}500\phantom{\rule{0.16em}{0ex}}\AA{}$ inconsistent with recent studies on short-chain that show much greater do not probe origin. We have performed x-ray and neutron small-angle scattering short sequence containing strong nucleosome positioning element analyzed results using modified Kratky-Porod model determine possible conformations. Our...
During diffusion of nanoparticles bound to a cellular membrane by ligand–receptor pairs, the distance laterally mobile interface is sufficiently short for their motion depend not only on membrane-mediated diffusivity tethers but also in yet fully understood manner nanoparticle size and interfacial hydrodynamics. By quantifying diffusivity, velocity, individual membrane-bound liposomes subjected hydrodynamic shear flow, we have successfully separated contributions from particle number...
The supramolecular assembly of tetraphenylethylene (TPE)–DNA conjugates is presented. length the TPE sticky ends exerts a pronounced effect on formation aggregation-induced emission (AIE)-active vesicles.
The influence of molecular confinement on the melting transition oriented Na-DNA fibers submerged in poly(ethylene glycol) (PEG) solutions has been studied. PEG solution exerts an osmotic pressure which, turn, is related to DNA intermolecular distance. Calorimetry measurements show that temperature increases and width decreases with decreasing Neutron scattering was used monitor integrated intensity a Bragg peak from B-form as function temperature. data were quantitatively analyzed using...
The interaction between metallic and biological nanoparticles (NPs) is widely used in various biotechnology biomedical applications. However, detailed characterization of this type challenging due to a lack high-throughput techniques that can quantify both size composition suspended NP complexes. Here, we introduce technique called ``twilight nanoparticle tracking analysis'' (tNTA) demonstrate it provides quantitative relationship the measured optical signal dielectric-metal We assess...
Mccullough published in 1983 a series of 3 cases from the Mayo Clinic and nine rest world, proposing specific clinical entity Wilson´s disease (WD) with fatal outcome if not transplanted. Costa Rica has highest incidence world (5.2/100.000 inhabit); we found total population patients, 5.8% fulminant Wilson (FW) (7/120 patients), pediatric population, 14.7% (5/34 children). This study aimed to define FW as an by its clinical, biochemical, histological genetic characteristics diagnose earlier...
It's common to include alfa 1 antitrypsin deficiency (AATD) in the diagnostic workup of children with cirrhosis, unlike adults, where we seldom test for it. Some its characteristics are unusual and can miss them as it tends have a silent clinical course, showing advanced indirect signs due portal hypertension. This study aimed establishing biochemical, clinical, molecular, genetic that lead diagnosis cirrhosis ATTD. We analyzed 26 cases adults AATD related disease Costa Rica. establish...
The melting transition of Li-DNA fibers immersed in ethanol-water solutions has been studied using calorimetry and neutron diffraction techniques. data have analyzed the Peyrard-Bishop-Dauxois model to determine strengths intra- inter-base pair potentials. analysis show that potentials are weaker than those for DNA water. They become still less stable as ethanol concentration increases but, conversely, more compact distances between base pairs regular. results is relatively insensitive local...